IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production. e91a57Interleukin-10 signaling pathwayPW:0000515Pathway OntologymacrophageCL:0000235Cell Type23943603PubMedThe IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges.Brief Funct Genomics2013Hutchins APDiez DMiranda-Saavedra Dsignaling pathwayPW:0000003Pathway Ontology26253919PubMedA network map of Interleukin-10 signaling pathway.J Cell Commun Signal2016Verma RBalakrishnan LSharma KKhan AAAdvani JGowda HTripathy SPSuar MPandey AGandotra SPrasad TSShankar S