Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT).
This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org.e3cAMPKAMPKAMPKAMPKAMPKAMPKAMPKCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinCadherinGa/1Ga/1Ga/1Ga/1Ga/1Ga/1PKAPKAPKAPKAPKAPKAPKAPKCPKCPKCPKCPKCPKCPKCPKCPKCPKCPLCBPLCBPLCBPLCBSMADSMADmTORLATS1/2MST1/2LATS1/2Nf2MST1/2Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687parentid=Q9NRM7; parentsymbol=LATS2; site=EHAFyEFtFRRFFDD; position=thr1041;
sitegrpid=31843001; ptm=p; direction=uparentid=O95835; parentsymbol=LATS1; site=EHAFyEFtFRRFFDD; position=thr1079;
sitegrpid=457595; ptm=p; direction=uparentid=P35240; parentsymbol=NF2; site=DTDMKRLsMEIEKEK; position=ser518;
sitegrpid=448282; ptm=p; direction=uparentid=Q13043; parentsymbol=STK4; site=DtMAkRNtVIGTPFW; position=thr183;
sitegrpid=447925; ptm=p; direction=uparentid=Q9GZV5; parentsymbol=WWTR1; site=AQHVRsHssPAsLQL; position=ser89;
sitegrpid=457660; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=PQHVRAHssPAsLQL; position=ser127;
sitegrpid=448847; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=sGLsMsSySVPRtPD; position=tyr407;
sitegrpid=473004; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=ktANVPQtVPMRLRk; position=thr83;
sitegrpid=27460703; ptm=p; direction=dparentid=Q9GZV5; parentsymbol=WWTR1; site=AQHVRsHssPAsLQL; position=ser89;
sitegrpid=457660; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=PQHVRAHssPAsLQL; position=ser127;
sitegrpid=448847; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=ktANVPQtVPMRLRk; position=thr83;
sitegrpid=27460703; ptm=p; direction=dparentid=P46937; parentsymbol=YAP1; site=sGLsMsSySVPRtPD; position=tyr407;
sitegrpid=473004; ptm=p; direction=ddisease pathwayPW:0000013Pathway OntologyHippo signaling pathwayPW:0001515Pathway Ontologymalignant mesotheliomaDOID:1790Disease29565815PubMedTargeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma.2018Cancers (Basel)Sekido Ysignaling pathwayPW:0000003Pathway Ontology