ID Database Citation 1723621 Pubmed "Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. Schoorlemmer J, Kruijer W. Mech Dev. 1991 Dec;36(1–2):75–86. PubMed Europe PMC Scholia" 7590241 Pubmed "Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Yuan H, Corbi N, Basilico C, Dailey L. Genes Dev. 1995 Nov 1;9(21):2635–45. PubMed Europe PMC Scholia" 7973727 Pubmed "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Science. 1994 Nov 25;266(5189):1376–80. PubMed Europe PMC Scholia" 8289793 Pubmed "Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Schoorlemmer J, van Puijenbroek A, van Den Eijnden M, Jonk L, Pals C, Kruijer W. Mol Cell Biol. 1994 Feb;14(2):1122–36. PubMed Europe PMC Scholia" 9584197 Pubmed "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E. Mol Cell Biol. 1998 Jun;18(6):3572–9. PubMed Europe PMC Scholia" 9649508 Pubmed "Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Niwa H, Burdon T, Chambers I, Smith A. Genes Dev. 1998 Jul 1;12(13):2048–60. PubMed Europe PMC Scholia" 9649510 Pubmed "New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, et al. Genes Dev. 1998 Jul 1;12(13):2073–90. PubMed Europe PMC Scholia" 10383138 Pubmed "Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. Majewski M, Nieborowska-Skorska M, Salomoni P, Slupianek A, Reiss K, Trotta R, et al. Cancer Res. 1999 Jun 15;59(12):2815–9. PubMed Europe PMC Scholia" 10692469 Pubmed "Synergy of SF1 and RAR in activation of Oct-3/4 promoter. Barnea E, Bergman Y. J Biol Chem. 2000 Mar 3;275(9):6608–19. PubMed Europe PMC Scholia" 10747963 Pubmed "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. Kurooka H, Honjo T. J Biol Chem. 2000 Jun 2;275(22):17211–20. PubMed Europe PMC Scholia" 10749849 Pubmed "The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, et al. J Biol Chem. 2000 Jun 16;275(24):18391–8. PubMed Europe PMC Scholia" 11585818 Pubmed "A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. Satou A, Taira T, Iguchi-Ariga SM, Ariga H. J Biol Chem. 2001 Dec 7;276(49):46562–7. PubMed Europe PMC Scholia" 11702949 Pubmed "Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, et al. Dev Cell. 2001 Sep;1(3):377–87. PubMed Europe PMC Scholia" 11742412 Pubmed "Insulin signalling and the regulation of glucose and lipid metabolism. Saltiel AR, Kahn CR. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia" 12372629 Pubmed "Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation. Xie X, Chan RJ, Yoder MC. FEBS Lett. 2002 Oct 9;529(2–3):361–4. PubMed Europe PMC Scholia" 12655299 Pubmed "Degradation of chromosomal DNA during apoptosis. Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H. Cell Death Differ. 2003 Jan;10(1):108–16. PubMed Europe PMC Scholia" 12665572 Pubmed "Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, et al. Mol Cell Biol. 2003 Apr;23(8):2699–708. PubMed Europe PMC Scholia" 12774123 Pubmed "Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Takahashi K, Mitsui K, Yamanaka S. Nature. 2003 May 29;423(6939):541–5. PubMed Europe PMC Scholia" 15042697 Pubmed "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Adams IR, McLaren A. Dev Dyn. 2004 Apr;229(4):733–44. PubMed Europe PMC Scholia" 15047715 Pubmed "Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, et al. J Biol Chem. 2004 May 28;279(22):23495–503. PubMed Europe PMC Scholia" 15075392 Pubmed "BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Qi X, Li TG, Hao J, Hu J, Wang J, Simmons H, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6027–32. PubMed Europe PMC Scholia" 15328362 Pubmed "Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Paling NRD, Wheadon H, Bone HK, Welham MJ. J Biol Chem. 2004 Nov 12;279(46):48063–70. PubMed Europe PMC Scholia" 15501218 Pubmed "Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Rao M. Dev Biol. 2004 Nov 15;275(2):269–86. PubMed Europe PMC Scholia" 15557334 Pubmed "Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F. J Biol Chem. 2005 Feb 18;280(7):5307–17. PubMed Europe PMC Scholia" 15619621 Pubmed "p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, et al. Nat Cell Biol. 2005 Feb;7(2):165–71. PubMed Europe PMC Scholia" 15673569 Pubmed "LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Cartwright P, McLean C, Sheppard A, Rivett D, Jones K, Dalton S. Development. 2005 Mar;132(5):885–96. PubMed Europe PMC Scholia" 15713654 Pubmed "The C terminus of p53 family proteins is a cell fate determinant. Harms KL, Chen X. Mol Cell Biol. 2005 Mar;25(5):2014–30. PubMed Europe PMC Scholia" 15743839 Pubmed "Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Kuroda T, Tada M, Kubota H, Kimura H, Hatano S ya, Suemori H, et al. Mol Cell Biol. 2005 Mar;25(6):2475–85. PubMed Europe PMC Scholia" 15831456 Pubmed "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Gu P, Goodwin B, Chung ACK, Xu X, Wheeler DA, Price RR, et al. Mol Cell Biol. 2005 May;25(9):3492–505. PubMed Europe PMC Scholia" 15860457 Pubmed "Transcriptional regulation of nanog by OCT4 and SOX2. Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, et al. J Biol Chem. 2005 Jul 1;280(26):24731–7. PubMed Europe PMC Scholia" 15917470 Pubmed "Stimulation of Oct-4 activity by Ewing’s sarcoma protein. Lee J, Rhee BK, Bae GY, Han YM, Kim J. Stem Cells. 2005;23(6):738–51. PubMed Europe PMC Scholia" 15930108 Pubmed "The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Tapscott SJ. Development. 2005 Jun;132(12):2685–95. PubMed Europe PMC Scholia" 15988017 Pubmed "Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, et al. Mol Cell Biol. 2005 Jul;25(14):6031–46. PubMed Europe PMC Scholia" 16099994 Pubmed "Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells. Sekkaï D, Gruel G, Herry M, Moucadel V, Constantinescu SN, Albagli O, et al. Stem Cells. 2005;23(10):1634–42. PubMed Europe PMC Scholia" 16153702 Pubmed "Core transcriptional regulatory circuitry in human embryonic stem cells. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Cell. 2005 Sep 23;122(6):947–56. PubMed Europe PMC Scholia" 16227977 Pubmed "Regulatory networks in embryo-derived pluripotent stem cells. Boiani M, Schöler HR. Nat Rev Mol Cell Biol. 2005 Nov;6(11):872–84. PubMed Europe PMC Scholia" 16244670 Pubmed "The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Rowland BD, Bernards R, Peeper DS. Nat Cell Biol. 2005 Nov;7(11):1074–82. PubMed Europe PMC Scholia" 16246160 Pubmed "Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Takahashi K, Murakami M, Yamanaka S. Biochem Soc Trans. 2005 Dec;33(Pt 6):1522–5. PubMed Europe PMC Scholia" 16287840 Pubmed "Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, et al. Mol Cell Biol. 2005 Dec;25(23):10220–34. PubMed Europe PMC Scholia" 16293629 Pubmed "The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. Reinhold MI, Kapadia RM, Liao Z, Naski MC. J Biol Chem. 2006 Jan 20;281(3):1381–8. PubMed Europe PMC Scholia" 16325584 Pubmed "Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, et al. Cell. 2005 Dec 2;123(5):917–29. PubMed Europe PMC Scholia" 16330017 Pubmed "WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Hao J, Li TG, Qi X, Zhao DF, Zhao GQ. Dev Biol. 2006 Feb 1;290(1):81–91. PubMed Europe PMC Scholia" 16415856 Pubmed "G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, et al. Nat Cell Biol. 2006 Feb;8(2):188–94. PubMed Europe PMC Scholia" 16462733 Pubmed "The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B. Nat Cell Biol. 2006 Mar;8(3):285–92. PubMed Europe PMC Scholia" 16518401 Pubmed "The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, et al. Nat Genet. 2006 Apr;38(4):431–40. PubMed Europe PMC Scholia" 16541131 Pubmed "Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter. Wu DY, Yao Z. Cell Res. 2006 Mar;16(3):319–22. PubMed Europe PMC Scholia" 16570849 Pubmed "Molecular enzymology of mammalian DNA methyltransferases. Jeltsch A. Curr Top Microbiol Immunol. 2006;301:203–25. PubMed Europe PMC Scholia" 16631596 Pubmed "The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. Sato N, Kondo M, Arai K ichi. Biochem Biophys Res Commun. 2006 Jun 9;344(3):845–51. PubMed Europe PMC Scholia" 16714766 Pubmed "Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D. J Biol Chem. 2006 Aug 18;281(33):23319–25. PubMed Europe PMC Scholia" 16790473 Pubmed "The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, et al. Development. 2006 Aug;133(15):3005–13. PubMed Europe PMC Scholia" 16790525 Pubmed "A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. Pan G, Li J, Zhou Y, Zheng H, Pei D. FASEB J. 2006 Aug;20(10):1730–2. PubMed Europe PMC Scholia" 16801560 Pubmed "Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Suzuki A, Raya Á, Kawakami Y, Morita M, Matsui T, Nakashima K, et al. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10294–9. PubMed Europe PMC Scholia" 16840789 Pubmed "Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, et al. J Biol Chem. 2006 Aug 25;281(34):24090–4. PubMed Europe PMC Scholia" 16894029 Pubmed "Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Pereira L, Yi F, Merrill BJ. Mol Cell Biol. 2006 Oct;26(20):7479–91. PubMed Europe PMC Scholia" 16908534 Pubmed "The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Hamazaki T, Kehoe SM, Nakano T, Terada N. Mol Cell Biol. 2006 Oct;26(20):7539–49. PubMed Europe PMC Scholia" 16954384 Pubmed "Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, et al. Mol Cell Biol. 2006 Oct;26(20):7772–82. PubMed Europe PMC Scholia" 16980957 Pubmed "Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, et al. Nat Cell Biol. 2006 Oct;8(10):1114–23. PubMed Europe PMC Scholia" 16988490 Pubmed "Identification of Jmjd1a as a STAT3 downstream gene in mES cells. Ko SY, Kang HY, Lee HS, Han SY, Hong SH. Cell Struct Funct. 2006;31(2):53–62. PubMed Europe PMC Scholia" 16997917 Pubmed "Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. Choi Y, Rajkovic A. J Biol Chem. 2006 Nov 24;281(47):35747–56. PubMed Europe PMC Scholia" 17073552 Pubmed "Mechanisms controlling embryonic stem cell self-renewal and differentiation. Sun Y, Li H, Yang H, Rao MS, Zhan M. Crit Rev Eukaryot Gene Expr. 2006;16(3):211–31. PubMed Europe PMC Scholia" 17093407 Pubmed "A protein interaction network for pluripotency of embryonic stem cells. Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, et al. Nature. 2006 Nov 16;444(7117):364–8. PubMed Europe PMC Scholia" 17182901 Pubmed "Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, et al. J Cell Sci. 2007 Jan 1;120(Pt 1):55–65. PubMed Europe PMC Scholia" 17183653 Pubmed "Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. Matoba R, Niwa H, Masui S, Ohtsuka S, Carter MG, Sharov AA, et al. PLoS One. 2006 Dec 20;1(1):e26. PubMed Europe PMC Scholia" 17187077 Pubmed "SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN. Nat Struct Mol Biol. 2007 Jan;14(1):68–75. PubMed Europe PMC Scholia" 17196549 Pubmed "Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Takao Y, Yokota T, Koide H. Biochem Biophys Res Commun. 2007 Feb 16;353(3):699–705. PubMed Europe PMC Scholia" 17211451 Pubmed "Nanog and transcriptional networks in embryonic stem cell pluripotency. Pan G, Thomson JA. Cell Res. 2007 Jan;17(1):42–9. PubMed Europe PMC Scholia" 17215298 Pubmed "How is pluripotency determined and maintained? Niwa H. Development. 2007 Feb;134(4):635–46. PubMed Europe PMC Scholia" 17218270 Pubmed "Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Mol Cell. 2007 Jan 12;25(1):43–56. PubMed Europe PMC Scholia" 17267691 Pubmed "Zic3 is required for maintenance of pluripotency in embryonic stem cells. Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, et al. Mol Biol Cell. 2007 Apr;18(4):1348–58. PubMed Europe PMC Scholia" 17268471 Pubmed "Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, et al. Nature. 2007 Feb 8;445(7128):671–5. PubMed Europe PMC Scholia" 17289590 Pubmed "Balancing BMP signaling through integrated inputs into the Smad1 linker. Sapkota G, Alarcón C, Spagnoli FM, Brivanlou AH, Massagué J. Mol Cell. 2007 Feb 9;25(3):441–54. PubMed Europe PMC Scholia" 17344211 Pubmed "Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells. Wang ZX, Teh CHL, Kueh JLL, Lufkin T, Robson P, Stanton LW. J Biol Chem. 2007 Apr 27;282(17):12822–30. PubMed Europe PMC Scholia" 17360716 Pubmed "Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Kim JH, et al. J Biol Chem. 2007 May 4;282(18):13672–9. PubMed Europe PMC Scholia" 17372190 Pubmed "Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia" 17448993 Pubmed "Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, et al. Cell. 2007 Apr 20;129(2):345–57. PubMed Europe PMC Scholia" 17496161 Pubmed "Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. Zhang Z, Liao B, Xu M, Jin Y. FASEB J. 2007 Oct;21(12):3042–51. PubMed Europe PMC Scholia" 17515932 Pubmed "Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, et al. Nat Cell Biol. 2007 Jun;9(6):625–35. PubMed Europe PMC Scholia" 17579724 Pubmed "Oct4 targets regulatory nodes to modulate stem cell function. Campbell PA, Perez-Iratxeta C, Andrade-Navarro MA, Rudnicki MA. PLoS One. 2007 Jun 20;2(6):e553. PubMed Europe PMC Scholia" 17625255 Pubmed "Pluripotent stem cells and their niches. Lensch MW, Daheron L, Schlaeger TM. Stem Cell Rev. 2006;2(3):185–201. PubMed Europe PMC Scholia" 17628018 Pubmed "Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells. Wang ZX, Kueh JLL, Teh CHL, Rossbach M, Lim L, Li P, et al. Stem Cells. 2007 Sep;25(9):2173–82. PubMed Europe PMC Scholia" 17634527 Pubmed "WNT signaling pathway and stem cell signaling network. Katoh M, Katoh M. Clin Cancer Res. 2007 Jul 15;13(14):4042–5. PubMed Europe PMC Scholia" 17673620 Pubmed "UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE. Science. 2007 Sep 21;317(5845):1760–4. PubMed Europe PMC Scholia" 17713478 Pubmed "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, Cloos PAC, Christensen J, Pasini D, Rose S, Rappsilber J, et al. Nature. 2007 Oct 11;449(7163):731–4. PubMed Europe PMC Scholia" 17879059 Pubmed "The molecular mechanism of embryonic stem cell pluripotency and self-renewal. Liu Y, Ji L, Ten Y, Wang Y, Pei X. Sci China C Life Sci. 2007 Oct;50(5):619–23. PubMed Europe PMC Scholia" 17908689 Pubmed "Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C. J Biol Chem. 2007 Nov 23;282(47):33994–4002. PubMed Europe PMC Scholia" 17938196 Pubmed "Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, et al. Mol Cell Biol. 2007 Dec;27(24):8748–59. PubMed Europe PMC Scholia" 17938240 Pubmed "Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Loh YH, Zhang W, Chen X, George J, Ng HH. Genes Dev. 2007 Oct 15;21(20):2545–57. PubMed Europe PMC Scholia" 17940043 Pubmed "A gene regulatory network in mouse embryonic stem cells. Zhou Q, Chipperfield H, Melton DA, Wong WH. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16438–43. PubMed Europe PMC Scholia" 17989703 Pubmed "Small molecules in stem cell self-renewal and differentiation. Schugar RC, Robbins PD, Deasy BM. Gene Ther. 2008 Jan;15(2):126–35. PubMed Europe PMC Scholia" 17991485 Pubmed "PIAS proteins as repressors of Oct4 function. Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A. J Mol Biol. 2007 Dec 14;374(5):1200–12. PubMed Europe PMC Scholia" 18201968 Pubmed "STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, et al. J Biol Chem. 2008 Apr 11;283(15):9713–23. PubMed Europe PMC Scholia" 18220859 Pubmed "Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Okita K, Yamanaka S. Curr Stem Cell Res Ther. 2006 Jan;1(1):103–11. PubMed Europe PMC Scholia" 18223644 Pubmed "Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Torres J, Watt FM. Nat Cell Biol. 2008 Feb;10(2):194–201. PubMed Europe PMC Scholia" 18264089 Pubmed "A core Klf circuitry regulates self-renewal of embryonic stem cells. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, et al. Nat Cell Biol. 2008 Mar;10(3):353–60. PubMed Europe PMC Scholia" 18274628 Pubmed "Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation. Mullen EM, Gu P, Cooney AJ. PPAR Res. 2007;2007:61563. PubMed Europe PMC Scholia" 18295569 Pubmed "Capturing pluripotency. Silva J, Smith A. Cell. 2008 Feb 22;132(4):532–6. PubMed Europe PMC Scholia" 18295576 Pubmed "Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Jaenisch R, Young R. Cell. 2008 Feb 22;132(4):567–82. PubMed Europe PMC Scholia" 18311151 Pubmed "A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Benetti R, Gonzalo S, Jaco I, Muñoz P, Gonzalez S, Schoeftner S, et al. Nat Struct Mol Biol. 2008 Mar;15(3):268–79. PubMed Europe PMC Scholia" 18339675 Pubmed "Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Endoh M, Endo TA, Endoh T, Fujimura Y ichi, Ohara O, Toyoda T, et al. Development. 2008 Apr;135(8):1513–24. PubMed Europe PMC Scholia" 18347094 Pubmed "Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Genes Dev. 2008 Mar 15;22(6):746–55. PubMed Europe PMC Scholia" 18366076 Pubmed "Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A. J Cell Physiol. 2008 Sep;216(3):651–62. PubMed Europe PMC Scholia" 18436640 Pubmed "Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Wang J, Levasseur DN, Orkin SH. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6326–31. PubMed Europe PMC Scholia" 18447642 Pubmed "Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate. Foshay KM, Gallicano GI. Stem Cells Dev. 2008 Apr;17(2):269–78. PubMed Europe PMC Scholia" 18454139 Pubmed "Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, et al. Nat Cell Biol. 2008 Jun;10(6):731–9. PubMed Europe PMC Scholia" 18462695 Pubmed "A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Sampath P, Pritchard DK, Pabon L, Reinecke H, Schwartz SM, Morris DR, et al. Cell Stem Cell. 2008 May 8;2(5):448–60. PubMed Europe PMC Scholia" 18467660 Pubmed "T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, et al. Stem Cells. 2008 Aug;26(8):2019–31. PubMed Europe PMC Scholia" 18522852 Pubmed "Caspase activity mediates the differentiation of embryonic stem cells. Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, et al. Cell Stem Cell. 2008 Jun 5;2(6):595–601. PubMed Europe PMC Scholia" 18555785 Pubmed "Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Cell. 2008 Jun 13;133(6):1106–17. PubMed Europe PMC Scholia" 18562239 Pubmed "The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Ramos JW. Int J Biochem Cell Biol. 2008;40(12):2707–19. PubMed Europe PMC Scholia" 18575582 Pubmed "B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G, et al. PLoS One. 2008 Jun 25;3(6):e2478. PubMed Europe PMC Scholia" 18585351 Pubmed "Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z, et al. Cell. 2008 Jun 27;133(7):1162–74. PubMed Europe PMC Scholia" 18614019 Pubmed "An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Fazzio TG, Huff JT, Panning B. Cell. 2008 Jul 11;134(1):162–74. PubMed Europe PMC Scholia" 18627319 Pubmed "Prospective of Ras signaling in stem cells. Chakrabarty K, Heumann R. Biol Chem. 2008 Jul;389(7):791–8. PubMed Europe PMC Scholia" 18653541 Pubmed "Klf5 is involved in self-renewal of mouse embryonic stem cells. Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, et al. J Cell Sci. 2008 Aug 15;121(Pt 16):2629–34. PubMed Europe PMC Scholia" 18662995 Pubmed "Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. van den Berg DLC, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, et al. Mol Cell Biol. 2008 Oct;28(19):5986–95. PubMed Europe PMC Scholia" 18687992 Pubmed "Zfp143 regulates Nanog through modulation of Oct4 binding. Chen X, Fang F, Liou YC, Ng HH. Stem Cells. 2008 Nov;26(11):2759–67. PubMed Europe PMC Scholia" 18757296 Pubmed "The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes. Wang ZX, Teh CHL, Chan CMY, Chu C, Rossbach M, Kunarso G, et al. Stem Cells. 2008 Nov;26(11):2791–9. PubMed Europe PMC Scholia" 18792115 Pubmed "Pleiotropic function of FGF-4: its role in development and stem cells. Kosaka N, Sakamoto H, Terada M, Ochiya T. Dev Dyn. 2009 Feb;238(2):265–76. PubMed Europe PMC Scholia" 18802003 Pubmed "Molecular coupling of Xist regulation and pluripotency. Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, et al. Science. 2008 Sep 19;321(5896):1693–5. PubMed Europe PMC Scholia" 18923680 Pubmed "Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation. Sun Y, Li H, Liu Y, Mattson MP, Rao MS, Zhan M. PLoS One. 2008;3(10):e3406. PubMed Europe PMC Scholia" 18953337 Pubmed "De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Epsztejn-Litman S, Feldman N, Abu-Remaileh M, Shufaro Y, Gerson A, Ueda J, et al. Nat Struct Mol Biol. 2008 Nov;15(11):1176–83. PubMed Europe PMC Scholia" 18957414 Pubmed "Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. Zhang X, Zhang J, Wang T, Esteban MA, Pei D. J Biol Chem. 2008 Dec 19;283(51):35825–33. PubMed Europe PMC Scholia" 18983969 Pubmed "Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, et al. Cell Stem Cell. 2008 Nov 6;3(5):555–67. PubMed Europe PMC Scholia" 19030024 Pubmed "Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Liu X, Huang J, Chen T, Wang Y, Xin S, Li J, et al. Cell Res. 2008 Dec;18(12):1177–89. PubMed Europe PMC Scholia" 19036726 Pubmed "Role for Med12 in regulation of Nanog and Nanog target genes. Tutter AV, Kowalski MP, Baltus GA, Iourgenko V, Labow M, Li E, et al. J Biol Chem. 2009 Feb 6;284(6):3709–18. PubMed Europe PMC Scholia" 19060217 Pubmed "Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19756–61. PubMed Europe PMC Scholia" 19079543 Pubmed "Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. Kidder BL, Yang J, Palmer S. PLoS One. 2008;3(12):e3932. PubMed Europe PMC Scholia" 19117947 Pubmed "Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, et al. J Biol Chem. 2009 Mar 6;284(10):6043–7. PubMed Europe PMC Scholia" 19136965 Pubmed "Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Feng B, Jiang J, Kraus P, Ng JH, Heng JCD, Chan YS, et al. Nat Cell Biol. 2009 Feb;11(2):197–203. PubMed Europe PMC Scholia" 19150979 Pubmed "Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression. Zhong X, Jin Y. J Biol Chem. 2009 Apr 3;284(14):9168–75. PubMed Europe PMC Scholia" 19151334 Pubmed "Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4. Bard JD, Gelebart P, Amin HM, Young LC, Ma Y, Lai R. FASEB J. 2009 May;23(5):1405–14. PubMed Europe PMC Scholia" 19221599 Pubmed "Post-translational regulation of Oct4 transcriptional activity. Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J. PLoS One. 2009;4(2):e4467. PubMed Europe PMC Scholia" 19282476 Pubmed "Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3. Vallania F, Schiavone D, Dewilde S, Pupo E, Garbay S, Calogero R, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5117–22. PubMed Europe PMC Scholia" 19340312 Pubmed "Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R. PLoS One. 2009;4(4):e5034. PubMed Europe PMC Scholia" 19345177 Pubmed "A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, et al. Cell Stem Cell. 2009 May 8;4(5):403–15. PubMed Europe PMC Scholia" 19349578 Pubmed "Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, et al. J Cell Biol. 2009 Apr 6;185(1):27–34. PubMed Europe PMC Scholia" 19399180 Pubmed "BNP signaling is crucial for embryonic stem cell proliferation. Abdelalim EM, Tooyama I. PLoS One. 2009;4(4):e5341. PubMed Europe PMC Scholia" 19400741 Pubmed "Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Gao Y, Wang B, Xiao Z, Chen B, Han J, Wang X, et al. Stem Cells Dev. 2010 Jan;19(1):53–60. PubMed Europe PMC Scholia" 19427042 Pubmed "Regulatory circuits underlying pluripotency and reprogramming. Do JT, Schöler HR. Trends Pharmacol Sci. 2009 Jun;30(6):296–302. PubMed Europe PMC Scholia" 19427291 Pubmed "A small molecule primes embryonic stem cells for differentiation. Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, et al. Cell Stem Cell. 2009 May 8;4(5):416–26. PubMed Europe PMC Scholia" 19440552 Pubmed "Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. Lu J, Jeong HW, Kong N, Yang Y, Carroll J, Luo HR, et al. PLoS One. 2009;4(5):e5577. PubMed Europe PMC Scholia" 19489080 Pubmed "Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, et al. Stem Cells. 2009 Jun;27(6):1244–54. PubMed Europe PMC Scholia" 19506034 Pubmed "Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. Lee JL, Wang MJ, Chen JY. J Cell Biol. 2009 Jun 15;185(6):949–57. PubMed Europe PMC Scholia" 19528230 Pubmed "Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T, Nishiyama A, et al. Mol Cell Biol. 2009 Aug;29(16):4574–83. PubMed Europe PMC Scholia" 19531481 Pubmed "PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Gao F, Kwon SW, Zhao Y, Jin Y. J Biol Chem. 2009 Aug 14;284(33):22263–73. PubMed Europe PMC Scholia" 19536159 Pubmed "The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. Nature. 2009 Jul 2;460(7251):128–32. PubMed Europe PMC Scholia" 19542351 Pubmed "The transcriptional foundation of pluripotency. Chambers I, Tomlinson SR. Development. 2009 Jul;136(14):2311–22. PubMed Europe PMC Scholia" 19544422 Pubmed "CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, et al. Stem Cells. 2009 Nov;27(11):2637–45. PubMed Europe PMC Scholia" 19544440 Pubmed "Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, et al. Stem Cells. 2009 Aug;27(8):1760–71. PubMed Europe PMC Scholia" 19556538 Pubmed "Trim24 targets endogenous p53 for degradation. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, et al. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612–6. PubMed Europe PMC Scholia" 19564334 Pubmed "Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, et al. J Biol Chem. 2009 Aug 28;284(35):23405–14. PubMed Europe PMC Scholia" 19564890 Pubmed "Cross-regulation of the Nanog and Cdx2 promoters. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, et al. Cell Res. 2009 Sep;19(9):1052–61. PubMed Europe PMC Scholia" 19571879 Pubmed "Telomerase modulates Wnt signalling by association with target gene chromatin. Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, et al. Nature. 2009 Jul 2;460(7251):66–72. PubMed Europe PMC Scholia" 19571885 Pubmed "A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Niwa H, Ogawa K, Shimosato D, Adachi K. Nature. 2009 Jul 2;460(7251):118–22. PubMed Europe PMC Scholia" 19603040 Pubmed "Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington’s canal. Hemberger M, Dean W, Reik W. Nat Rev Mol Cell Biol. 2009 Aug;10(8):526–37. PubMed Europe PMC Scholia" 19650037 Pubmed "Lsh participates in DNA methylation and silencing of stem cell genes. Xi S, Geiman TM, Briones V, Guang Tao Y, Xu H, Muegge K. Stem Cells. 2009 Nov;27(11):2691–702. PubMed Europe PMC Scholia" 19668188 Pubmed "The Ink4/Arf locus is a barrier for iPS cell reprogramming. Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, et al. Nature. 2009 Aug 27;460(7259):1136–9. PubMed Europe PMC Scholia" 19740739 Pubmed "Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. Yu H bing, Kunarso G, Hong FH, Stanton LW. J Biol Chem. 2009 Nov 6;284(45):31327–35. PubMed Europe PMC Scholia" 19785992 Pubmed "The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation. Hashimoto Y, Myojin R, Katoh N, Ohtsu M, Tashiro F, Onoda F, et al. Biochem Biophys Res Commun. 2009 Dec 11;390(2):223–9. PubMed Europe PMC Scholia" 19798101 Pubmed "Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WEF, et al. EMBO Rep. 2009 Nov;10(11):1259–64. PubMed Europe PMC Scholia" 19811652 Pubmed "ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage. Yeap LS, Hayashi K, Surani MA. Epigenetics Chromatin. 2009 Oct 7;2(1):12. PubMed Europe PMC Scholia" 19816951 Pubmed "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, et al. Stem Cells. 2009 Dec;27(12):2969–78. PubMed Europe PMC Scholia" 19821493 Pubmed "RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, Senapati S, et al. Stem Cells. 2009 Dec;27(12):3001–11. PubMed Europe PMC Scholia" 19884257 Pubmed "Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, et al. Genes Dev. 2009 Nov 1;23(21):2507–20. PubMed Europe PMC Scholia" 19888462 Pubmed "Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation. Zhu D, Fang J, Li Y, Zhang J. PLoS One. 2009 Nov 3;4(11):e7684. PubMed Europe PMC Scholia" 19890980 Pubmed "A novel signaling by vitamin A/retinol promotes self renewal of mouse embryonic stem cells by activating PI3K/Akt signaling pathway via insulin-like growth factor-1 receptor. Chen L, Khillan JS. Stem Cells. 2010 Jan;28(1):57–63. PubMed Europe PMC Scholia" 19900215 Pubmed "Hypoxia-inducible factors in stem cells and cancer. Mazumdar J, Dondeti V, Simon MC. J Cell Mol Med. 2009;13(11–12):4319–28. PubMed Europe PMC Scholia" 19917253 Pubmed "Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, et al. Mol Cell. 2009 Nov 13;36(3):457–68. PubMed Europe PMC Scholia" 19926752 Pubmed "Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, et al. Genome Res. 2010 Jan;20(1):36–44. PubMed Europe PMC Scholia" 19933152 Pubmed "Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, et al. Genes Dev. 2009 Nov 15;23(22):2625–38. PubMed Europe PMC Scholia" 19951688 Pubmed "Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Hall J, Guo G, Wray J, Eyres I, Nichols J, Grotewold L, et al. Cell Stem Cell. 2009 Dec 4;5(6):597–609. PubMed Europe PMC Scholia" 19968627 Pubmed "Oct-4 controls cell-cycle progression of embryonic stem cells. Lee J, Go Y, Kang I, Han YM, Kim J. Biochem J. 2010 Feb 9;426(2):171–81. PubMed Europe PMC Scholia" 19997087 Pubmed "Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Liao B, Jin Y. Cell Res. 2010 Mar;20(3):332–44. PubMed Europe PMC Scholia" 20019792 Pubmed "Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells. Hong F, Fang F, He X, Cao X, Chipperfield H, Xie D, et al. PLoS Comput Biol. 2009 Dec;5(12):e1000607. PubMed Europe PMC Scholia" 20028735 Pubmed "The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, et al. Mol Cell Biol. 2010 Mar;30(5):1171–81. PubMed Europe PMC Scholia" 20071344 Pubmed "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. J Biol Chem. 2010 Mar 19;285(12):9180–9. PubMed Europe PMC Scholia" 20075857 Pubmed "JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Pasini D, Cloos PAC, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, et al. Nature. 2010 Mar 11;464(7286):306–10. PubMed Europe PMC Scholia" 20080709 Pubmed "Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, et al. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1402–7. PubMed Europe PMC Scholia" 20096661 Pubmed "The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Heng JCD, Feng B, Han J, Jiang J, Kraus P, Ng JH, et al. Cell Stem Cell. 2010 Feb 5;6(2):167–74. PubMed Europe PMC Scholia" 20110566 Pubmed "ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Wong LH, McGhie JD, Sim M, Anderson MA, Ahn S, Hannan RD, et al. Genome Res. 2010 Mar;20(3):351–60. PubMed Europe PMC Scholia" 20123894 Pubmed "Jarid2 and PRC2, partners in regulating gene expression. Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Genes Dev. 2010 Feb 15;24(4):368–80. PubMed Europe PMC Scholia" 20139965 Pubmed "Tbx3 improves the germ-line competency of induced pluripotent stem cells. Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, et al. Nature. 2010 Feb 25;463(7284):1096–100. PubMed Europe PMC Scholia" 20144788 Pubmed "Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, et al. Cell Stem Cell. 2010 Feb 5;6(2):153–66. PubMed Europe PMC Scholia" 20160104 Pubmed "Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. Larsen BD, Rampalli S, Burns LE, Brunette S, Dilworth FJ, Megeney LA. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4230–5. PubMed Europe PMC Scholia" 20305087 Pubmed "A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, et al. Mol Cell Proteomics. 2010 May;9(5):811–23. PubMed Europe PMC Scholia" 20362542 Pubmed "An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, et al. Cell Stem Cell. 2010 Apr 2;6(4):382–95. PubMed Europe PMC Scholia" 20505821 Pubmed "A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. Yang J, Gao C, Chai L, Ma Y. PLoS One. 2010 May 21;5(5):e10766. PubMed Europe PMC Scholia" 20506506 Pubmed "OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells. Addis RC, Prasad MK, Yochem RL, Zhan X, Sheets TP, Axelman J, et al. J Cell Biochem. 2010 Oct 1;111(2):391–401. PubMed Europe PMC Scholia" 20508149 Pubmed "TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner. Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, et al. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10926–31. PubMed Europe PMC Scholia" 20542030 Pubmed "Regulation of p53 in embryonic stem cells. Solozobova V, Blattner C. Exp Cell Res. 2010 Sep 10;316(15):2434–46. PubMed Europe PMC Scholia" 20622153 Pubmed "Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Moretto-Zita M, Jin H, Shen Z, Zhao T, Briggs SP, Xu Y. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13312–7. PubMed Europe PMC Scholia" 20639862 Pubmed "Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Nature. 2010 Aug 26;466(7310):1129–33. PubMed Europe PMC Scholia" 20875108 Pubmed "Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state. Parisi S, Cozzuto L, Tarantino C, Passaro F, Ciriello S, Aloia L, et al. BMC Biol. 2010 Sep 27;8:128. PubMed Europe PMC Scholia" 20937355 Pubmed "LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells. Kelly VR, Hammer GD. Mol Cell Endocrinol. 2011 Jan 30;332(1–2):116–24. PubMed Europe PMC Scholia" 20943815 Pubmed "Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD. Mol Endocrinol. 2010 Dec;24(12):2281–91. PubMed Europe PMC Scholia"