Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI Deoxyuridine monophosphate Metabolite pubchem.compound:65063 wikidata:Q2741362 chebi:17622;chebi:17622 inchikey:JSRLJPSBLDHEIO-SHYZEUOFSA-N Deoxythymidine monophosphate Metabolite pubchem.compound:9700 wikidata:Q23905769 chebi:17013;chebi:17013 inchikey:GYOZYWVXFNDGLU-XLPZGREQSA-N Tetrahydrofolate Metabolite cas:135-16-0 wikidata:Q53668656 chebi:20506;chebi:15635;chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N 5-Methyl Tetrahydrofolate Metabolite cas:134-35-0 wikidata:Q27290485 chebi:15641;chebi:15641 inchikey:ZNOVTXRBGFNYRX-ZGTCLIOFSA-N;inchikey:ZNOVTXRBGFNYRX-ABLWVSNPSA-N Alcohol Metabolite pubchem.compound:702 wikidata:Q153 chebi:16236;chebi:16236 inchikey:LFQSCWFLJHTTHZ-UHFFFAOYSA-N Betaine Metabolite cas:107-43-7 wikidata:Q10860583 chebi:17750;chebi:17750 inchikey:KWIUHFFTVRNATP-UHFFFAOYSA-N glycine Metabolite hmdb:HMDB0000123 chebi:15428;chebi:15428 inchikey:DHMQDGOQFOQNFH-UHFFFAOYSA-N 5-Formyl Tetrahydrofolate Metabolite cas:135-16-0 wikidata:Q53668656 chebi:20506;chebi:15635;chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N Zn Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N RiboflavinVitamin B2 Metabolite hmdb:HMDB0000244 chebi:17015;chebi:17015 inchikey:AUNGANRZJHBGPY-SCRDCRAPSA-N 10-Formyl Tetrahydrofolate Metabolite cas:2800-34-2 wikidata:Q47459238 chebi:15637;chebi:15637 inchikey:AUFGTPPARQZWDO-YUZLPWPTSA-N 5,10-Methenyl Tetrahydrofolate Metabolite cas:7444-29-3 wikidata:Q2823228 chebi:15636;chebi:15636;chebi:15638;chebi:15638 inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-N;inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-O Choline Metabolite cas:62-49-7 wikidata:Q193166 chebi:15354;chebi:15354 inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N 5-Formimino Tetrahydrofolate Metabolite cas:135-16-0 wikidata:Q53668656 chebi:20506;chebi:15635;chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N Folate Metabolite cas:59-30-3 wikidata:Q127060 chebi:27470;chebi:27470 inchikey:OVBPIULPVIDEAO-LBPRGKRZSA-N DihydrofolateVitamin B9 Metabolite cas:4033-27-6 wikidata:Q192367 chebi:15633;chebi:15633 inchikey:OZRNSSUDZOLUSN-LBPRGKRZSA-N 5,10-Methylene Tetrahydrofolate Metabolite chebi:12071 wikidata:Q27108922 chebi:12071;chebi:12071 inchikey:QYNUQALWYRSVHF-ABLWVSNPSA-L Methionine Metabolite cas:63-68-3 wikidata:Q106345486;wikidata:Q22124685 chebi:16643;chebi:57844;chebi:16643;chebi:57844 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N S-adenosylhomocysteine Metabolite cas:979-92-0 wikidata:Q106345616;wikidata:Q307434 chebi:16680;chebi:16680;chebi:57856;chebi:57856 inchikey:ZJUKTBDSGOFHSH-WFMPWKQPSA-N S-Adenosylmethionine Metabolite cas:29908-03-0 wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N Cobalamin Metabolite hmdb:HMDB0002174 chebi:28911;chebi:28911 inchikey:NSLAUEAQDBERRV-DSRCUDDDSA-L serine Metabolite pubchem.compound:617 wikidata:Q26997410 chebi:17822;chebi:17822 inchikey:MTCFGRXMJLQNBG-UHFFFAOYSA-N MethylcobalaminB12 Metabolite hmdb:HMDB0002274 chebi:28115;chebi:28115 inchikey:JEWJRMKHSMTXPP-WZHZPDAFSA-L Homocystine Metabolite chebi:17485 wikidata:Q58879461 chebi:17485;chebi:17485 inchikey:ZTVZLYBCZNMWCF-UHFFFAOYSA-N Pyridoxal 5'-phosphateVitamin B6 Metabolite hmdb:HMDB0001491 chebi:18405;chebi:18405 inchikey:NGVDGCNFYWLIFO-UHFFFAOYSA-N Homocysteine Metabolite hmdb:HMDB0000742 chebi:17588;chebi:17588 inchikey:FFFHZYDWPBMWHY-VKHMYHEASA-N Polyglutamate Metabolite cas:25513-46-6 wikidata:Q26995368 chebi:53374;chebi:53374 MAT1A GeneProduct ncbigene:4143 KEGG Database Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000151224 ncbigene:4143 hgnc.symbol:MAT1A uniprot:Q00266;uniprot:B1ANE6 BHMT GeneProduct ncbigene:635 ensembl:ENSG00000145692 ncbigene:635 hgnc.symbol:BHMT uniprot:Q93088;uniprot:E5RJH0;uniprot:V9HWA4 GRX1 GeneProduct ncbigene:2745 ensembl:ENSG00000173221 ncbigene:2745 hgnc.symbol:GLRX uniprot:A0A024RAM2;uniprot:P35754 MTHFS GeneProduct ncbigene:10588 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000136371 ncbigene:10588 hgnc.symbol:MTHFS uniprot:H3BMB9;uniprot:A0A0U1RQM3;uniprot:H3BN04;uniprot:P49914 DHFR GeneProduct ncbigene:1719 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 MTHFD2 GeneProduct ncbigene:10797 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000065911 ncbigene:10797 hgnc.symbol:MTHFD2 uniprot:F8WF89;uniprot:A0A7I2V2U6;uniprot:P13995;uniprot:B9A062;uniprot:F8WF06;uniprot:B8ZZU9;uniprot:A0A7I2V482;uniprot:A0A7I2V2G4;uniprot:A0A7I2V3T1;uniprot:A0A7I2YQD4 MTHFD1 GeneProduct ncbigene:4522 ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 MTHFD1L GeneProduct ncbigene:25902 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000120254 ncbigene:25902 hgnc.symbol:MTHFD1L uniprot:A0A087WVM4;uniprot:Q4VXV2;uniprot:Q5JYA8;uniprot:B7ZM99;uniprot:Q4VXM0;uniprot:Q4VXM1;uniprot:H0Y327;uniprot:Q5JYA3;uniprot:Q6UB35 FOLH1 GeneProduct ncbigene:2346 ensembl:ENSG00000086205 ncbigene:2346 hgnc.symbol:FOLH1 uniprot:E9PMK6;uniprot:Q04609;uniprot:E9PLV0;uniprot:E9PI29;uniprot:E9PKM3 MTFMT GeneProduct ncbigene:123263 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000103707 ncbigene:123263 hgnc.symbol:MTFMT uniprot:Q96DP5;uniprot:H3BTN9 DNMT1 GeneProduct ncbigene:1786 ensembl:ENSG00000130816 ncbigene:1786 hgnc.symbol:DNMT1 uniprot:A0A7I2V5D0;uniprot:P26358;uniprot:K7EKC3;uniprot:K7ELB1;uniprot:A0A7I2V3F8;uniprot:A0A7I2V5F6;uniprot:A0A7I2YQA8;uniprot:A0A7I2V490;uniprot:A0A7I2YQQ0;uniprot:K7ERQ1;uniprot:K7ENQ6;uniprot:K7EMU8;uniprot:K7EP77;uniprot:K7EJL0;uniprot:K7ER10;uniprot:K7ENW7;uniprot:A0A7I2V311;uniprot:A0A7I2V5F1;uniprot:K7EIZ6;uniprot:A0A7I2V2G5 MTHFD1 GeneProduct ncbigene:4522 ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 CHDH GeneProduct uniprot:Q8NE62 ensembl:ENSG00000016391 ncbigene:55349 hgnc.symbol:CHDH uniprot:C9J7D8;uniprot:C9JYW4;uniprot:Q8NE62 MTR GeneProduct ncbigene:4548 ensembl:ENSG00000116984 ncbigene:4548 hgnc.symbol:MTR uniprot:A0A6Q8PGK3;uniprot:A0A7P0TAV2;uniprot:A0A7P0T9G7;uniprot:Q99707;uniprot:A0A494C1A2;uniprot:A0A7P0T956;uniprot:A0A7P0TA06;uniprot:A0A7P0TAJ0;uniprot:A0A494C064;uniprot:B1ANE3 MTHFR GeneProduct ncbigene:4524 ensembl:ENSG00000177000 ncbigene:4524 hgnc.symbol:MTHFR uniprot:A0A286YF17;uniprot:Q5SNW5;uniprot:P42898;uniprot:Q5SNW7;uniprot:F8W9T8;uniprot:A0A286YFD0;uniprot:A0A286YF47;uniprot:A0A1B0GXD9;uniprot:L7P8G6 MTHFD1L GeneProduct ncbigene:25902 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000120254 ncbigene:25902 hgnc.symbol:MTHFD1L uniprot:A0A087WVM4;uniprot:Q4VXV2;uniprot:Q5JYA8;uniprot:B7ZM99;uniprot:Q4VXM0;uniprot:Q4VXM1;uniprot:H0Y327;uniprot:Q5JYA3;uniprot:Q6UB35 FTCD GeneProduct ncbigene:10841 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000160282 ncbigene:10841 hgnc.symbol:FTCD uniprot:O95954;uniprot:H7C315;uniprot:B7WPK3;uniprot:A0A804HKA5;uniprot:Q49AR5 DNMT3b GeneProduct ncbigene:1789 KEGG database: Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000088305 ncbigene:1789 hgnc.symbol:DNMT3B uniprot:B4DSJ7;uniprot:Q9UBC3;uniprot:A0A2Z2CIT2;uniprot:Q2PJS8 KIAA0828 GeneProduct ncbigene:23382 KEGG Database Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000158467 ncbigene:23382 hgnc.symbol:AHCYL2 uniprot:Q96HN2;uniprot:C9K0S0;uniprot:H0Y8B3;uniprot:C9JZV7 ALDH1L1 GeneProduct ncbigene:10840 ensembl:ENSG00000144908 ncbigene:10840 hgnc.symbol:ALDH1L1 uniprot:O75891;uniprot:C9IZ36;uniprot:F2Z324;uniprot:C9JY00;uniprot:D6RFJ7;uniprot:A0A0S2Z586;uniprot:C9JYZ6;uniprot:F8WC34 AMT GeneProduct ncbigene:275 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000145020 ncbigene:275 hgnc.symbol:AMT uniprot:A0A1B0GTM2;uniprot:A0A1B0GUU7;uniprot:A0A1B0GTV8;uniprot:A0A1B0GU55;uniprot:A0A1B0GVD0;uniprot:A0A1B0GV07;uniprot:A0A1B0GVP5;uniprot:C9JXJ4;uniprot:A0A1B0GTB6;uniprot:A0A1B0GWC4;uniprot:P48728;uniprot:A0A1B0GUK9;uniprot:A0A024R2U7;uniprot:B3KTU4;uniprot:H0Y695;uniprot:A0A1B0GTA8;uniprot:F8WF62 MTRR GeneProduct ncbigene:4552 ensembl:ENSG00000124275 ncbigene:4552 hgnc.symbol:MTRR uniprot:D6RAY3;uniprot:D6RGC7;uniprot:H0Y8S9;uniprot:D6RAZ2;uniprot:H0Y9D5;uniprot:D6RIS8;uniprot:Q9UBK8;uniprot:H0Y963;uniprot:A0A3P9MRF3;uniprot:H0Y9Q0;uniprot:D6RF21 MAT2B GeneProduct ncbigene:27430 KEGG Database Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000038274 ncbigene:27430 hgnc.symbol:MAT2B uniprot:A0A140VJP2;uniprot:Q9NZL9;uniprot:E5RJR3;uniprot:H7C0X7 FTCD GeneProduct ncbigene:10841 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000160282 ncbigene:10841 hgnc.symbol:FTCD uniprot:O95954;uniprot:H7C315;uniprot:B7WPK3;uniprot:A0A804HKA5;uniprot:Q49AR5 SHMT1 GeneProduct ncbigene:6470 ensembl:ENSG00000176974 ncbigene:6470 hgnc.symbol:SHMT1 uniprot:J3KRZ5;uniprot:J3KRK5;uniprot:P34896 AMT GeneProduct ncbigene:275 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000145020 ncbigene:275 hgnc.symbol:AMT uniprot:A0A1B0GTM2;uniprot:A0A1B0GUU7;uniprot:A0A1B0GTV8;uniprot:A0A1B0GU55;uniprot:A0A1B0GVD0;uniprot:A0A1B0GV07;uniprot:A0A1B0GVP5;uniprot:C9JXJ4;uniprot:A0A1B0GTB6;uniprot:A0A1B0GWC4;uniprot:P48728;uniprot:A0A1B0GUK9;uniprot:A0A024R2U7;uniprot:B3KTU4;uniprot:H0Y695;uniprot:A0A1B0GTA8;uniprot:F8WF62 TYMS GeneProduct ncbigene:7298 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000176890 ncbigene:7298 hgnc.symbol:TYMS uniprot:P04818;uniprot:Q53Y97 MTHFD1 GeneProduct ncbigene:4522 ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 GART GeneProduct ncbigene:2618 ensembl:ENSG00000159131 ncbigene:2618 hgnc.symbol:GART uniprot:C9JKQ7;uniprot:C9JTV6;uniprot:F8WD69;uniprot:H7C366;uniprot:C9JBJ1;uniprot:P22102;uniprot:C9JZG2 SHMT2 GeneProduct ncbigene:6472 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000182199 ncbigene:6472 hgnc.symbol:SHMT2 uniprot:G3V4X0;uniprot:H0YIZ0;uniprot:G3V2W0;uniprot:G3V2Y4;uniprot:G3V4T0;uniprot:G3V241;uniprot:G3V3Y8;uniprot:G3V4W5;uniprot:A0A024RB99;uniprot:G3V540;uniprot:G3V3C6;uniprot:G3V2Y1;uniprot:V9HW06;uniprot:G3V2D2;uniprot:G3V2E4;uniprot:P34897;uniprot:G3V5L0 MTHFD1L GeneProduct ncbigene:25902 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000120254 ncbigene:25902 hgnc.symbol:MTHFD1L uniprot:A0A087WVM4;uniprot:Q4VXV2;uniprot:Q5JYA8;uniprot:B7ZM99;uniprot:Q4VXM0;uniprot:Q4VXM1;uniprot:H0Y327;uniprot:Q5JYA3;uniprot:Q6UB35 DNMT3a GeneProduct ncbigene:1788 KEGG Database Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000119772 ncbigene:1788 hgnc.symbol:DNMT3A uniprot:Q9Y6K1;uniprot:F8WE91;uniprot:A0A0C4DG02 ATIC GeneProduct ncbigene:471 ensembl:ENSG00000138363 ncbigene:471 hgnc.symbol:ATIC uniprot:C9JLK0;uniprot:F2Z3E8;uniprot:V9HWH7;uniprot:F8WEF0;uniprot:P31939;uniprot:H7C1S2 MTHFD2 GeneProduct ncbigene:10797 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000065911 ncbigene:10797 hgnc.symbol:MTHFD2 uniprot:F8WF89;uniprot:A0A7I2V2U6;uniprot:P13995;uniprot:B9A062;uniprot:F8WF06;uniprot:B8ZZU9;uniprot:A0A7I2V482;uniprot:A0A7I2V2G4;uniprot:A0A7I2V3T1;uniprot:A0A7I2YQD4 AHCY GeneProduct ncbigene:191 KEGG Database Methionine metabolism - Homo sapiens (human) ensembl:ENSG00000101444 ncbigene:191 hgnc.symbol:AHCY uniprot:A0A384MTQ3;uniprot:P23526 TCN II GeneProduct ncbigene:6948 ensembl:ENSG00000185339 ncbigene:6948 hgnc.symbol:TCN2 uniprot:B5MBX2;uniprot:P20062;uniprot:F8WE86 GART GeneProduct ncbigene:2618 ensembl:ENSG00000159131 ncbigene:2618 hgnc.symbol:GART uniprot:C9JKQ7;uniprot:C9JTV6;uniprot:F8WD69;uniprot:H7C366;uniprot:C9JBJ1;uniprot:P22102;uniprot:C9JZG2 DHFR GeneProduct ncbigene:1719 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 DHFR GeneProduct ncbigene:1719 KEGG database: One carbon pool by folate - Homo sapiens (human) ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374