Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.
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20231451
PubMed
Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways.
Proc Natl Acad Sci U S A
2010
Ren H
Accili D
Duan C
22764051
PubMed
Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation.
Development
2012
Liu W
Wen Y
Bi P
Lai X
Liu XS
Liu X
Kuang S
17717603
PubMed
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
J Clin Invest
2007
Kitamura T
Kitamura YI
Funahashi Y
Shawber CJ
Castrillon DH
Kollipara R
DePinho RA
Kitajewski J
Accili D
20819939
PubMed
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7.
J Cell Biol
2010
Chen JF
Tao Y
Li J
Deng Z
Yan Z
Xiao X
Wang DZ
30970214
PubMed
Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.
FASEB J
2019
Sinha KM
Tseng C
Guo P
Lu A
Pan H
Gao X
Andrews R
Eltzschig H
Huard J
Notch signaling pathway
PW:0000204
Pathway Ontology
Wnt signaling pathway
PW:0000008
Pathway Ontology
26708096
PubMed
Muscle-specific microRNAs in skeletal muscle development.
Dev Biol
2016
Horak M
Novak J
Bienertova-Vasku J
22006022
PubMed
O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.
Mol Cell Biol
2012
Majmundar AJ
Skuli N
Mesquita RC
Kim MN
Yodh AG
Nguyen-McCarty M
Simon MC
myoblast
CL:0000056
Cell Type
17395396
PubMed
Effects of hypoxia on proliferation and differentiation of myoblasts.
Med Hypotheses
2007
Li X
Zhu L
Chen X
Fan M
14754880
PubMed
Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation.
J Biol Chem
2004
Di Carlo A
De Mori R
Martelli F
Pompilio G
Capogrossi MC
Germani A
21041476
PubMed
miR-206 and -486 induce myoblast differentiation by downregulating Pax7.
Mol Cell Biol
2011
Dey BK
Gagan J
Dutta A