This pathway is inspired by the Lipidmaps>Omega-9 and other fatty acids [https://lipidmaps.org/pathway/pathways_maps].
Omega-9 FAs (Fatty acids) are fats which can be obtained from diet, but also produced endogenously. These lipids are monounsaturated (indicating one double bonds in the lipid tail).The position of the double bond is counted from the tail end of the lipid chain.
This pathway also indicated saturated fats (without a double bond), such as stearic acid, arachidic acid etc.
This pathway was inferred from Mus musculus pathway [WP4351_106337.gpml] with a 80.0% conversion rate.
New PW, homology converted
c57
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
AKA SCD2, hSCD2. Soucre: [https://www.uniprot.org/uniprot/Q86SK9].
"highly expressed in brain" [PMID:22745828]; "most abundantly expressed in pancreas and brain" [PMID:15610069], "transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 (aka SCD5, red.) expression is developmentally regulated." [PMID:15610069]
a69
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14104
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:170439
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12686
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54325
No homologues found for original id L:20250 (Scd2) Human ortholog is SCD, which had mouse orthologs Scd2 and Scd4.
"SCD catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA" Source:[https://www.uniprot.org/uniprot/O00767].
"predominantly expressed in liver" [PMID:15610069].
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
No homologues found for original id L:26897
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
No homologues found for original id L:26897
AKA cis-selacholeic acid
AKA cis-selacholeic acid
b4d
fatty acid elongation pathway
PW:0001136
Pathway Ontology
fatty acid metabolic pathway
PW:0000058
Pathway Ontology
20923771
PubMed
A mouse macrophage lipidome.
J Biol Chem
2010
Dennis EA
Deems RA
Harkewicz R
Quehenberger O
Brown HA
Milne SB
Myers DS
Glass CK
Hardiman G
Reichart D
Merrill AH Jr
Sullards MC
Wang E
Murphy RC
Raetz CR
Garrett TA
Guan Z
Ryan AC
Russell DW
McDonald JG
Thompson BM
Shaw WA
Sud M
Zhao Y
Gupta S
Maurya MR
Fahy E
Subramaniam S
15610069
PubMed
Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.
Biochem J
2005
Zhang S
Yang Y
Shi Y
15907797
PubMed
Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.
Biochem Biophys Res Commun
2005
Wang J
Yu L
Schmidt RE
Su C
Huang X
Gould K
Cao G
unsaturated fatty acid biosynthetic pathway
PW:0001137
Pathway Ontology