Toll-like receptors (TLRs) are a critical part of the innate immune response, and are expressed on macrophages and dendritic cells. TLRs are pattern-recognition receptors, and recognize molecules derived from microbes. Once activated, TLRs result in activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules
TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NFkB and MAPK; and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NFkB and MAPK.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP75 CPTAC Assay Portal].
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Original kegg element: gene;71;hsa:23643
Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Original kegg element: gene;4;hsa:3654
Original kegg element: gene;69;hsa:941
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;75;hsa:7096
Original kegg element: gene;83;hsa:114609
Original kegg element: gene;78;hsa:54106
Original kegg element: gene;62;hsa:6772
Original kegg element: gene;5;hsa:51135
Original kegg element: gene;72;hsa:7100
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;14;hsa:4790
Original kegg element: gene;82;hsa:148022
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Original kegg element: gene;53;hsa:7189
Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Original kegg element: gene;58;hsa:6352
Original kegg element: gene;81;hsa:54472
Original kegg element: gene;45;hsa:3592 hsa:3593
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;16;hsa:7187
Original kegg element: gene;76;hsa:10333
Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;2;hsa:1147
Original kegg element: gene;52;hsa:29110
Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Original kegg element: gene;61;hsa:23118
Original kegg element: gene;45;hsa:3592 hsa:3593
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;3;hsa:7189
Original kegg element: gene;66;hsa:7124
Original kegg element: gene;29;hsa:958
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;87;hsa:841
Original kegg element: gene;46;hsa:114609
Original kegg element: gene;15;hsa:6696
Original kegg element: gene;44;hsa:6348
Original kegg element: gene;70;hsa:7097
Original kegg element: gene;25;hsa:3627
Original kegg element: gene;79;hsa:7099
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;39;hsa:51284 hsa:51311
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;54;hsa:9641
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;20;hsa:3665
Original kegg element: gene;63;hsa:5609 hsa:6416
Original kegg element: gene;51;hsa:3553
Original kegg element: gene;6;hsa:4615
Original kegg element: gene;41;hsa:3654
Original kegg element: gene;39;hsa:51284 hsa:51311
Original kegg element: gene;37;hsa:6885
Original kegg element: gene;80;hsa:353376
Original kegg element: gene;67;hsa:3661
Original kegg element: gene;57;hsa:3569
Original kegg element: gene;28;hsa:942
Original kegg element: gene;11;hsa:5594 hsa:5595
Original kegg element: gene;86;hsa:51135
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;84;hsa:929
Original kegg element: gene;1;hsa:3456
Original kegg element: gene;49;hsa:3454 hsa:3455
Original kegg element: gene;8;hsa:4615
Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Original kegg element: gene;17;hsa:8737
Original kegg element: gene;77;hsa:3929
Original kegg element: gene;7;hsa:4615
Original kegg element: gene;21;hsa:3663
Original kegg element: gene;59;hsa:10454
Original kegg element: gene;43;hsa:3576
Original kegg element: gene;11;hsa:5594 hsa:5595
Original kegg element: gene;12;hsa:5604 hsa:5605
Original kegg element: gene;56;hsa:8772
Original kegg element: gene;1;hsa:3456
Original kegg element: gene;12;hsa:5604 hsa:5605
Original kegg element: gene;49;hsa:3454 hsa:3455
Original kegg element: gene;9;hsa:7189
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;47;hsa:4615
Original kegg element: gene;13;hsa:1326
Original kegg element: gene;48;hsa:5879
Original kegg element: gene;74;hsa:7097
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;63;hsa:5609 hsa:6416
Original kegg element: gene;24;hsa:4283
Original kegg element: gene;73;hsa:7098
Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Original kegg element: gene;38;hsa:6351
Original kegg element: gene;35;hsa:2353 hsa:3725
Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Original kegg element: gene;23;hsa:6373
Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Original kegg element: gene;61;hsa:23118
parentid=Q14653; parentsymbol=IRF3; site=sHPLsLtsDQYKAYL; position=ser405; sitegrpid=449032; ptm=p; direction=u
parentid=P51617; parentsymbol=IRAK1; site=RtQTVRGtLAYLPEE; position=thr387; sitegrpid=447721; ptm=p; direction=u
parentid=P51617; parentsymbol=IRAK1; site=GSsPsQssMVARtQT; position=ser376; sitegrpid=449756; ptm=p; direction=u
parentid=Q14653; parentsymbol=IRF3; site=IsNsHPLsLtsDQYK; position=ser402; sitegrpid=449030; ptm=p; direction=u
parentid=Q14653; parentsymbol=IRF3; site=NtVDLHIsNsHPLsL; position=ser396; sitegrpid=449028; ptm=p; direction=u
parentid=Q92985; parentsymbol=IRF7; site=VssLDSSsLsLCLsS; position=ser477; sitegrpid=1276101; ptm=p; direction=u
parentid=Q14653; parentsymbol=IRF3; site=NsHPLsLtsDQYKAY; position=thr404; sitegrpid=449031; ptm=p; direction=u
parentid=Q14653; parentsymbol=IRF3; site=VDLHIsNsHPLsLts; position=ser398; sitegrpid=449029; ptm=p; direction=u
parentid=Q92985; parentsymbol=IRF7; site=sLDSSsLsLCLsSAN; position=ser479; sitegrpid=2868600; ptm=p; direction=u
parentid=O14920; parentsymbol=IKBKB; site=DQGsLCtsFVGTLQy; position=ser181; sitegrpid=447489; ptm=p; direction=u
parentid=P25963; parentsymbol=NFKBIA; site=LLDDRHDsGLDsMkD; position=ser32; sitegrpid=448203; ptm=p; direction=d
parentid=P25963; parentsymbol=NFKBIA; site=RHDsGLDsMkDEEyE; position=ser36; sitegrpid=448204; ptm=p; direction=d
parentid=P25963; parentsymbol=NFKBIA; site=LLDDRHDsGLDsMkD; position=ser32; sitegrpid=448203; ptm=p; direction=d
parentid=P25963; parentsymbol=NFKBIA; site=RHDsGLDsMkDEEyE; position=ser36; sitegrpid=448204; ptm=p; direction=d
parentid=P05412; parentsymbol=JUN; site=VGLLkLAsPELERLI; position=ser73; sitegrpid=447943; ptm=p; direction=u
parentid=P05412; parentsymbol=JUN; site=kNsDLLtsPDVGLLk; position=ser63; sitegrpid=447686; ptm=p; direction=u
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signaling pathway pertinent to immunity
PW:0000818
Pathway Ontology
Toll-like receptor signaling pathway
PW:0000814
Pathway Ontology
hsa04620
KEGG Pathway
KEGG Toll-like receptor signaling
https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa04620