This pathway is inspired by the [LIPID MAPS>Eicosanoids Pathway expended pathway display](https://lipidmaps.org/pathway/pathways_maps) and extended with the bottom left side of Figure 1 from ([Dennis and Norris (2015)](https://www.ncbi.nlm.nih.gov/pubmed/26139350)). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) [WP4347](https://www.wikipathways.org/pathways/WP4347.html), lipooxygenases(LOX) [WP4348](https://www.wikipathways.org/pathways/WP4348.html), or cytochrome P450 monooxygenases (CYP) [WP4349](https://www.wikipathways.org/pathways/WP4349.html). This pathway visualizes the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids. This pathway was inferred from Mus musculus pathway [WP4349_106330.gpml] with a 64.0% conversion rate. cb4 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13850 AKA Peroxisome proliferator-activated receptor gamma eae eae eae eae eae eae eae eae eae eae Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13095 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13097 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13098 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72082 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054 AKA Peroxisome proliferator-activated receptor alpha Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204 eae eae eae eae eae eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma PW:0001147 Pathway Ontology cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism PW:0000463 Pathway Ontology 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S eicosanoid metabolic pathway PW:0000485 Pathway Ontology