Time- and exercise-dependent gene regulation in human skeletal muscle, http://genomebiology.com/2003/4/10/R61
Mouse genes regulated in the diurnal (inferred from human) and compared with mouse genes that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.e2093392 at94889 at95424 at92925 at104050 at104725 at97681 f at96029 at93833 s at99532 at101002 at103501 at104116 at95057 at101101 at104516 at99076 at97531 at100535 at102265 at95508 at97261 at100405 at97843 at93933 at93866 s at94481 at93829 at94835 f at94454 at99583 at95096 at96564 at160309 at97459 at93872 at162346 f at93527 at93104 at103888 at101091 at96269 atregulatory pathwayPW:0000004Pathway Ontologyskeletal muscle fiberCL:0008002Cell Ontology14519196PubMedTime- and exercise-dependent gene regulation in human skeletal muscle.Genome Biol2003Zambon ACMcDearmon ELSalomonis NVranizan KMJohansen KLAdey DTakahashi JSSchambelan MConklin BR