Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung.
Genes altered in small cell lung carcinoma:
* TP53 is mutated in 70-90% of SCLCs.
* RB1 is inactivated in most SCLCs.
* PTEN is mutated in 2-10% of SCLCs.
* MYC amplifications and amplification of MYC family members is found in 30% of SCLCs.
* FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs.
This description was adapted from [https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia].
Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.d45dccCCNE1; cyclin ECCNE2; cyclin ECDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]CCND3; cyclin D3E2F1; E2F transcription factor 1E2F2; E2F transcription factor 2E2F3; E2F transcription factor 3CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112LOHparent=P06400; position=ser249; ptm=p; direction=dparentid=O14920; parentsymbol=IKBKB; site=DQGsLCtsFVGTLQy; position=ser181; sitegrpid=447489; ptm=p; direction=uparentid=P25963; parentsymbol=NFKBIA; site=RHDsGLDsMkDEEyE; position=ser36; sitegrpid=448204; ptm=p; direction=dparentid=P25963; parentsymbol=NFKBIA; site=LLDDRHDsGLDsMkD; position=ser32; sitegrpid=448203; ptm=p; direction=dd67map05222KEGG PathwayKEGG small cell lung cancerhttps://www.kegg.jp/dbget-bin/www_bget?pathway+map05222cancerDOID:162Disease25514926PubMedPhosphoSitePlus, 2014: mutations, PTMs and recalibrations.Nucleic Acids Res2015Hornbeck PVZhang BMurray BKornhauser JMLatham VSkrzypek E17328863PubMedInduction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.Biochem Biophys Res Commun2007Deng WGNishizaki MFang BRoth JAJi Llung cancerDOID:1324Diseasecancer pathwayPW:0000605Pathway Ontologysignaling pathwayPW:0000003Pathway Ontologysmall cell lung carcinoma pathwayPW:0000704Pathway Ontology