This pathway is inspired by the Lipidmaps>Sterol lipids expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with Scheme 1 from Acimovic et al (2013 [https://www.ncbi.nlm.nih.gov/pubmed/23558541]). Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol (Bae et al, 1997[https://www.ncbi.nlm.nih.gov/pubmed/9291139]). Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well. The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and differences compared to the original LipidMaps pathway have been coloured turquoise. This pathway was inferred from Mus musculus pathway [WP4346_106325.gpml] with a 94.0% conversion rate. New PW, homology converted ee1 c4e Assuming this is omega 7-type Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153 Assuming this is omega-7 type Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6 aka 24-dehydrolathosterol Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 aka Sc4mol Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554 No homologues found for original id L:320581 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987 Annotated while assuming this compound is actually presqualene-diphosphate Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 Assuming this is omega-7 type Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010663 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071 No homologues found for original id S:P13011 No homologues found for original id En:ENSMUSG00000072949 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226 Aka C18:1 (omega 9) C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC=[C@@]21C C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H aka 14-demethyl-14-dehydrolanosterol C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H SMILES Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 multi-step process d66 ee1 ee1 Desmosterol significantly increases protein levels of Nr1h3 (see ref. for more details) f3d ee1 Multiple steps involved ee1 From the LipidMaps drawing, it is unclear if only Nr1h3 influences Srebf1, or the group Nr1h2/3 does this. ee1 ee1 9291139 has been found for Rat, not Mouse cbb eb8 ee1 d66 d66 d66 d66 d66 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 multi-step process d66 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 ee1 cholesterol biosynthetic pathway PW:0000454 Pathway Ontology 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S 23558541 PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 Ačimovič J Rozman D 23558541 PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 23558541 PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 Ačimovič J Rozman D PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 23558541 PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 23558541 PubMed Steroidal triterpenes of cholesterol synthesis. Molecules 2013 Ačimovič J Rozman D 9291139 PubMed 9291139 PubMed Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J 1997 Bae SH Paik YK 22156476 PubMed Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biol Reprod 2012 Bogan RL Debarber AE Hennebold JD cholesterol metabolic pathway PW:0001304 Pathway Ontology lipid signaling pathway PW:0000959 Pathway Ontology