Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentiation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP481 CPTAC Assay Portal] b27 d3b e4b insulin signaling pathway PW:0000143 Pathway Ontology 11742412 PubMed Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001 Saltiel AR Kahn CR 1890850 PubMed A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. J Theor Biol 1991 Quon MJ Campfield LA 11282018 PubMed Insulin signalling. J Cell Sci 2001 Bevan P