Inflammation is a protective response of cells to pathogens, infection or tissue damage. It involves the coordinated communication of different immune cells and blood vessels through an intricate cascade of molecular signals. Inflammation can cause fever, cardiovascular pathology, allergy anaphylaxis, fibrosis, autoimmunity, etc.
The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected. Each phase has many options that are triggered based on the type pathogen introduced.
In addition, chronic inflammatory conditions, where an inducer is not well defined, are becoming more common. These conditions are of particular interest because they coincide with other diseases such as obesity, type 2 diabetes, atherosclerosis, neurodegenerative diseases and cancer. [http://www.thermofisher.com/ls/en/home/life-science/cell-analysis/signaling-pathways/inflammatory-response-pathway.html#]
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP453 CPTAC Assay Portal]ecba7bB cellCL:0000236Cell Typeinflammatory response pathwayPW:0000024Pathway OntologyfibroblastCL:0000057Cell Type9378992PubMedAttenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor.J Immunol1997Monahan JSiegel NKeith RCaparon MChristine LCompton RCusik SHirsch JHuynh MDevine CPolazzi JRangwala STsai BPortanova J19028820PubMedPolymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.Clin Chem2009Greisenegger SZehetmayer SBauer PEndler GFerrari JLang WJanisiw MSteiner LCheng SLalouschek WMannhalter C