This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of [Jin et. al.](https://pubmed.ncbi.nlm.nih.gov/22406746/). bc9 22406746 PubMed A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med 2012 Jin Y Ratnam K Chuang PY Fan Y Zhong Y Dai Y Mazloom AR Chen EY D'Agati V Xiong H Ross MJ Chen N Ma'ayan A He JC renal fibrosis DOID:0050855 Disease kidney disease pathway PW:0000300 Pathway Ontology