Taken from existing [Endochondral Ossification pathway](https://www.wikipathways.org/pathways/WP474.html) Added diseases linked with a dotted arrow to GeneProduct nodes, dotted arrow indicates what diseases are caused by mutation in the respective genes. e1e fee bfe PMID: 17097081 Taken as homologue to mouse Cathepsin L (Ctsl) Taken as human homologue of mouse Cst10 PMID: 13679380 Direction of effect unclear DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE DISEASE brachydactyly type A1 DOID:0110964 Disease chondrodysplasia Blomstrand type DOID:0060387 Disease metaphyseal dysplasia DOID:0080019 Disease regulatory pathway PW:0000004 Pathway Ontology 23977373 PubMed The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells. PLoS One 2013 Randau TM Schildberg FA Alini M Wimmer MD Haddouti el-M Gravius S Ito K Stoddart MJ metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome DOID:0111513 Disease polydactyly DOID:1148 Disease chondrocyte CL:0000138 Cell Type spondylometaepiphyseal dysplasia, short limb-hand type DOID:0112196 Disease osteoclast CL:0000092 Cell Type osteochondroclast CL:0000093 Cell Type osteogenesis imperfecta DOID:12347 Disease Greig cephalopolysyndactyly syndrome DOID:14761 Disease 18374667 PubMed A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage. Biochim Biophys Acta 2008 Belluoccio D Bernardo BC Rowley L Bateman JF achondroplasia DOID:4480 Disease hypochondroplasia DOID:0080041 Disease spondyloepimetaphyseal dysplasia, Missouri type DOID:0080030 Disease osteoglophonic dysplasia DOID:0111532 Disease camptodactyly-tall stature-scoliosis-hearing loss syndrome DOID:0111160 Disease Jansen's metaphyseal chondrodysplasia DOID:0080020 Disease Eiken syndrome DOID:0111732 Disease Schmid metaphyseal chondrodysplasia DOID:0080021 Disease 17659995 PubMed Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 2008 Mackie EJ Ahmed YA Tatarczuch L Chen KS Mirams M Crouzon syndrome-acanthosis nigricans syndrome DOID:0111161 Disease cleidocranial dysplasia DOID:13994 Disease acrocapitofemoral dysplasia DOID:0050604 Disease Pallister-Hall syndrome DOID:9248 Disease Pfeiffer syndrome DOID:14705 Disease Muenke Syndrome DOID:0060703 Disease