Neuroinflammation is inflammation specific to parts of the central nervous system. It can be triggered by external or internal factors, such as UV damage, inflammatory cytokines and oxidative stress. Stress on the cell leads to activation of inflammatory response pathways that involve several transcription factors such as AP-1 and NFkB, which will lead to the transcription of several proteins and/or cytokines.b6aa51ebfstress response pathwayPW:0000237Pathway Ontology29158945PubMedNF-κB signaling in inflammation.Signal Transduct Target Ther2017Liu TZhang LJoo DSun SC25012593PubMedInhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.J Mol Neurosci2015Xing BBachstetter ADVan Eldik LJregulatory pathway pertinent to the brainPW:0001251Pathway Ontology27412492PubMedNeuroinflammation pathways: a general review.Int J Neurosci2017Shabab TKhanabdali RMoghadamtousi SZKadir HAMohan G