This pathway is inspired by the Lipidmaps>Sphingolipids pathway (all chain lengths) [https://lipidmaps.org/pathway/pathways_maps]. Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway shows all different tail lengths and their conversions into specific products. All products are annotated with lipid-specific identifiers (if available). The general overview pathway can be found [https://www.wikipathways.org/index.php/Pathway:WP4344 here]. Overview PW f6b b6c aka CoA(16:0) b6c b6c AKA Fvt1 b6c AKA Lass5 f88 d60 b4a AKA Lass6 b4a SM = sphingomyelin SM = sphingomyelin AKA "Coenzyme A, S-​docosanoate" AKA "Coenzyme A, S-​(tetracosanoate)​" AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate" b4a Original LipidMaps annotation b4a AKA "Coenzyme A, S-​hexacosanoate" b4a Protein found in literature (not in original LipidMapsPW) b4a AKA Lass5 b4a AKA Lass6 b4a b6c SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin SM = sphingomyelin Kinetic info: [PMID:17977534] d6d b39 d60 17977534 PubMed Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett 2007 Lahiri S Lee H Mesicek J Fuks Z Haimovitz-Friedman A Kolesnick RN Futerman AH 11756451 PubMed Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem 2002 Le Stunff H Peterson C Thornton R Milstien S Mandala SM Spiegel S sphingolipid biosynthetic pathway PW:0000162 Pathway Ontology 16100120 PubMed LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem 2005 Lahiri S Futerman AH sphingolipid metabolic pathway PW:0000197 Pathway Ontology 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S 15823095 PubMed Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 2005 Mizutani Y Kihara A Igarashi Y 26853464 PubMed Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem 2016 Gosejacob D Jäger PS Vom Dorp K Frejno M Carstensen AC Köhnke M Degen J Dörmann P Hoch M sphingomyelin metabolic pathway PW:0000745 Pathway Ontology 12011104 PubMed De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem 2002 Merrill AH Jr