This pathway describes the gene signaling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract). dc2 cd5 kidney disease DOID:557 Disease Notch signaling pathway PW:0000204 Pathway Ontology 23520208 PubMed Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling. J Am Soc Nephrol 2013 Vivante A Mark-Danieli M Davidovits M Harari-Steinberg O Omer D Gnatek Y Cleper R Landau D Kovalski Y Weissman I Eisenstein I Soudack M Wolf HR Issler N Lotan D Anikster Y Dekel B signaling pathway PW:0000003 Pathway Ontology CAKUT DOID:0080205 Disease 17229764 PubMed Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 2007 Cheng HT Kim M Valerius MT Surendran K Schuster-Gossler K Gossler A McMahon AP Kopan R