This pathway is inspired by the Lipidmaps>Sphingolipids pathway (all chain lengths) [https://lipidmaps.org/pathway/pathways_maps].
Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.
This pathway shows all different tail lengths and their conversions into specific products. All products are annotated with lipid-specific identifiers (if available).
The general overview pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4344 here].Overview PWf6bb6caka CoA(16:0)b6cb6cAKA Fvt1b6cAKA Lass5f88d60b4aAKA Lass6b4aSM = sphingomyelinSM = sphingomyelinAKA "Coenzyme A, S-docosanoate"AKA "Coenzyme A, S-(tetracosanoate)"AKA "Coenzyme A, S-(15Z)-15-tetracosenoate"b4aOriginal LipidMaps annotationb4aAKA "Coenzyme A, S-hexacosanoate"b4aProtein found in literature (not in original LipidMapsPW)b4aAKA Lass5b4aAKA Lass6b4ab6cSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinSM = sphingomyelinKinetic info: [PMID:17977534]d6db39d6017977534PubMedKinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.FEBS Lett2007Lahiri SLee HMesicek JFuks ZHaimovitz-Friedman AKolesnick RNFuterman AH11756451PubMedCharacterization of murine sphingosine-1-phosphate phosphohydrolase.J Biol Chem2002Le Stunff HPeterson CThornton RMilstien SMandala SMSpiegel Ssphingolipid biosynthetic pathwayPW:0000162Pathway Ontology16100120PubMedLASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.J Biol Chem2005Lahiri SFuterman AHsphingolipid metabolic pathwayPW:0000197Pathway Ontology20923771PubMedA mouse macrophage lipidome.J Biol Chem2010Dennis EADeems RAHarkewicz RQuehenberger OBrown HAMilne SBMyers DSGlass CKHardiman GReichart DMerrill AH JrSullards MCWang EMurphy RCRaetz CRGarrett TAGuan ZRyan ACRussell DWMcDonald JGThompson BMShaw WASud MZhao YGupta SMaurya MRFahy ESubramaniam S15823095PubMedMammalian Lass6 and its related family members regulate synthesis of specific ceramides.Biochem J2005Mizutani YKihara AIgarashi Y26853464PubMedCeramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.J Biol Chem2016Gosejacob DJäger PSVom Dorp KFrejno MCarstensen ACKöhnke MDegen JDörmann PHoch Msphingomyelin metabolic pathwayPW:0000745Pathway Ontology12011104PubMedDe novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.J Biol Chem2002Merrill AH Jr