The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
Converted to human by GenMAPP.org
This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP382&oldid=28779 WP382(r28779)] with a 91% conversion rate.
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mitogen activated protein kinase signaling pathway
PW:0000007
Pathway Ontology
11749383
PubMed
MAP kinases.
Chem Rev
2001
Chen Z
Gibson TB
Robinson F
Silvestro L
Pearson G
Xu B
Wright A
Vanderbilt C
Cobb MH
12191611
PubMed
Docking interactions in the mitogen-activated protein kinase cascades.
Pharmacol Ther
2002
Tanoue T
Nishida E
12947395
PubMed
MAPK pathways in radiation responses.
Oncogene
2003
Dent P
Yacoub A
Fisher PB
Hagan MP
Grant S
12676795
PubMed
Trk receptors: roles in neuronal signal transduction.
Annu Rev Biochem
2003
Huang EJ
Reichardt LF
11369511
PubMed
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Cell Signal
2001
Harper SJ
LoGrasso P
12390245
PubMed
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Genes Cells
2002
Takeda K
Ichijo H
14597384
PubMed
Transcriptional regulation by the MAP kinase signaling cascades.
Gene
2003
Yang SH
Sharrocks AD
Whitmarsh AJ
12566928
PubMed
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Neurosignals
2002
Zhu X
Lee HG
Raina AK
Perry G
Smith MA
12849693
PubMed
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Toxicol Lett
2003
Cho H
Lee J
Kwak NJ
Lee KH
Rha S
Kim YH
Cho YY
Yang KH
Kim K
Lim Y
10618718
PubMed
Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation.
Oncogene
1999
Garcia-Guzman M
Dolfi F
Zeh K
Vuori K
21384452
PubMed
GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2.
Protein Sci
2011
Thévenin AF
Zony CL
Bahnson BJ
Colman RF
17726008
PubMed
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
J Biol Chem
2007
Abell AN
Granger DA
Johnson GL