This pathway is inspired by the Lipidmaps>Sterol lipids expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with Scheme 1 from Acimovic et al (2013 [https://www.ncbi.nlm.nih.gov/pubmed/23558541]).
Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol (Bae et al, 1997[https://www.ncbi.nlm.nih.gov/pubmed/9291139]).
Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well.
The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and differences compared to the original LipidMaps pathway have been coloured turquoise.
This pathway was inferred from Mus musculus pathway [WP4346_106325.gpml] with a 94.0% conversion rate.New PW, homology convertedee1c4eAssuming this is omega 7-typeHomology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153Assuming this is omega-7 typeHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6aka 24-dehydrolathosterolHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166aka Sc4molHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554No homologues found for original id L:320581Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987Annotated while assuming this compound is actually presqualene-diphosphateHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754Assuming this is omega-7 typeHomology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010663Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071No homologues found for original id S:P13011No homologues found for original id En:ENSMUSG00000072949Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226Aka C18:1 (omega 9)C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21HC12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21HC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC=[C@@]21CC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21HHomology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21HC12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21HC12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21Haka 14-demethyl-14-dehydrolanosterolC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILESC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H SMILESHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490multi-step processd66ee1ee1Desmosterol significantly increases protein levels of Nr1h3 (see ref. for more details)f3dee1Multiple steps involvedee1From the LipidMaps drawing, it is unclear if only Nr1h3 influences Srebf1, or the group Nr1h2/3 does this.ee1ee19291139 has been found for Rat, not Mousecbbeb8ee1d66d66d66d66d66ee1ee1ee1ee1ee1ee1ee1ee1multi-step processd66ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1ee1cholesterol biosynthetic pathwayPW:0000454Pathway Ontology20923771PubMedA mouse macrophage lipidome.J Biol Chem2010Dennis EADeems RAHarkewicz RQuehenberger OBrown HAMilne SBMyers DSGlass CKHardiman GReichart DMerrill AH JrSullards MCWang EMurphy RCRaetz CRGarrett TAGuan ZRyan ACRussell DWMcDonald JGThompson BMShaw WASud MZhao YGupta SMaurya MRFahy ESubramaniam S23558541PubMedSteroidal triterpenes of cholesterol synthesis.Molecules2013Ačimovič JRozman D 23558541PubMedSteroidal triterpenes of cholesterol synthesis.Molecules201323558541PubMedSteroidal triterpenes of cholesterol synthesis.Molecules2013Ačimovič JRozman DPubMedSteroidal triterpenes of cholesterol synthesis.Molecules201323558541PubMedSteroidal triterpenes of cholesterol synthesis.Molecules201323558541PubMedSteroidal triterpenes of cholesterol synthesis.Molecules2013Ačimovič JRozman D9291139PubMed9291139PubMedCholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.Biochem J1997Bae SHPaik YK22156476PubMedLiver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.Biol Reprod2012Bogan RLDebarber AEHennebold JDcholesterol metabolic pathwayPW:0001304Pathway Ontologylipid signaling pathwayPW:0000959Pathway Ontology