Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung. Genes altered in small cell lung carcinoma: * TP53 is mutated in 70-90% of SCLCs. * RB1 is inactivated in most SCLCs. * PTEN is mutated in 2-10% of SCLCs. * MYC amplifications and amplification of MYC family members is found in 30% of SCLCs. * FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs. This description was adapted from [https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. d45 dcc CCNE1; cyclin E CCNE2; cyclin E CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-] CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-] CCND3; cyclin D3 E2F1; E2F transcription factor 1 E2F2; E2F transcription factor 2 E2F3; E2F transcription factor 3 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 LOH parent=P06400; position=ser249; ptm=p; direction=d parentid=O14920; parentsymbol=IKBKB; site=DQGsLCtsFVGTLQy; position=ser181; sitegrpid=447489; ptm=p; direction=u parentid=P25963; parentsymbol=NFKBIA; site=RHDsGLDsMkDEEyE; position=ser36; sitegrpid=448204; ptm=p; direction=d parentid=P25963; parentsymbol=NFKBIA; site=LLDDRHDsGLDsMkD; position=ser32; sitegrpid=448203; ptm=p; direction=d d67 map05222 KEGG Pathway KEGG small cell lung cancer https://www.kegg.jp/dbget-bin/www_bget?pathway+map05222 cancer DOID:162 Disease 25514926 PubMed PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res 2015 Hornbeck PV Zhang B Murray B Kornhauser JM Latham V Skrzypek E 17328863 PubMed Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Biochem Biophys Res Commun 2007 Deng WG Nishizaki M Fang B Roth JA Ji L lung cancer DOID:1324 Disease cancer pathway PW:0000605 Pathway Ontology signaling pathway PW:0000003 Pathway Ontology small cell lung carcinoma pathway PW:0000704 Pathway Ontology