Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC Assay Portal] cf5 b42 d73 estrogen signaling pathway PW:0000507 Pathway Ontology 16477006 PubMed IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A 2006 Song YJ Jen KY Soni V Kieff E Cahir-McFarland E 18089854 PubMed Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol 2008 Battaglia F Delfino S Merello E Puppo M Piva R Varesio L Bosco MC 16446357 PubMed TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem 2006 Uemura N Kajino T Sanjo H Sato S Akira S Matsumoto K Ninomiya-Tsuji J