Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT). This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org. e3c AMPK AMPK AMPK AMPK AMPK AMPK AMPK Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Ga/1 Ga/1 Ga/1 Ga/1 Ga/1 Ga/1 PKA PKA PKA PKA PKA PKA PKA PKC PKC PKC PKC PKC PKC PKC PKC PKC PKC PLCB PLCB PLCB PLCB SMAD SMAD mTOR LATS1/2 MST1/2 LATS1/2 Nf2 MST1/2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 parentid=Q9NRM7; parentsymbol=LATS2; site=EHAFyEFtFRRFFDD; position=thr1041; sitegrpid=31843001; ptm=p; direction=u parentid=O95835; parentsymbol=LATS1; site=EHAFyEFtFRRFFDD; position=thr1079; sitegrpid=457595; ptm=p; direction=u parentid=P35240; parentsymbol=NF2; site=DTDMKRLsMEIEKEK; position=ser518; sitegrpid=448282; ptm=p; direction=u parentid=Q13043; parentsymbol=STK4; site=DtMAkRNtVIGTPFW; position=thr183; sitegrpid=447925; ptm=p; direction=u parentid=Q9GZV5; parentsymbol=WWTR1; site=AQHVRsHssPAsLQL; position=ser89; sitegrpid=457660; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=PQHVRAHssPAsLQL; position=ser127; sitegrpid=448847; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=sGLsMsSySVPRtPD; position=tyr407; sitegrpid=473004; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=ktANVPQtVPMRLRk; position=thr83; sitegrpid=27460703; ptm=p; direction=d parentid=Q9GZV5; parentsymbol=WWTR1; site=AQHVRsHssPAsLQL; position=ser89; sitegrpid=457660; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=PQHVRAHssPAsLQL; position=ser127; sitegrpid=448847; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=ktANVPQtVPMRLRk; position=thr83; sitegrpid=27460703; ptm=p; direction=d parentid=P46937; parentsymbol=YAP1; site=sGLsMsSySVPRtPD; position=tyr407; sitegrpid=473004; ptm=p; direction=d disease pathway PW:0000013 Pathway Ontology Hippo signaling pathway PW:0001515 Pathway Ontology malignant mesothelioma DOID:1790 Disease 29565815 PubMed Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. 2018 Cancers (Basel) Sekido Y signaling pathway PW:0000003 Pathway Ontology