This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. Adapted from [KEGG](https://www.kegg.jp/pathway/hsa05010). cd0 a38 e30 de4 d8b bab ecf ff2 d2d ab3 ef0 ae0 d61 c1d f4f d78 d0a b1b ccf b50 fe2 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 e80 Added tentative pathway for now, includeing the role of vitamin D in calcium signalling (in depression). Mitochondrial respiratory chain complex I Mitochondrial respiratory chain complex II Mitochondrial respiratory chain complex III Mitochondrial respiratory chain complex IV Mitochondrial proton-transporting ATP synthase complex APP processing refers to the various ways in which the amyloid precursor protein (APP) is processed in the body. Expected to mean "G protein-coupled receptors (GPCRs)", which is a family of proteins Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 e98 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413 MOUSE:KG38 MOUSE MOUSE:KG38 MOUSE U13393 parentid=P35568; parentsymbol=IRS1; site=GLENGLNyIDLDLVK; position=tyr1179; sitegrpid=451288; ptm=p; direction=u parentid=P35568; parentsymbol=IRS1; site=EPKsPGEyVNIEFGS; position=tyr896; sitegrpid=447556; ptm=p; direction=u parentid=P35568; parentsymbol=IRS1; site=VPssRGDyMTMQMSC; position=tyr989; sitegrpid=451287; ptm=p; direction=u parentid=O75385; parentsymbol=ULK1; site=FDFPKtPssQNLLAL; position=ser638; sitegrpid=3176158; ptm=p; direction=d parentid=O75385; parentsymbol=ULK1; site=PVVFtVGsPPsGStP; position=ser758; sitegrpid=483139; ptm=p; direction=d parentid=Q14457; parentsymbol=BECN1; site=QPLkLDTsFkILDRV; position=ser30; sitegrpid=7446159; ptm=p; direction=u parentid=Q8NEB9; parentsymbol=PIK3C3; site=ESsPILTsFELVKVP; position=ser249; sitegrpid=35483209; ptm=p; direction=u parentid=Q9H0B6; parentsymbol=KLC2; site=LsDSRtLssssMDLs; position=ser608; sitegrpid=4693027; ptm=p; direction=d parentid=P35222; parentsymbol=CTNNB1; site=GIHsGATtTAPsLsG; position=thr41; sitegrpid=447583; ptm=p; direction=u parentid=P35222; parentsymbol=CTNNB1; site=QQQsyLDsGIHsGAT; position=ser33; sitegrpid=447487; ptm=p; direction=d parentid=P35222; parentsymbol=CTNNB1; site=yLDsGIHsGATtTAP; position=ser37; sitegrpid=447582; ptm=p; direction=u parentid=P45983; parentsymbol=MAPK8; site=tsFMMtPyVVtRYYR; position=tyr185; sitegrpid=447645; ptm=p; direction=u parentid=P45983; parentsymbol=MAPK8; site=AGtsFMMtPyVVtRY; position=thr183; sitegrpid=447643; ptm=p; direction=u parentid=P53779; parentsymbol=MAPK10; site=AGtsFMMtPyVVtRY; position=ser407; sitegrpid=448034; ptm=p; direction=u parentid=P45984; parentsymbol=MAPK9; site=ACtNFMMtPyVVtRY; position=thr183; sitegrpid=447649; ptm=p; direction=u parentid=P45984; parentsymbol=MAPK9; site=STEQtLAsDTDSSLD; position=ser407; sitegrpid=447648; ptm=p; direction=u parentid=P45984; parentsymbol=MAPK9; site=SSMSTEQtLAsDTDS; position=thr404; sitegrpid=447650; ptm=p; direction=u parentid=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u parentid=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u parentid=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGTRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u parentid=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u parentid=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u parentid=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u parentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u parentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u a19 a19 d7f eb0 17612493 PubMed MicroRNA targeting specificity in mammals: determinants beyond seed pairing. 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