GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct. This pathway was inferred from Mus musculus pathway [WP4820_109222.gpml] with a 100.0% conversion rate. GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct. Pathway converted from original mouse pathway WP4820. c1e Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35546 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97785 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037211 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050295 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025902 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025932 f46 f55 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063632 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004231 f46 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031665 f46 f27 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000068122 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046714 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022144 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015619 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046743 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052516 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q61602 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021835 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D0P8 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D6H2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018698 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031558 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q02248 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000074934 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022144 fda Maintenance of the nephric duct regulatory pathway PW:0000004 Pathway Ontology 15141091 PubMed SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A 2004 Ruf RG Xu PX Silvius D Otto EA Beekmann F Muerb UT Kumar S Neuhaus TJ Kemper MJ Raymond RM Jr Brophy PD Berkman J Gattas M Hyland V Ruf EM Schwartz C Chang EH Smith RJ Stratakis CA Weil D Petit C Hildebrandt F 9361030 PubMed Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1. Hum Mol Genet 1997 Abdelhak S Kalatzis V Heilig R Compain S Samson D Vincent C Levi-Acobas F Cruaud C Le Merrer M Mathieu M König R Vigneron J Weissenbach J Petit C Weil D 16971658 PubMed Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J Am Soc Nephrol 2006 Weber S Moriniere V Knüppel T Charbit M Dusek J Ghiggeri GM Jankauskiené A Mir S Montini G Peco-Antic A Wühl E Zurowska AM Mehls O Antignac C Schaefer F Salomon R 9425907 PubMed Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome. Nat Genet 1998 Kohlhase J Wischermann A Reichenbach H Froster U Engel W CAKUT DOID:0080205 Disease 32030122 PubMed Duplex kidney formation: developmental mechanisms and genetic predisposition. F1000Res 2020 Kozlov VM Schedl A