This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. Adapted from [https://www.genome.jp/pathway/hsa05010 KEGG].
draft
cd0
a38
e30
de4
d8b
bab
ecf
ff2
d2d
ab3
ef0
ae0
d61
c1d
f4f
d78
d0a
b1b
ccf
b50
fe2
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
e80
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
e98
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
MOUSE:KG38 MOUSE
MOUSE:KG38 MOUSE
U13393
parentid=P35568; parentsymbol=IRS1; site=GLENGLNyIDLDLVK; position=tyr1179; sitegrpid=451288; ptm=p; direction=u
parentid=P35568; parentsymbol=IRS1; site=EPKsPGEyVNIEFGS; position=tyr896; sitegrpid=447556; ptm=p; direction=u
parentid=P35568; parentsymbol=IRS1; site=VPssRGDyMTMQMSC; position=tyr989; sitegrpid=451287; ptm=p; direction=u
parentid=O75385; parentsymbol=ULK1; site=FDFPKtPssQNLLAL; position=ser638; sitegrpid=3176158; ptm=p; direction=d
parentid=O75385; parentsymbol=ULK1; site=PVVFtVGsPPsGStP; position=ser758; sitegrpid=483139; ptm=p; direction=d
parentid=Q14457; parentsymbol=BECN1; site=QPLkLDTsFkILDRV; position=ser30; sitegrpid=7446159; ptm=p; direction=u
parentid=Q8NEB9; parentsymbol=PIK3C3; site=ESsPILTsFELVKVP; position=ser249; sitegrpid=35483209; ptm=p; direction=u
parentid=Q9H0B6; parentsymbol=KLC2; site=LsDSRtLssssMDLs; position=ser608; sitegrpid=4693027; ptm=p; direction=d
parentid=P35222; parentsymbol=CTNNB1; site=GIHsGATtTAPsLsG; position=thr41; sitegrpid=447583; ptm=p; direction=u
parentid=P35222; parentsymbol=CTNNB1; site=QQQsyLDsGIHsGAT; position=ser33; sitegrpid=447487; ptm=p; direction=d
parentid=P35222; parentsymbol=CTNNB1; site=yLDsGIHsGATtTAP; position=ser37; sitegrpid=447582; ptm=p; direction=u
parentid=P45983; parentsymbol=MAPK8; site=tsFMMtPyVVtRYYR; position=tyr185; sitegrpid=447645; ptm=p; direction=u
parentid=P45983; parentsymbol=MAPK8; site=AGtsFMMtPyVVtRY; position=thr183; sitegrpid=447643; ptm=p; direction=u
parentid=P53779; parentsymbol=MAPK10; site=AGtsFMMtPyVVtRY; position=ser407; sitegrpid=448034; ptm=p; direction=u
parentid=P45984; parentsymbol=MAPK9; site=ACtNFMMtPyVVtRY; position=thr183; sitegrpid=447649; ptm=p; direction=u
parentid=P45984; parentsymbol=MAPK9; site=STEQtLAsDTDSSLD; position=ser407; sitegrpid=447648; ptm=p; direction=u
parentid=P45984; parentsymbol=MAPK9; site=SSMSTEQtLAsDTDS; position=thr404; sitegrpid=447650; ptm=p; direction=u
parentid=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u
parentid=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u
parentid=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGTRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u
parentid=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u
parentid=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u
parentid=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u
parentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u
parentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u
a19
a19
d7f
eb0
20584986
PubMed
miR-375 inhibits differentiation of neurites by lowering HuD levels.
Mol Cell Biol
2010
Abdelmohsen K
Hutchison ER
Lee EK
Kuwano Y
Kim MM
Masuda K
Srikantan S
Subaran SS
Marasa BS
Mattson MP
Gorospe M
20048743
PubMed
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.
Lab Invest
2010
Zhou X
Ren Y
Moore L
Mei M
You Y
Xu P
Wang B
Wang G
Jia Z
Pu P
Zhang W
Kang C
29378302
PubMed
Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
Biochim Biophys Acta Mol Basis Dis
2018
Vargas LM
Cerpa W
Muñoz FJ
Zanlungo S
Alvarez AR
31655116
PubMed
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
Mol Cell Neurosci
2019
Sushma
Mondal AC
18829576
PubMed
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
Cancer Res
2008
Papagiannakopoulos T
Shapiro A
Kosik KS
31191253
PubMed
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
Front Cell Neurosci
2019
Palomer E
Buechler J
Salinas PC
23423488
PubMed
Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel.
Cancer Chemother Pharmacol
2013
Wu H
Huang M
Lu M
Zhu W
Shu Y
Cao P
Liu P
17055782
PubMed
Distinct destructive signal pathways of neuronal death in Alzheimer's disease.
Trends Mol Med
2006
Shen Y
He P
Zhong Z
McAllister C
Lindholm K
11484003
PubMed
Alzheimer's disease and Abeta toxicity: from top to bottom.
Nat Rev Neurosci
2001
Small DH
Mok SS
Bornstein JC
29890840
PubMed
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
Antioxid Redox Signal
2018
Popugaeva E
Pchitskaya E
Bezprozvanny I
18434550
PubMed
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Proc Natl Acad Sci U S A
2008
Hébert SS
Horré K
Nicolaï L
Papadopoulou AS
Mandemakers W
Silahtaroglu AN
Kauppinen S
Delacourte A
De Strooper B
27994051
PubMed
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
J Biol Chem
2017
Wasser CR
Herz J
15363492
PubMed
Induction of neuronal death by ER stress in Alzheimer's disease.
J Chem Neuroanat
2004
Katayama T
Imaizumi K
Manabe T
Hitomi J
Kudo T
Tohyama M
15232608
PubMed
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
J Clin Invest
2004
Dickson DW
22921398
PubMed
Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas.
Cell Rep
2012
Chan XH
Nama S
Gopal F
Rizk P
Ramasamy S
Sundaram G
Ow GS
Ivshina AV
Tanavde V
Haybaeck J
Kuznetsov V
Sampath P
16529745
PubMed
Tau phosphorylation and aggregation in Alzheimer's disease pathology.
FEBS Lett
2006
Avila J
15750290
PubMed
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
J Pharmacol Sci
2005
Takuma K
Yan SS
Stern DM
Yamada K
10830966
PubMed
Neurotoxicity induces cleavage of p35 to p25 by calpain.
Nature
2000
Lee MS
Kwon YT
Li M
Peng J
Friedlander RM
Tsai LH
Alzheimer disease pathway
PW:0000015
Pathway Ontology
15295589
PubMed
Pathways towards and away from Alzheimer's disease.
Nature
2004
Mattson MP
9848086
PubMed
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
Neurobiol Dis
1998
Hölscher C
disease pathway
PW:0000013
Pathway Ontology
18782350
PubMed
Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.
Aging Cell
2008
Reese LC
Zhang W
Dineley KT
Kayed R
Taglialatela G
17568632
PubMed
Presenilin-mediated signal transduction.
Physiol Behav
2007
Cowburn RF
Popescu BO
Ankarcrona M
Dehvari N
Cedazo-Minguez A
Alzheimers Dementia
DOID:10652
Disease
20486779
PubMed
MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1.
Stem Cells Dev
2011
Yang Z
Bian C
Zhou H
Huang S
Wang S
Liao L
Zhao RC
21131358
PubMed
Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets.
J Biol Chem
2011
Terao M
Fratelli M
Kurosaki M
Zanetti A
Guarnaccia V
Paroni G
Tsykin A
Lupi M
Gianni M
Goodall GJ
Garattini E
20417621
PubMed
MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region.
Biochem Biophys Res Commun
2010
Tian S
Huang S
Wu S
Guo W
Li J
He X
18675468
PubMed
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
Trends Neurosci
2008
Bezprozvanny I
Mattson MP
15864339
PubMed
The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.
J Clin Invest
2005
Gandy S
18035450
PubMed
Calcium dysregulation in Alzheimer's disease.
Neurochem Int
2008
Bojarski L
Herms J
Kuznicki J
17612493
PubMed
MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
Mol Cell
2007
Grimson A
Farh KK
Johnston WK
Garrett-Engele P
Lim LP
Bartel DP
15177383
PubMed
Alzheimer's disease pathogenesis and therapeutic interventions.
J Clin Neurosci
2004
Parihar MS
Hemnani T
16677790
PubMed
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
Exp Gerontol
2006
Hauptmann S
Keil U
Scherping I
Bonert A
Eckert A
Müller WE
28057414
PubMed
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
Trends Endocrinol Metab
2017
Lane-Donovan C
Herz J
27313835
PubMed
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage.
Oxid Med Cell Longev
2016
Piras S
Furfaro AL
Domenicotti C
Traverso N
Marinari UM
Pronzato MA
Nitti M
27807401
PubMed
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
Front Neurosci
2016
Vallée A
Lecarpentier Y
10527810
PubMed
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
Neurobiol Dis
1999
Ivins KJ
Thornton PL
Rohn TT
Cotman CW
24797360
PubMed
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology.
PLoS One
2014
Burgos K
Malenica I
Metpally R
Courtright A
Rakela B
Beach T
Shill H
Adler C
Sabbagh M
Villa S
Tembe W
Craig D
Van Keuren-Jensen K
30741722
PubMed
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
J Clin Invest
2019
Strickland MR
Holtzman DM
22285895
PubMed
MicroRNAs in Alzheimer's disease.
Neurobiol Dis
2012
Delay C
Mandemakers W
Hébert SS