The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10 NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway
 This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published. http://cancer.cellmap.org; http://www.netpath.org This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP47&oldid=20775 WP47(r20775)] with a 84% conversion rate. f8a ad8

Hedgehog signaling pathway PW:0000122 Pathway Ontology 3147217 PubMed Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 1988 Mohler J 15205520 PubMed The Hedgehog response network: sensors, switches, and routers. Science 2004 Lum L Beachy PA