The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module.
Source: http://www.netpath.org/pathways?path_id=NetPath_4NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.http://cancer.cellmap.org; http://www.netpath.orgfd7epidermal growth factor/neuregulin signaling pathwayPW:0000170Pathway Ontology16007170PubMedControl of MAPK signalling: from complexity to what really matters.Oncogene2005Hornberg JJBinder BBruggeman FJSchoeberl BHeinrich RWesterhoff HV