Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentiation.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP481 CPTAC Assay Portal]b27d3be4binsulin signaling pathwayPW:0000143Pathway Ontology11742412PubMedInsulin signalling and the regulation of glucose and lipid metabolism.Nature2001Saltiel ARKahn CR1890850PubMedA mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.J Theor Biol1991Quon MJCampfield LA11282018PubMedInsulin signalling.J Cell Sci2001Bevan P