This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids. This pathway was inferred from Mus musculus pathway [WP4347_106328.gpml] with a 87.0% conversion rate. New PW, homology converted a24 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19223 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784 AKA Peroxisome proliferator-activated receptor delta Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396 a16 e86 d75 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429 AKA COX-1 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19224 AKA COX-2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19225 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64292 a16 d75 d75 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19215 a16 e86 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11677 e86 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21391 d75 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43252 a16 AKA Peroxisome proliferator-activated receptor gamma a16 AKA Prxl2b Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9DB60 a16 AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43117 a16 AKA Peroxisome proliferator-activated receptor gamma a16 AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P70263 a16 AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9Z2J6 a16 AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P30987 a16 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437 e86 e86 e86 e86 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437 e86 e86 a16 EC:5.3.99.4 a16 d75 a16 a16 a16 e86 e86 a16 EC:1.3.1.48 d75 EC:1.14.99.1 EC:1.14.99.1 EC:5.3.99.3 a16 d75 a16 a16 a16 a16 a16 a16 a16 a16 e86 e86 e86 arachidonic acid metabolic pathway PW:0000460 Pathway Ontology eicosanoid biosynthetic pathway PW:0001239 Pathway Ontology 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S cyclooxygenase mediated pathway of arachidonic acid metabolism PW:0000461 Pathway Ontology 18761324 PubMed New aspects of the role of hydroxyeicosatetraenoicacids in cell growth and cancer development. Biochem Pharmacol 2009 Moreno JJ 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC inflammatory response pathway PW:0000024 Pathway Ontology eicosanoid biosynthetic pathway PW:0001239 Pathway Ontology eicosanoid metabolic pathway PW:0000485 Pathway Ontology eicosanoid signaling pathway PW:0000565 Pathway Ontology 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma PW:0001147 Pathway Ontology