Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC Assay Portal]cf5b42d73estrogen signaling pathwayPW:0000507Pathway Ontology16477006PubMedIL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.Proc Natl Acad Sci U S A2006Song YJJen KYSoni VKieff ECahir-McFarland E18089854PubMedHypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.J Leukoc Biol2008Battaglia FDelfino SMerello EPuppo MPiva RVaresio LBosco MC16446357PubMedTAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.J Biol Chem2006Uemura NKajino TSanjo HSato SAkira SMatsumoto KNinomiya-Tsuji J