This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps]. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases (LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the second route, via LOX. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids. This pathway was inferred from Mus musculus pathway [WP4348_106329.gpml] with a 88.0% conversion rate. New PW, homology converted ac2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993 AKA Leukotriene B4 receptor 1[https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88855 dca dca dca Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936 dca dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689 "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid] "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid] dca dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11687 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446 AKA 12S-HpETE f14 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11684 dca dca dca dca dca f14 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 No homologues found for original id L:14598 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23887 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13479 No homologues found for original id L:319446 AKA Ltb4dh Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103 AKA Zadh1 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11684 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689 AKA Ltb4dh Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103 AKA Zadh1 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993 dca AKA Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2 [https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JJL9 dca AKA Peroxisome proliferator-activated receptor alpha Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204 dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001 dca AKA Cysteinyl leukotriene receptor 1, also termed CYSLTR1 [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q99JA4 dca AKA Cysteinyl leukotriene receptor 2, also termed CYSLTR [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q920A1 dca dca dca dca AKA N-formyl peptide receptor 2 (FPR2), because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. [https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88536 dca Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936 dca Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654 dca Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654 dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655 dca f14 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655 dca AKA Peroxisome proliferator-activated receptor alpha Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204 dca AKA Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ) [https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396 dca AKA Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1 [https://en.wikipedia.org/wiki/TRPA1] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8BLA8 dca AKA The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1 [https://en.wikipedia.org/wiki/TRPV1] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q704Y3 dca AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999 f14 AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999 f14 "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid] f14 AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654 f14 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655 dca f14 f14 AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654 f14 Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936 dca Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases] Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654 dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655 dca Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655 dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca dca f14 f14 f14 f14 f14 f14 f14 f14 f14 f14 f14 lipoxygenase mediated pathway of arachidonic acid metabolism PW:0000462 Pathway Ontology 20923771 PubMed 20923771 PubMed A mouse macrophage lipidome. J Biol Chem 2010 Dennis EA Deems RA Harkewicz R Quehenberger O Brown HA Milne SB Myers DS Glass CK Hardiman G Reichart D Merrill AH Jr Sullards MC Wang E Murphy RC Raetz CR Garrett TA Guan Z Ryan AC Russell DW McDonald JG Thompson BM Shaw WA Sud M Zhao Y Gupta S Maurya MR Fahy E Subramaniam S 18761324 PubMed New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol 2009 Moreno JJ eicosanoid metabolic pathway PW:0000485 Pathway Ontology 26139350 PubMed Eicosanoid storm in infection and inflammation. Nat Rev Immunol 2015 Dennis EA Norris PC