Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [Wikipedia](http://www.wikipedia.org). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP534). Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway Gck is mainly active in liver Glucose-6-Phosphate (2-) D-Glucose-6-Phosphate (2-) open form phosphoglucose isomerase (PGI) fructose-6-phosphate (2-) open form glucose-6-phosphate isomerase efd gluconeogenesis pathway PW:0000641 Pathway Ontology glycolysis pathway PW:0000640 Pathway Ontology 22628558 PubMed A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012 Bricker DK Taylor EB Schell JC Orsak T Boutron A Chen YC Cox JE Cardon CM Van Vranken JG Dephoure N Redin C Boudina S Gygi SP Brivet M Thummel CS Rutter J citric acid cycle pathway PW:0000026 Pathway Ontology glycolysis/gluconeogenesis pathway PW:0000025 Pathway Ontology