This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining
Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.
A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1)
and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted
that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells.
Interactions and object/gene groups for the pathway exist for the majority of components.
ab3Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629canonical Wnt signaling pathwayPW:0000201Pathway OntologyPubMedKegg version of this pathwayhttp://www.genome.jp/kegg/pathway/hsa/hsa04310.html17372190PubMedWnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.Proc Natl Acad Sci U S A2007Miyabayashi TTeo JLYamamoto MMcMillan MNguyen CKahn M16894029PubMedRepression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.Mol Cell Biol2006Pereira LYi FMerrill BJ16881513PubMedManipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.Methods Mol Biol2006Sato NBrivanlou AH