This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.
bfc
ec2
a09
bfe
bfc
bdc
bfc
bdc
c58
bdc
c58
bfc
bdc
bfc
bdc
bfc
bdc
bfc
bdc
d7d
bdc
bfc
bfc
bdc
c58
bfc
bdc
c58
bfc
bdc
bfc
bdc
bfc
bdc
bfc
bdc
bfc
bdc
d44
cf2
d44
c9c
da3
bfc
ab7
bfc
bfc
bfc
ab7
bfc
bfc
c9c
bfc
ad4
bfc
c9c
c58
bfc
bfc
bfc
bfc
bfc
bfc
bfc
bfc
d40
d40
d2b
d2b
d2b
d2b
bd5
a73
cd7
d2b
c58
a73
e05
c58
d9f
f9c
d9f
d40
ad4
32838362
PubMed
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.
Med (N Y)
2021
Li J
Guo M
Tian X
Wang X
Yang X
Wu P
Liu C
Xiao Z
Qu Y
Yin Y
Wang C
Zhang Y
Zhu Z
Liu Z
Peng C
Zhu T
Liang Q
32619549
PubMed
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.
Cell Syst
2020
Messner CB
Demichev V
Wendisch D
Michalick L
White M
Freiwald A
Textoris-Taube K
Vernardis SI
Egger AS
Kreidl M
Ludwig D
Kilian C
Agostini F
Zelezniak A
Thibeault C
Pfeiffer M
Hippenstiel S
Hocke A
von Kalle C
Campbell A
Hayward C
Porteous DJ
Marioni RE
Langenberg C
Lilley KS
Kuebler WM
Mülleder M
Drosten C
Suttorp N
Witzenrath M
Kurth F
Sander LE
Ralser M
10.1038/s41467-020-17665-9
DOI
Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.
Biochem Biophys Res Commun
1975
Schmoldt A
Benthe HF
Haberland G
Jallon JM
Risler Y
Iwatsubo M
10.1101/2020.05.09.086165
DOI
Rat prostate carcinoma 11095-A: profile of organ- and tumor-specific antigens.
Natl Cancer Inst Monogr
1978
Schmoldt A
Benthe HF
Haberland G
Adzerikho RD
Aksentsev SL
Okun' IM
Konev SV
Durbin RP
Hendrickson WA
Ward KB
Marniemi J
Parkki MG
Lande IJ
Feldbush TL
Lubaroff DM
Bonney WW
32132184
PubMed
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
Science
2020
Yan R
Zhang Y
Li Y
Xia L
Guo Y
Zhou Q
32307550
PubMed
Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19.
Clin Infect Dis
2020
Ouyang Y
Yin J
Wang W
Shi H
Shi Y
Xu B
Qiao L
Feng Y
Pang L
Wei F
Guo X
Jin R
Chen D
32492406
PubMed
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.
Cell
2020
Shen B
Yi X
Sun Y
Bi X
Du J
Zhang C
Quan S
Zhang F
Sun R
Qian L
Ge W
Liu W
Liang S
Chen H
Zhang Y
Li J
Xu J
He Z
Chen B
Wang J
Yan H
Zheng Y
Wang D
Zhu J
Kong Z
Kang Z
Liang X
Ding X
Ruan G
Xiang N
Cai X
Gao H
Li L
Li S
Xiao Q
Lu T
Zhu Y
Liu H
Guo T
disease pathway
PW:0000013
Pathway Ontology
32979938
PubMed
Evasion of Type I Interferon by SARS-CoV-2.
Cell Rep
2020
Xia H
Cao Z
Xie X
Zhang X
Chen JY
Wang H
Menachery VD
Rajsbaum R
Shi PY
32573711
PubMed
Platelet gene expression and function in patients with COVID-19.
Blood
2020
Manne BK
Denorme F
Middleton EA
Portier I
Rowley JW
Stubben C
Petrey AC
Tolley ND
Guo L
Cody M
Weyrich AS
Yost CC
Rondina MT
Campbell RA
32555321
PubMed
The ORF3a protein of SARS-CoV-2 induces apoptosis in cells.
Cell Mol Immunol
2020
Ren Y
Shu T
Wu D
Mu J
Wang C
Huang M
Han Y
Zhang XY
Zhou W
Qiu Y
Zhou X
33422265
PubMed
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Dev Cell
2021
Miao G
Zhao H
Li Y
Ji M
Chen Y
Shi Y
Bi Y
Wang P
Zhang H
32733001
PubMed
Activation and evasion of type I interferon responses by SARS-CoV-2.
Nat Commun
2020
Lei X
Dong X
Ma R
Wang W
Xiao X
Tian Z
Wang C
Wang Y
Li L
Ren L
Guo F
Zhao Z
Zhou Z
Xiang Z
Wang J
32228226
PubMed
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Emerg Microbes Infect
2020
Xiong Y
Liu Y
Cao L
Wang D
Guo M
Jiang A
Guo D
Hu W
Yang J
Tang Z
Wu H
Lin Y
Zhang M
Zhang Q
Shi M
Zhou Y
Lan K
Chen Y
33845483
PubMed
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
Nature
2021
Stukalov A
Girault V
Grass V
Karayel O
Bergant V
Urban C
Haas DA
Huang Y
Oubraham L
Wang A
Hamad MS
Piras A
Hansen FM
Tanzer MC
Paron I
Zinzula L
Engleitner T
Reinecke M
Lavacca TM
Ehmann R
Wölfel R
Jores J
Kuster B
Protzer U
Rad R
Ziebuhr J
Thiel V
Scaturro P
Mann M
Pichlmair A
32376634
PubMed
Cell entry mechanisms of SARS-CoV-2.
Proc Natl Acad Sci U S A
2020
Shang J
Wan Y
Luo C
Ye G
Geng Q
Auerbach A
Li F
32416070
PubMed
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Cell
2020
Blanco-Melo D
Nilsson-Payant BE
Liu WC
Uhl S
Hoagland D
Møller R
Jordan TX
Oishi K
Panis M
Sachs D
Wang TT
Schwartz RE
Lim JK
Albrecht RA
tenOever BR
32691695
PubMed
Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.
Emerg Microbes Infect
2020
Appelberg S
Gupta S
Svensson Akusjärvi S
Ambikan AT
Mikaeloff F
Saccon E
Végvári �
Benfeitas R
Sperk M
Ståhlberg M
Krishnan S
Singh K
Penninger JM
Mirazimi A
Neogi U
32048163
PubMed
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.
Sci China Life Sci
2020
Liu Y
Yang Y
Zhang C
Huang F
Wang F
Yuan J
Wang Z
Li J
Feng C
Zhang Z
Wang L
Peng L
Chen L
Qin Y
Zhao D
Tan S
Yin L
Xu J
Zhou C
Jiang C
Liu L
32511476
PubMed
Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.
medRxiv
2020
Mick E
Kamm J
Pisco AO
Ratnasiri K
Babik JM
Calfee CS
Castañeda G
DeRisi JL
Detweiler AM
Hao S
Kangelaris KN
Kumar GR
Li LM
Mann SA
Neff N
Prasad PA
Serpa PH
Shah SJ
Spottiswoode N
Tan M
Christenson SA
Kistler A
Langelier C
severe acute respiratory syndrome
DOID:2945
Disease
32353859
PubMed
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature
2020
Gordon DE
Jang GM
Bouhaddou M
Xu J
Obernier K
White KM
O'Meara MJ
Rezelj VV
Guo JZ
Swaney DL
Tummino TA
Hüttenhain R
Kaake RM
Richards AL
Tutuncuoglu B
Foussard H
Batra J
Haas K
Modak M
Kim M
Haas P
Polacco BJ
Braberg H
Fabius JM
Eckhardt M
Soucheray M
Bennett MJ
Cakir M
McGregor MJ
Li Q
Meyer B
Roesch F
Vallet T
Mac Kain A
Miorin L
Moreno E
Naing ZZC
Zhou Y
Peng S
Shi Y
Zhang Z
Shen W
Kirby IT
Melnyk JE
Chorba JS
Lou K
Dai SA
Barrio-Hernandez I
Memon D
Hernandez-Armenta C
Lyu J
Mathy CJP
Perica T
Pilla KB
Ganesan SJ
Saltzberg DJ
Rakesh R
Liu X
Rosenthal SB
Calviello L
Venkataramanan S
Liboy-Lugo J
Lin Y
Huang XP
Liu Y
Wankowicz SA
Bohn M
Safari M
Ugur FS
Koh C
Savar NS
Tran QD
Shengjuler D
Fletcher SJ
O'Neal MC
Cai Y
Chang JCJ
Broadhurst DJ
Klippsten S
Sharp PP
Wenzell NA
Kuzuoglu-Ozturk D
Wang HY
Trenker R
Young JM
Cavero DA
Hiatt J
Roth TL
Rathore U
Subramanian A
Noack J
Hubert M
Stroud RM
Frankel AD
Rosenberg OS
Verba KA
Agard DA
Ott M
Emerman M
Jura N
von Zastrow M
Verdin E
Ashworth A
Schwartz O
d'Enfert C
Mukherjee S
Jacobson M
Malik HS
Fujimori DG
Ideker T
Craik CS
Floor SN
Fraser JS
Gross JD
Sali A
Roth BL
Ruggero D
Taunton J
Kortemme T
Beltrao P
Vignuzzi M
GarcÃÂÂa-Sastre A
Shokat KM
Shoichet BK
Krogan NJ
32838362
PubMed
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.
Med (N Y)
2021
Li J
Guo M
Tian X
Wang X
Yang X
Wu P
Liu C
Xiao Z
Qu Y
Yin Y
Wang C
Zhang Y
Zhu Z
Liu Z
Peng C
Zhu T
Liang Q
respiratory system disease pathway
PW:0001308
Pathway Ontology
32555321
PubMed
Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.
Biochem Biophys Res Commun
1975
Schmoldt A
Benthe HF
Haberland G
Jallon JM
Risler Y
Iwatsubo M