IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production. e91 a57 macrophage CL:0000235 Cell Type 26253919 PubMed A network map of Interleukin-10 signaling pathway. J Cell Commun Signal 2016 Verma R Balakrishnan L Sharma K Khan AA Advani J Gowda H Tripathy SP Suar M Pandey A Gandotra S Prasad TS Shankar S signaling pathway PW:0000003 Pathway Ontology 23943603 PubMed The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Brief Funct Genomics 2013 Hutchins AP Diez D Miranda-Saavedra D Interleukin-10 signaling pathway PW:0000515 Pathway Ontology