Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]] This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP185&oldid=21067 WP185(r21067)] with a 87% conversion rate. b5c CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17 ILK; integrin-linked kinase [EC:2.7.1.-] PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 SOS1; son of sevenless homolog 1 (Drosophila) ZYX; zyxin RAP1A; RAP1A member of RAS oncogene family CRK; v-crk sarcoma virus CT10 oncogene homolog (avian CAPN5; calpain SEPP1; selenoprotein P plasma ROCK1; Rho-associated coiled-coil containing protein kinase VCL; vinculin GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene CAPN6; calpain 6 [EC:3.4.22.17] RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2) PXN; paxillin PAK6; p21(CDKN1A)-activated kinase MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-] BCAR1; breast cancer anti-estrogen resistance 1 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37] CAPN3; calpain 3 (p94) [EC:3.4.22.17] SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] DOCK1; dedicator of cyto-kinesis VAV3; vav 3 oncogene BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-] CAV2; caveolin 2 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-] CAPN11; calpain 11 [EC:3.4.22.17] CAPN10; calpain 10 [EC:3.4.22.17 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112] CSK; c-src tyrosine kinase [EC:2.7.1.112] CAV3; caveolin 3 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.- CAV1; caveolin 1 caveolae protein 22kD MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-] SHC1; SHC (Src homology 2 domain containing) transforming protein 1 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17] AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-] MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-] PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta) TNS; tensi CAPN7; calpain 7 [EC:3.4.22.17 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-] VAV2; vav 2 oncogene CDC42; cell division cycle 42 (GTP binding protein 25kD) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-] CAPNS1; calpain small subunit 1 [EC:3.4.22.17] PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-] MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-] MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-] SH3D5; SH3-domain protein 5 (ponsin RAP1B; RAP1B member of RAS oncogene family SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.- PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-] AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-] CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17] RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1) ROCK2; Rho-associated coiled-coil containing protein kinase GIT2; G protein-coupled receptor kinase-interactor 2 VASP; vasodilator-stimulated phosphoprotein PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-] AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-] GRB2; growth factor receptor-bound protein 2 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-] MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-] MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-] RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) TLN1; talin 1 SHC3; neuronal Sh PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112

integrin mediated signaling pathway PW:0000286 Pathway Ontology 16125000 PubMed Assembly and signaling of adhesion complexes. Curr Top Dev Biol 2005 Sepulveda JL Gkretsi V Wu C