SARS-CoV-2 Innate immunity evasion mechanisms and cell-specific immune responses; Metabolic overview over ATII cells infection c4e Basigin GM-CSF TIM3 Caspase-8 Binds to 5' PPP RNA region P ba1 c4e a88 c4e c4e bbc f42 c4e bbc bbc c4e c1f c6d e56 Immunoglobulin A (IgA) can bind to the S1 domain of the SARS-CoV-2 spike protein leading to an early burst of IgA that may eliminate the virus in the respiratory mucosa and prevent the development of full adaptive immune response. e5d c4e bbc c4e c6d c4e Immunolobulin M can bind to the RBD of the S1 domain of the SARS-CoV-2, acting as primary immune response. e5d c4e bbc bbc bbc bbc dd1 bbc ec1 bbc c96 c58 bbc a88 c4e c4e ba1 a88 c4e dd1 d77 c71 ba8 bbc bbc The increase of TGFß production induces the IgA isotype switch. e5d bbc c04 bbc High levels of viral load stimulate TGFß production, which is locally secreted. e5d c4e TGF-beta signalling pathway enhanced; Observed in SARS-CoV hypothesises to be conserved in SARS-CoV-2 bbc c4e aed bbc ec1 c4e ba1 c4e ba1 bbc bbc bbc c4e bbc c4e c4e c96 Including MX1, IFTM1, IFIT2 33335518 PubMed COVID-19: The Emerging Immunopathological Determinants for Recovery or Death. Front Microbiol 2020 Ahmad T Chaudhuri R Joshi MC Almatroudi A Rahmani AH Ali SM 33335518 PubMed COVID-19: The Emerging Immunopathological Determinants for Recovery or Death. Front Microbiol 2020 Ahmad T Chaudhuri R Joshi MC Almatroudi A Rahmani AH Ali SM disease pathway PW:0000013 Pathway Ontology natural killer cell CL:0000623 Cell Type 10.2139/ssrn.3555695 DOI Viral invasion and Type I interferon response characterize the immunophenotypes during COVID-19 infection Epub ahead of print 2020 Wei, L. Ming, S. Zou, B. Wu, Y. Hong, Z. Li, Z. et al. 10.1101/2020.03.14.988345 DOI SARS-CoV2 invades host cells via a el route: CD147-spike protein bioRxiv 2020 Wang K Chen W Zhou Y-S Lian J-Q Zhang Z Du P et al. 15580300 PubMed Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively. Oncogene 2005 Porta C Hadj-Slimane R Nejmeddine M Pampin M Tovey MG Espert L Alvarez S Chelbi-Alix MK 32353859 PubMed A SARS-CoV-2 protein interaction map reveals targets for drug repurposing Nature 2020 Gordon, D. E. Jang, G. M. Bouhaddou, M. Xu, J. Obernier, K. White, K. M. et al. neutrophil CL:0000775 Cell Type 32555321 PubMed The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell Mol Immunol 2020 Ren Y Shu T Wu D Mu J Wang C Huang M Han Y Zhang XY Zhou W Qiu Y Zhou X 26579391 PubMed Recent advances in the anti-HCV mechanisms of interferon. Acta Pharm Sin B 2014 Huang M Jiang JD Peng Z severe acute respiratory syndrome DOID:2945 Disease 33335518 PubMed COVID-19: The Emerging Immunopathological Determinants for Recovery or Death. Front Microbiol 2020 Ahmad T Chaudhuri R Joshi MC Almatroudi A Rahmani AH Ali SM 32529952 PubMed SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists. Emerg. Microbes Infect. 2020 Yuen, C. K. Lam, J. Y. Wong, W. M. Mak, L. F. Wang, X. Chu, H. et al. 10.1101/2020.04.19.20068015 DOI Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. medRxiv 2020 Hadjadj, J. Yatim, N. Barnabei, L. Corneau, A. Boussier, J. Pere, H. et al immune response pathway PW:0000023 Pathway Ontology 32529952 PubMed SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists Emerg Microbes Infect. 2020 Chun-Kit Yuen Joy-Yan Lam Wan-Man Wong Long-Fung Mak Xiaohui Wang Hin Chu Jian-Piao Cai Dong-Yan Jin Kelvin Kai-Wang To Jasper Fuk-Woo Chan Kwok-Yung Yuen Kin-Hang Kok 19430490 PubMed Coronaviruses post-SARS: update on replication and pathogenesis Nat Rev Microbiol. 2009 Stanley Perlman Jason Netland 17490702 PubMed Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB. Virology Zhang X Wu K. Wang D. Yue X. Song D. Zhu Y. et al. 32416070 PubMed Imbalanced host response to SARS-CoV-2 drives development of COVID-19 Cell 2020 Blanco-Melo, D. Nilsson-Payant, B. E. Liu, W. C. Uhl, S. Hoagland, D. Møller, R. et al. 31986264 PubMed Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet 2020 Huang, C. Wang, Y. Li, X. Ren, L. Zhao, J. Hu, Y. et al. 10.1101/2020.08.03.234559 DOI SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98 bioRxiv 2020 Addetia, A. Lieberman, N. P. Phung, Q. Xie, H. Roychoudhury, P. Loprieno, M. A. et al. 33391280 PubMed Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases. Front Immunol 2020 Carsetti R Zaffina S Piano Mortari E Terreri S Corrente F Capponi C Palomba P Mirabella M Cascioli S Palange P Cuccaro I Milito C Zumla A Maeurer M Camisa V Vinci MR Santoro A Cimini E Marchioni L Nicastri E Palmieri F Agrati C Ippolito G Porzio O Concato C Onetti Muda A Raponi M Quintarelli C Quinti I Locatelli F 33335518 PubMed COVID-19: The Emerging Immunopathological Determinants for Recovery or Death. Front Microbiol 2020 Ahmad T Chaudhuri R Joshi MC Almatroudi A Rahmani AH Ali SM 32353859 PubMed A SARS-CoV-2 protein interaction map reveals targets for drug repurposing Nature 2020 Gordon, D. E. Jang, G. M. Bouhaddou, M. Xu, J. Obernier, K. White, K. M. et al. COVID-19 DOID:0080600 Disease 33372174 PubMed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling bioRxiv 2020 Zheng Y. Zhuang M-W. Han L. Zhang J. Nan M-L. Gao C. et al. 33101306 PubMed Covid-19: Perspectives on Innate Immune Evasion. Front Immunol 2020 Taefehshokr N Taefehshokr S Hemmat N Heit B pulmonary alveolar type 2 cell CL:0002063 Cell Type 32353859 PubMed A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 2020 Gordon DE Jang GM Bouhaddou M Xu J Obernier K White KM O'Meara MJ Rezelj VV Guo JZ Swaney DL Tummino TA Hüttenhain R Kaake RM Richards AL Tutuncuoglu B Foussard H Batra J Haas K Modak M Kim M Haas P Polacco BJ Braberg H Fabius JM Eckhardt M Soucheray M Bennett MJ Cakir M McGregor MJ Li Q Meyer B Roesch F Vallet T Mac Kain A Miorin L Moreno E Naing ZZC Zhou Y Peng S Shi Y Zhang Z Shen W Kirby IT Melnyk JE Chorba JS Lou K Dai SA Barrio-Hernandez I Memon D Hernandez-Armenta C Lyu J Mathy CJP Perica T Pilla KB Ganesan SJ Saltzberg DJ Rakesh R Liu X Rosenthal SB Calviello L Venkataramanan S Liboy-Lugo J Lin Y Huang XP Liu Y Wankowicz SA Bohn M Safari M Ugur FS Koh C Savar NS Tran QD Shengjuler D Fletcher SJ O'Neal MC Cai Y Chang JCJ Broadhurst DJ Klippsten S Sharp PP Wenzell NA Kuzuoglu-Ozturk D Wang HY Trenker R Young JM Cavero DA Hiatt J Roth TL Rathore U Subramanian A Noack J Hubert M Stroud RM Frankel AD Rosenberg OS Verba KA Agard DA Ott M Emerman M Jura N von Zastrow M Verdin E Ashworth A Schwartz O d'Enfert C Mukherjee S Jacobson M Malik HS Fujimori DG Ideker T Craik CS Floor SN Fraser JS Gross JD Sali A Roth BL Ruggero D Taunton J Kortemme T Beltrao P Vignuzzi M García-Sastre A Shokat KM Shoichet BK Krogan NJ macrophage CL:0000235 Cell Type