This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2.
This pathway was adapted from Figure 6i of [https://pubmed.ncbi.nlm.nih.gov/22406746/ Jin et. al.]bc9renal fibrosisDOID:0050855Human Disease Ontologykidney disease pathwayPW:0000300Pathway Ontology22406746PubMedA systems approach identifies HIPK2 as a key regulator of kidney fibrosis.Nat Med2012Jin YRatnam KChuang PYFan YZhong YDai YMazloom ARChen EYD'Agati VXiong HRoss MJChen NMa'ayan AHe JC