This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included. bfc ec2 a09 bfe bfc bdc bfc bdc c58 bdc c58 bfc bdc bfc bdc bfc bdc bfc bdc d7d bdc bfc bfc bdc c58 bfc bdc c58 bfc bdc bfc bdc bfc bdc bfc bdc bfc bdc d44 cf2 d44 c9c da3 bfc ab7 bfc bfc bfc ab7 bfc bfc c9c bfc ad4 bfc c9c c58 bfc bfc bfc bfc bfc bfc bfc bfc d40 d40 d2b d2b d2b d2b bd5 a73 cd7 d2b c58 a73 e05 c58 d9f f9c d9f d40 ad4 32838362 PubMed Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Med (N Y) 2021 Li J Guo M Tian X Wang X Yang X Wu P Liu C Xiao Z Qu Y Yin Y Wang C Zhang Y Zhu Z Liu Z Peng C Zhu T Liang Q 32619549 PubMed Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Cell Syst 2020 Messner CB Demichev V Wendisch D Michalick L White M Freiwald A Textoris-Taube K Vernardis SI Egger AS Kreidl M Ludwig D Kilian C Agostini F Zelezniak A Thibeault C Pfeiffer M Hippenstiel S Hocke A von Kalle C Campbell A Hayward C Porteous DJ Marioni RE Langenberg C Lilley KS Kuebler WM Mülleder M Drosten C Suttorp N Witzenrath M Kurth F Sander LE Ralser M 10.1038/s41467-020-17665-9 DOI Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH. Biochem Biophys Res Commun 1975 Schmoldt A Benthe HF Haberland G Jallon JM Risler Y Iwatsubo M 10.1101/2020.05.09.086165 DOI Rat prostate carcinoma 11095-A: profile of organ- and tumor-specific antigens. Natl Cancer Inst Monogr 1978 Schmoldt A Benthe HF Haberland G Adzerikho RD Aksentsev SL Okun' IM Konev SV Durbin RP Hendrickson WA Ward KB Marniemi J Parkki MG Lande IJ Feldbush TL Lubaroff DM Bonney WW 32132184 PubMed Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 2020 Yan R Zhang Y Li Y Xia L Guo Y Zhou Q 32307550 PubMed Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19. Clin Infect Dis 2020 Ouyang Y Yin J Wang W Shi H Shi Y Xu B Qiao L Feng Y Pang L Wei F Guo X Jin R Chen D 32492406 PubMed Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell 2020 Shen B Yi X Sun Y Bi X Du J Zhang C Quan S Zhang F Sun R Qian L Ge W Liu W Liang S Chen H Zhang Y Li J Xu J He Z Chen B Wang J Yan H Zheng Y Wang D Zhu J Kong Z Kang Z Liang X Ding X Ruan G Xiang N Cai X Gao H Li L Li S Xiao Q Lu T Zhu Y Liu H Guo T disease pathway PW:0000013 Pathway Ontology 32979938 PubMed Evasion of Type I Interferon by SARS-CoV-2. Cell Rep 2020 Xia H Cao Z Xie X Zhang X Chen JY Wang H Menachery VD Rajsbaum R Shi PY 32573711 PubMed Platelet gene expression and function in patients with COVID-19. Blood 2020 Manne BK Denorme F Middleton EA Portier I Rowley JW Stubben C Petrey AC Tolley ND Guo L Cody M Weyrich AS Yost CC Rondina MT Campbell RA 32555321 PubMed The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell Mol Immunol 2020 Ren Y Shu T Wu D Mu J Wang C Huang M Han Y Zhang XY Zhou W Qiu Y Zhou X 33422265 PubMed ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Dev Cell 2021 Miao G Zhao H Li Y Ji M Chen Y Shi Y Bi Y Wang P Zhang H 32733001 PubMed Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun 2020 Lei X Dong X Ma R Wang W Xiao X Tian Z Wang C Wang Y Li L Ren L Guo F Zhao Z Zhou Z Xiang Z Wang J 32228226 PubMed Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg Microbes Infect 2020 Xiong Y Liu Y Cao L Wang D Guo M Jiang A Guo D Hu W Yang J Tang Z Wu H Lin Y Zhang M Zhang Q Shi M Zhou Y Lan K Chen Y 33845483 PubMed Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 2021 Stukalov A Girault V Grass V Karayel O Bergant V Urban C Haas DA Huang Y Oubraham L Wang A Hamad MS Piras A Hansen FM Tanzer MC Paron I Zinzula L Engleitner T Reinecke M Lavacca TM Ehmann R Wölfel R Jores J Kuster B Protzer U Rad R Ziebuhr J Thiel V Scaturro P Mann M Pichlmair A 32376634 PubMed Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci U S A 2020 Shang J Wan Y Luo C Ye G Geng Q Auerbach A Li F 32416070 PubMed Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell 2020 Blanco-Melo D Nilsson-Payant BE Liu WC Uhl S Hoagland D Møller R Jordan TX Oishi K Panis M Sachs D Wang TT Schwartz RE Lim JK Albrecht RA tenOever BR 32691695 PubMed Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect 2020 Appelberg S Gupta S Svensson Akusjärvi S Ambikan AT Mikaeloff F Saccon E Végvári � Benfeitas R Sperk M Ståhlberg M Krishnan S Singh K Penninger JM Mirazimi A Neogi U 32048163 PubMed Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci 2020 Liu Y Yang Y Zhang C Huang F Wang F Yuan J Wang Z Li J Feng C Zhang Z Wang L Peng L Chen L Qin Y Zhao D Tan S Yin L Xu J Zhou C Jiang C Liu L 32511476 PubMed Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv 2020 Mick E Kamm J Pisco AO Ratnasiri K Babik JM Calfee CS Castañeda G DeRisi JL Detweiler AM Hao S Kangelaris KN Kumar GR Li LM Mann SA Neff N Prasad PA Serpa PH Shah SJ Spottiswoode N Tan M Christenson SA Kistler A Langelier C severe acute respiratory syndrome DOID:2945 Disease 32353859 PubMed A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 2020 Gordon DE Jang GM Bouhaddou M Xu J Obernier K White KM O'Meara MJ Rezelj VV Guo JZ Swaney DL Tummino TA Hüttenhain R Kaake RM Richards AL Tutuncuoglu B Foussard H Batra J Haas K Modak M Kim M Haas P Polacco BJ Braberg H Fabius JM Eckhardt M Soucheray M Bennett MJ Cakir M McGregor MJ Li Q Meyer B Roesch F Vallet T Mac Kain A Miorin L Moreno E Naing ZZC Zhou Y Peng S Shi Y Zhang Z Shen W Kirby IT Melnyk JE Chorba JS Lou K Dai SA Barrio-Hernandez I Memon D Hernandez-Armenta C Lyu J Mathy CJP Perica T Pilla KB Ganesan SJ Saltzberg DJ Rakesh R Liu X Rosenthal SB Calviello L Venkataramanan S Liboy-Lugo J Lin Y Huang XP Liu Y Wankowicz SA Bohn M Safari M Ugur FS Koh C Savar NS Tran QD Shengjuler D Fletcher SJ O'Neal MC Cai Y Chang JCJ Broadhurst DJ Klippsten S Sharp PP Wenzell NA Kuzuoglu-Ozturk D Wang HY Trenker R Young JM Cavero DA Hiatt J Roth TL Rathore U Subramanian A Noack J Hubert M Stroud RM Frankel AD Rosenberg OS Verba KA Agard DA Ott M Emerman M Jura N von Zastrow M Verdin E Ashworth A Schwartz O d'Enfert C Mukherjee S Jacobson M Malik HS Fujimori DG Ideker T Craik CS Floor SN Fraser JS Gross JD Sali A Roth BL Ruggero D Taunton J Kortemme T Beltrao P Vignuzzi M García-Sastre A Shokat KM Shoichet BK Krogan NJ 32838362 PubMed Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Med (N Y) 2021 Li J Guo M Tian X Wang X Yang X Wu P Liu C Xiao Z Qu Y Yin Y Wang C Zhang Y Zhu Z Liu Z Peng C Zhu T Liang Q respiratory system disease pathway PW:0001308 Pathway Ontology 32555321 PubMed Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH. Biochem Biophys Res Commun 1975 Schmoldt A Benthe HF Haberland G Jallon JM Risler Y Iwatsubo M