Overview of purine metabolism. Metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels. This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version including disorders, based on ed. 4, can be found [here](https://www.wikipathways.org/index.php/Pathway:WP4224). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP4792). c52 aka Adenosine deaminase is a nucleoside triphosphate(4−) Adenylosuccinate synthetase isozyme 2 succinyladenosine monophosphate ribonucleotide reductase d0e purine metabolic pathway PW:0000031 Pathway Ontology 10.1016/B978-0-12-405546-9.00005-4 DOI Chapter 5 Combined Immune Deficiencies https://doi.org/10.1016/B978-0-12-405546-9.00005-4 2014 Su, H Lenardo, M. 9783642403378 ISBN Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11 and 41 ISBN 978-3-642-40337-8 2014 Blau, N. Duran, M. Gibson, K.M. Dionisi-Vici, C.