This pathway describes the gene signalling pathway active in the development of the ureteric collection system in human kidney development. Mutations in essential genes within this pathway can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract). fde c94 c94 ae4 found only in mouse so far CyclinD1 c0a e0b e9a ae4 c4e found only in mouse so far found only in mouse so far N-MYC found only in mouse so far also known as KAL-1, KAL1 c7b f3e e33 e33 d99 a43 e33 found only in mouse so far e33 fac e33 found only in mouse so far bfb c0a e09 b39 c57 bbc ce8 c9e de7 bbc a40 Evidence in mouse only f5a bbc b51 bbc bbc cf3 b39 ce8 ce3 eca bbc cf3 e16 ce8 be8 db3 a40 bfb b39 b39 de7 bbc bbc bbc bbc bbc ce8 cf3 signaling pathway PW:0000003 Pathway Ontology kidney disease DOID:557 Human Disease Ontology CAKUT DOID:0080205 Human Disease Ontology 18787044 PubMed Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. 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