Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.[1] It is also being studied for other types of cancer[1]. Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER)-positive (ER+) breast cancer in pre- and post-menopausal women[2]. Additionally, it is the most common hormone treatment for male breast cancer. [1]: https://www.cancer.gov/about-cancer/treatment/drugs/tamoxifencitrate [2]: Jordan, V. Craig. "A current view of tamoxifen for the treatment and prevention of breast cancer." British journal of pharmacology 110.2 (1993): 507-517. f3d fe9 fe6 c03 a43 ccd 8242225 PubMed Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer. Br J Pharmacol 1993 Jordan VC 19250197 PubMed Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Ann N Y Acad Sci 2009 Lazarus P Blevins-Primeau AS Zheng Y Sun D estrogen-receptor positive breast cancer DOID:0060075 Disease 15135306 PubMed Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem Pharmacol 2004 Kaku T Ogura K Nishiyama T Ohnuma T Muro K Hiratsuka A 17186017 PubMed Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat Rev Cancer 2007 Jordan VC xenobiotic metabolic pathway PW:0001229 Pathway Ontology breast cancer pathway PW:0000624 Pathway Ontology 16480962 PubMed Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem Pharmacol 2006 Ogura K Ishikawa Y Kaku T Nishiyama T Ohnuma T Muro K Hiratsuka A 17765940 PubMed New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Steroids 2007 Jordan VC