This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349].
This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes.
Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
This pathway was inferred from Mus musculus pathway [WP4347_106328.gpml] with a 87.0% conversion rate.
New PW, homology converted
a24
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19223
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784
AKA Peroxisome proliferator-activated receptor delta
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
a16
e86
d75
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429
AKA COX-1
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19224
AKA COX-2
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19225
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64292
a16
d75
d75
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19215
a16
e86
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11677
e86
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21391
d75
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43252
a16
AKA Peroxisome proliferator-activated receptor gamma
a16
AKA Prxl2b
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9DB60
a16
AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43117
a16
AKA Peroxisome proliferator-activated receptor gamma
a16
AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P70263
a16
AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9Z2J6
a16
AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P30987
a16
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437
e86
e86
e86
e86
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437
e86
e86
a16
EC:5.3.99.4
a16
d75
a16
a16
a16
e86
e86
a16
EC:1.3.1.48
d75
EC:1.14.99.1
EC:1.14.99.1
EC:5.3.99.3
a16
d75
a16
a16
a16
a16
a16
a16
a16
a16
e86
e86
e86
arachidonic acid metabolic pathway
PW:0000460
Pathway Ontology
eicosanoid biosynthetic pathway
PW:0001239
Pathway Ontology
20923771
PubMed
A mouse macrophage lipidome.
J Biol Chem
2010
Dennis EA
Deems RA
Harkewicz R
Quehenberger O
Brown HA
Milne SB
Myers DS
Glass CK
Hardiman G
Reichart D
Merrill AH Jr
Sullards MC
Wang E
Murphy RC
Raetz CR
Garrett TA
Guan Z
Ryan AC
Russell DW
McDonald JG
Thompson BM
Shaw WA
Sud M
Zhao Y
Gupta S
Maurya MR
Fahy E
Subramaniam S
cyclooxygenase mediated pathway of arachidonic acid metabolism
PW:0000461
Pathway Ontology
18761324
PubMed
New aspects of the role of hydroxyeicosatetraenoicacids in cell growth and cancer development.
Biochem Pharmacol
2009
Moreno JJ
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
inflammatory response pathway
PW:0000024
Pathway Ontology
eicosanoid biosynthetic pathway
PW:0001239
Pathway Ontology
eicosanoid metabolic pathway
PW:0000485
Pathway Ontology
eicosanoid signaling pathway
PW:0000565
Pathway Ontology
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma
PW:0001147
Pathway Ontology