Congenital hypothyroidism is a genetic hormonal disorder regarding the thyroid hormone. Due dyshormonogenesis, the production of the thyroid hormones is impaired resulting in increased birth weight, reduced LDL breakdown, decreased lipolysis, impaired glucose metabolism and decreased body temperature. Above, an overview of thyroid hormones production occurring in thyroid gland and their relevant downstream signalling is displayed. As the legend states, genes known te be affected by mutations leading to congenital hypothyroidism are colored red. MTORC1 eca e7d eca c13 a79 c93 ddc b42 d09 c32 e8e eca a3e e8e fc4 f7c eca b42 a0d ddc afe f7c e7d cd1 a79 c13 c32 f52 ca5 f7c c13 cd1 c2e c77 f7c cd1 d09 eca c13 b74 ae7 e69 fcf bcd c32 a79 eca b47 c32 b47 b42 c77 cd1 a0d b42 a63 ae7 d70 a09 a63 a79 eca ae1 f06 c13 bcd cd1 b90 c13 a3e d09 d70 a63 f7c f7a eca ae7 b42 eae eca cd1 c32 d70 b42 c32 eca c13 c13 ae0 c32 b7c b74 fc4 c32 ca5 b47 cb9 cd1 e38 c32 afe c32 ddc c13 ab9 a7b bd5 eca c13 cd1 c32 fc4 e38 c32 fc4 b47 cb9 d70 afe a3c cd1 a63 c77 f52 b47 c32 afe b42 c32 f7c cd1 b42 cd1 b7c b47 e38 ae7 cf5 a3c c13 b47 e7d c13 b90 b42 fc4 b47 f52 b42 c77 fc4 b42 b47 b90 c32 ae7 ecc bcd c32 f52 cd1 b42 ae7 c77 c77 cd1 cd1 cd1 b47 b90 be4 be4 be4 e69 f06 a7b bd5 e06 b42 b42 b42 b42 b42 b42 cb1 b42 d70 a7b bd5 a7b bd5 eca Thyroid response element Thyroid response element Thyroid response element Thyroid response element 15971998 PubMed AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. 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