This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009 [https://www.ncbi.nlm.nih.gov/pubmed/19715393]).f7be98d20da5d8fda5d87f30afccd1e17c13fe3c78e56bbde92e3de5fb49b49b49c088948389PubMedInfluence of using different sources of carotenoid data in epidemiologic studies.J Am Diet Assoc1996VandenLangenberg GMBrady WENebeling LCBlock GForman MBowen PEStacewicz-Sapuntzakis MMares-Perlman JA3019190PubMedInterrelationships among liposoluble vitamins in ruminants.Am J Vet Res1986Hidiroglou MWilliams CJ1416048PubMedSeparation and identification of carotenoids and their oxidation products in the extracts of human plasma.Anal Chem1992Khachik FBeecher GRGoli MBLusby WRSmith JC Jr15911617PubMedMetabolism and transactivation activity of 13,14-dihydroretinoic acid.J Biol Chem2005Moise ARKuksa VBlaner WSBaehr WPalczewski K9627692PubMedVitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.J Investig Dermatol Symp Proc1996Torma HRollman OBinderup LMichaelsson G12806616PubMedRelation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.Gastroenterology2003Ruhl CEEverhart JEretinol metabolic pathwayPW:0000141Pathway Ontology11585356PubMedVitamin A antagonizes calcium response to vitamin D in man.J Bone Miner Res2001Johansson SMelhus Hmetabolic pathway of cofactors and vitaminsPW:0000135Pathway Ontology1595584PubMedPlasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.Am J Clin Nutr1992Micozzi MSBrown EDEdwards BKBieri JGTaylor PRKhachik FBeecher GRSmith JC Jr18289917PubMedIdentification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig.Int J Biochem Cell Biol2008Sun YNg LLam WLo CKChan PTYuen YLWong PFTsang DSCheung WTLee SS19715393PubMedPathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.OMICS2009Waagmeester APezik PCoort STourniaire FEvelo CRebholz-Schuhmann D12937841PubMedPreliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.Neoplasma2003Czeczuga-Semeniuk EWolczynski SMarkiewicz W12401878PubMedGene expression regulation by retinoic acid.J Lipid Res2002Balmer JEBlomhoff R1444060PubMedAntioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.Ann N Y Acad Sci1992Sies HStahl WSundquist AR9453379PubMedVitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.Eur J Pediatr1997Huet FSemama DMaingueneau CCharavel ANivelon JL3372162PubMedCarotenoids in the human macula and whole retina.Invest Ophthalmol Vis Sci1988Handelman GJDratz EAReay CCvan Kuijk JG8017322PubMedSeasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.Am J Clin Nutr1994Olmedilla BGranado FBlanco IRojas-Hidalgo E2656356PubMedBiological actions of carotenoids.FASEB J1989Bendich AOlson JA10227052PubMedLycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.Nutr Cancer1999Amir HKaras MGiat JDanilenko MLevy RYermiahu TLevy JSharoni Y8878137PubMedAcute phase response and plasma carotenoid concentrations in older women: findings from the nun study.Nutrition1996Boosalis MGSnowdon DATully CLGross MDvitamin A and metabolites signaling pathwayPW:0001116Pathway OntologyenterocyteCL:0000584Cell Type15358783PubMedIdentification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.J Biol Chem2004Moise ARKuksa VImanishi YPalczewski K