The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP581 CPTAC Assay Portal] c55 b16 Not sure if complex consists of both A and B isoforms [thomas-081110] erythropoietin signaling pathway PW:0000987 Pathway Ontology oxidative phosphorylation pathway PW:0001059 Pathway Ontology 10334664 PubMed The molecular biology of erythropoietin. Nephrol Dial Transplant 1999 Lacombe C Mayeux P 9371269 PubMed The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol 1994 Zhu Y D'Andrea AD