This pathway describes the gene signalling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).cd5dc2kidney diseaseDOID:557Human Disease OntologyNotch signaling pathwayPW:0000204Pathway Ontologysignaling pathwayPW:0000003Pathway OntologyCAKUTDOID:0080205Human Disease Ontology23520208PubMedRenal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.J Am Soc Nephrol2013Vivante AMark-Danieli MDavidovits MHarari-Steinberg OOmer DGnatek YCleper RLandau DKovalski YWeissman IEisenstein ISoudack MWolf HRIssler NLotan DAnikster YDekel B17229764PubMedNotch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.Development2007Cheng HTKim MValerius MTSurendran KSchuster-Gossler KGossler AMcMahon APKopan R