This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps].
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases (LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349].
This pathway visualises the second route, via LOX.
Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
This pathway was inferred from Mus musculus pathway [WP4348_106329.gpml] with a 88.0% conversion rate.
New PW, homology converted
ac2
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993
AKA Leukotriene B4 receptor 1[https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88855
dca
dca
dca
Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936
dca
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689
"Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
"Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
dca
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11687
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
AKA 12S-HpETE
f14
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11684
dca
dca
dca
dca
dca
f14
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
No homologues found for original id L:14598
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23887
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13479
No homologues found for original id L:319446
AKA Ltb4dh
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
AKA Zadh1
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11684
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689
AKA Ltb4dh
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
AKA Zadh1
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993
dca
AKA Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2 [https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JJL9
dca
AKA Peroxisome proliferator-activated receptor alpha
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001
dca
AKA Cysteinyl leukotriene receptor 1, also termed CYSLTR1 [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q99JA4
dca
AKA Cysteinyl leukotriene receptor 2, also termed CYSLTR [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q920A1
dca
dca
dca
dca
AKA N-formyl peptide receptor 2 (FPR2), because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. [https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88536
dca
Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936
dca
Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
dca
Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
dca
f14
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
dca
AKA Peroxisome proliferator-activated receptor alpha
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204
dca
AKA Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ) [https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
dca
AKA Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1 [https://en.wikipedia.org/wiki/TRPA1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8BLA8
dca
AKA The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1 [https://en.wikipedia.org/wiki/TRPV1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q704Y3
dca
AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999
f14
AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999
f14
"Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
f14
AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
f14
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
dca
f14
f14
AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
f14
Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936
dca
Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
dca
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
dca
f14
f14
f14
f14
f14
f14
f14
f14
f14
f14
f14
lipoxygenase mediated pathway of arachidonic acid metabolism
PW:0000462
Pathway Ontology
20923771
PubMed
20923771
PubMed
A mouse macrophage lipidome.
J Biol Chem
2010
Dennis EA
Deems RA
Harkewicz R
Quehenberger O
Brown HA
Milne SB
Myers DS
Glass CK
Hardiman G
Reichart D
Merrill AH Jr
Sullards MC
Wang E
Murphy RC
Raetz CR
Garrett TA
Guan Z
Ryan AC
Russell DW
McDonald JG
Thompson BM
Shaw WA
Sud M
Zhao Y
Gupta S
Maurya MR
Fahy E
Subramaniam S
18761324
PubMed
New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.
Biochem Pharmacol
2009
Moreno JJ
eicosanoid metabolic pathway
PW:0000485
Pathway Ontology
26139350
PubMed
Eicosanoid storm in infection and inflammation.
Nat Rev Immunol
2015
Dennis EA
Norris PC