We've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918 fd6 d98 fd6 fd6 cbd cbd p53-dependent G1/S DNA damage checkpoint pathway PW:0000304 Pathway Ontology 9918821 PubMed Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression. Biochem Biophys Res Commun 1998 Simbulan-Rosenthal CM Rosenthal DS Ding R Bhatia K Smulson ME 17000718 PubMed p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Toxicol Sci 2006 Nelson DM Bhaskaran V Foster WR Lehman-McKeeman LD 9565608 PubMed Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J Biol Chem 1998 Malanga M Pleschke JM Kleczkowska HE Althaus FR