Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1 NetPath 13: IL-1 Signaling Pathway
 NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published. http://www.netpath.org This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP244&oldid=21193 WP244(r21193)] with a 98% conversion rate.

integrin mediated signaling pathway PW:0000286 Pathway Ontology