Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.[1] It is also being studied for other types of cancer[1]. Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER)-positive (ER+) breast cancer in pre- and post-menopausal women[2]. Additionally, it is the most common hormone treatment for male breast cancer.
[1]: https://www.cancer.gov/about-cancer/treatment/drugs/tamoxifencitrate
[2]: Jordan, V. Craig. "A current view of tamoxifen for the treatment and prevention of breast cancer." British journal of pharmacology 110.2 (1993): 507-517.f3dfe9fe6c03a43ccd8242225PubMedFourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer.Br J Pharmacol1993Jordan VC19250197PubMedPotential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.Ann N Y Acad Sci2009Lazarus PBlevins-Primeau ASZheng YSun Destrogen-receptor positive breast cancerDOID:0060075Disease15135306PubMedQuaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.Biochem Pharmacol2004Kaku TOgura KNishiyama TOhnuma TMuro KHiratsuka A17186017PubMedChemoprevention of breast cancer with selective oestrogen-receptor modulators.Nat Rev Cancer2007Jordan VCxenobiotic metabolic pathwayPW:0001229Pathway Ontologybreast cancer pathwayPW:0000624Pathway Ontology16480962PubMedQuaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.Biochem Pharmacol2006Ogura KIshikawa YKaku TNishiyama TOhnuma TMuro KHiratsuka A17765940PubMedNew insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.Steroids2007Jordan VC