Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI DNA GeneProduct wikidata:Q7430 wikidata:Q7430 chebi:16991;chebi:16991 MAML1 GeneProduct ensembl:ENSG00000161021 ensembl:ENSG00000161021 ncbigene:9794 hgnc.symbol:MAML1 uniprot:Q92585 PSEN2 GeneProduct ensembl:ENSG00000143801 ensembl:ENSG00000143801 ncbigene:5664 hgnc.symbol:PSEN2 uniprot:E5RHT1;uniprot:E5RFW4;uniprot:E5RG63;uniprot:B1AP22;uniprot:E5RJM5;uniprot:P49810 APH1B GeneProduct ensembl:ENSG00000138613 ensembl:ENSG00000138613 ncbigene:83464 hgnc.symbol:APH1B uniprot:Q4R1J8;uniprot:H0YKZ9;uniprot:H0YM95;uniprot:H0YLT0;uniprot:Q8WW43 RBPSUHL GeneProduct ensembl:ENSG00000124232 ensembl:ENSG00000124232 ncbigene:11317 hgnc.symbol:RBPJL uniprot:A0A087X185;uniprot:Q5QPV1;uniprot:Q9UBG7 DVL3 GeneProduct ensembl:ENSG00000161202 ensembl:ENSG00000161202 ncbigene:1857 hgnc.symbol:DVL3 uniprot:A0A3B3ITC6;uniprot:Q92997;uniprot:F8WCF1;uniprot:A0A3B3ISG4 DTX3 GeneProduct ensembl:ENSG00000178498 ensembl:ENSG00000178498 ncbigene:196403 hgnc.symbol:DTX3 uniprot:A0A024RB96;uniprot:A0A0C4DGI8;uniprot:H0YHF9;uniprot:Q8N9I9;uniprot:F8VUZ4;uniprot:A0A1Y8EH36;uniprot:F8VV96 DLL3 GeneProduct ensembl:ENSG00000090932 ensembl:ENSG00000090932 ncbigene:10683 hgnc.symbol:DLL3 uniprot:M0R177;uniprot:Q9NYJ7 JAG2 GeneProduct ensembl:ENSG00000184916 ensembl:ENSG00000184916 ncbigene:3714 hgnc.symbol:JAG2 uniprot:Q9Y219 HDAC1 GeneProduct ensembl:ENSG00000116478 ensembl:ENSG00000116478 ncbigene:3065 hgnc.symbol:HDAC1 uniprot:Q13547;uniprot:Q6IT96;uniprot:Q5TEE2 JAG1 GeneProduct ensembl:ENSG00000101384 ensembl:ENSG00000101384 ncbigene:182 hgnc.symbol:JAG1 uniprot:P78504;uniprot:A0A087WXH5;uniprot:A0A087X1E8 DTX2 GeneProduct ensembl:ENSG00000091073 ensembl:ENSG00000091073 ncbigene:113878 hgnc.symbol:DTX2 uniprot:C9JEH4;uniprot:C9JII1;uniprot:C9JY61;uniprot:H7C3B8;uniprot:C9IYX1;uniprot:C9JS11;uniprot:C9JLU8;uniprot:E7ET89;uniprot:C9JF39;uniprot:C9JVC8;uniprot:Q86UW9 NUMB GeneProduct ensembl:ENSG00000133961 ensembl:ENSG00000133961 ncbigene:8650 hgnc.symbol:NUMB uniprot:G3V3M5;uniprot:A0A024R681;uniprot:G3V3R1;uniprot:A0A024R684;uniprot:G3V3Z8;uniprot:G3V433;uniprot:A0A024R6F4;uniprot:A0A024R6C4;uniprot:G3V4S6;uniprot:P49757 LFNG GeneProduct ensembl:ENSG00000106003 ensembl:ENSG00000106003 ncbigene:3955 hgnc.symbol:LFNG uniprot:Q8NES3;uniprot:A0A087X191 NCOR2 GeneProduct ensembl:ENSG00000196498 ensembl:ENSG00000196498 ncbigene:9612 hgnc.symbol:NCOR2 uniprot:C9JNV9;uniprot:C9J0Q5;uniprot:Q9Y618;uniprot:H7BZU2;uniprot:C9J330;uniprot:H7C2R5;uniprot:C9J7T7;uniprot:H7C0P3;uniprot:H7C184;uniprot:H7C1Y3;uniprot:C9JE98;uniprot:C9JQE8;uniprot:A0A384DVL6;uniprot:H0YGK8;uniprot:H7C1J7 TNF GeneProduct ensembl:ENSG00000204490 PTCRA GeneProduct ensembl:ENSG00000171611 ensembl:ENSG00000171611 ncbigene:171558 hgnc.symbol:PTCRA uniprot:Q6ISU1;uniprot:A0A087WTE9 DVL2 GeneProduct ensembl:ENSG00000004975 ensembl:ENSG00000004975 ncbigene:1856 hgnc.symbol:DVL2 uniprot:I3L0M7;uniprot:I3L2N2;uniprot:I3L2W9;uniprot:O14641;uniprot:I3L0Z8 CREBBP GeneProduct ensembl:ENSG00000005339 ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293 DTX3L GeneProduct ensembl:ENSG00000163840 ensembl:ENSG00000163840 ncbigene:151636 hgnc.symbol:DTX3L uniprot:Q8TDB6 GCN5L2 GeneProduct ensembl:ENSG00000108773 ensembl:ENSG00000108773 ncbigene:2648 hgnc.symbol:KAT2A uniprot:K7EPC4;uniprot:Q92830;uniprot:K7ERS6 APH1A GeneProduct ensembl:ENSG00000117362 ensembl:ENSG00000117362 ncbigene:51107 hgnc.symbol:APH1A uniprot:Q96BI3;uniprot:Q5TB21 NOTCH3 GeneProduct ensembl:ENSG00000074181 ensembl:ENSG00000074181 ncbigene:4854 hgnc.symbol:NOTCH3 uniprot:M0QZN3;uniprot:Q9UM47;uniprot:M0R3C9;uniprot:M0QX38 DTX1 GeneProduct ensembl:ENSG00000135144 ensembl:ENSG00000135144 ncbigene:1840 hgnc.symbol:DTX1 uniprot:Q86Y01 ADAM17 GeneProduct ensembl:ENSG00000151694 ensembl:ENSG00000151694 ncbigene:6868 hgnc.symbol:ADAM17 uniprot:P78536;uniprot:B2RNB2;uniprot:A6H8L4;uniprot:A0A3B3ITW9;uniprot:A0A3B3ITB5;uniprot:A0A3B3ISQ1;uniprot:A0A3B3IST4 NOTCH2 GeneProduct ensembl:ENSG00000134250 ensembl:ENSG00000134250 ncbigene:4853 hgnc.symbol:NOTCH2 uniprot:D2WEZ3;uniprot:A0A494C049;uniprot:A0A494C1U9;uniprot:R4GN02;uniprot:A0A494C1H8;uniprot:Q04721;uniprot:A0A494C1F1;uniprot:A0A1W2PQQ5 DLL1 GeneProduct ensembl:ENSG00000198719 ensembl:ENSG00000198719 ncbigene:28514 hgnc.symbol:DLL1 uniprot:A0A0D9SF76;uniprot:A0A384P5C6;uniprot:O00548 RBPJ GeneProduct ncbigene:3516 aka RBP-Jkappa aka CBF1. Serves as a co-factor for the processed notch receptor after translocation to the nucleus to activate down-stream notch transcription. PMID: 15187023. In the nucleus, NIC (processed notch) regulates transcription through association with the DNA-binding protein RBP-J (also known as CBF1, KBF2, or CSL). The primary gene targets of RBP-J include members of the hairy and enhancer of split (HES) and hairy related transcription factor (HRT) families of basic-helix-loop-helix transcriptional repressors. In the absence of NIC, RBP-J actively represses transcription by way of recruitment of a corepressor complex.8 Nuclear translocation of NIC leads to dissociation of repressor proteins from RBP-J and formation of a coactivator complex.9-13. PMID: 15194757. RBP-J is a downstream target of the Notch pathway, a conserved signal transduction pathway that is important in development and cell fate determination (43). The intracellular domain (ICD) of activated Notch is released from the membrane through proteolytic cleavage and is translocated to the nucleus, where it is directed to target promoters through interaction with RBP-J (47, 68). RBP-J is a repressor in the ground state; its interaction with Notch ICD relieves this repression and turns on target genes. Interestingly, KSHV is not the only virus that has parasitized this pathway. Several viral transcription factors, e.g., EBNA2 and EBNA3 of Epstein-Barr virus and the 13S isoform of adenovirus E1A, are known to bind and activate target genes via RBP-J interactions (1, 22, 25, 26, 29). In all cases, the viral proteins target the same (central repressive) domain of RBP-J that is targeted by Notch, although KSHV RTA is capable of interactions with an additional region of RBP-J in vitro (33). RBP-J can bind RTA and recruit it to its cognate recognition site; when this happens, the activation function of RTA can relieve RBP-J-mediated repression and upregulate expression of the targeted gene. EMSA studies reveal that both sites A and C can bind to RBP-J; sequence inspection reveals that site A is a novel functional variant of known RBP-J recognition sites. 
 
 ensembl:ENSG00000168214 ncbigene:3516 hgnc.symbol:RBPJ uniprot:D6RIV8;uniprot:Q06330;uniprot:D6RBQ8;uniprot:D6R9X3;uniprot:D6REC2;uniprot:D6R946;uniprot:D6RAT2;uniprot:D6RE93;uniprot:D6R927;uniprot:D6R9K5;uniprot:D6RA45;uniprot:H0Y8R3;uniprot:D6REP3;uniprot:D6RCM1;uniprot:D6RIZ8;uniprot:D6RB37;uniprot:D6RF98 DVL1 GeneProduct ensembl:ENSG00000107404 ensembl:ENSG00000107404 ncbigene:1855 hgnc.symbol:DVL1 uniprot:A0A087WWA7;uniprot:A0A0J9YWZ5;uniprot:O14640;uniprot:A0A0J9YYK1 DLL4 GeneProduct ensembl:ENSG00000128917 ensembl:ENSG00000128917 ncbigene:54567 hgnc.symbol:DLL4 uniprot:Q9NR61 NUMBL GeneProduct ensembl:ENSG00000105245 ensembl:ENSG00000105245 ncbigene:9253 hgnc.symbol:NUMBL uniprot:M0R0Q4;uniprot:A0A0C4DGH3;uniprot:Q9Y6R0;uniprot:M0QYC2;uniprot:M0QXQ4;uniprot:M0QZV7 RFNG GeneProduct ensembl:ENSG00000169733 ensembl:ENSG00000169733 ncbigene:5986 hgnc.symbol:RFNG uniprot:F5H3H7;uniprot:J3QLN0;uniprot:Q9Y644 NCSTN GeneProduct ensembl:ENSG00000162736 ensembl:ENSG00000162736 ncbigene:23385 hgnc.symbol:NCSTN uniprot:A0A2U3TZL9;uniprot:A0A2R8YE20;uniprot:H0Y3Z4;uniprot:Q5T209;uniprot:H0Y6T7;uniprot:Q5T205;uniprot:Q5T211;uniprot:Q5T210;uniprot:A0A2R8YCK1;uniprot:Q92542 NOTCH4 GeneProduct ensembl:ENSG00000204301 ensembl:ENSG00000204301 ncbigene:4855 hgnc.symbol:NOTCH4 uniprot:Q99466;uniprot:A0A1U9X983 NOTCH1 GeneProduct ensembl:ENSG00000148400 ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:P46531 CIR GeneProduct ncbigene:3762 ensembl:ENSG00000120457 ncbigene:3762 hgnc.symbol:KCNJ5 uniprot:P48544;uniprot:A0A5J6E2W8 CTBP1 GeneProduct ensembl:ENSG00000159692 ensembl:ENSG00000159692 ncbigene:1487 hgnc.symbol:CTBP1 uniprot:A0A0D9SGE6;uniprot:D6RAX2;uniprot:E9PGB1;uniprot:H0Y913;uniprot:X5D8Y5;uniprot:E7EPF8;uniprot:E7ESU7;uniprot:Q13363;uniprot:E7EUB3;uniprot:H0Y8U5;uniprot:H0Y8W7;uniprot:H0Y9M9 SKIP GeneProduct ensembl:ENSG00000132376 ensembl:ENSG00000132376 ncbigene:51763 hgnc.symbol:INPP5K uniprot:C9JQW8;uniprot:I3L0Y0;uniprot:I3L2L1;uniprot:I3L4A5;uniprot:K7ENF7;uniprot:K7EPG6;uniprot:I3NI31;uniprot:J3KN07;uniprot:I3L1R1;uniprot:Q9BT40;uniprot:C9JZB0;uniprot:K7EMS8 MFNG GeneProduct ensembl:ENSG00000100060 ensembl:ENSG00000100060 ncbigene:4242 hgnc.symbol:MFNG uniprot:A0A1B0GX02;uniprot:H0Y6Q9;uniprot:A9UJQ1;uniprot:F8WE05;uniprot:O00587;uniprot:A9UJP9;uniprot:F8WE21 HES5 GeneProduct ensembl:ENSG00000197921 ensembl:ENSG00000197921 ncbigene:388585 hgnc.symbol:HES5 uniprot:Q5TA89 HES1 GeneProduct ensembl:ENSG00000114315 ensembl:ENSG00000114315 ncbigene:3280 hgnc.symbol:HES1 uniprot:Q14469 DTX4 GeneProduct ensembl:ENSG00000110042 ensembl:ENSG00000110042 ncbigene:23220 hgnc.symbol:DTX4 uniprot:Q9Y2E6 PSEN1 GeneProduct ensembl:ENSG00000080815 ensembl:ENSG00000080815 ncbigene:5663 hgnc.symbol:PSEN1 uniprot:G3V490;uniprot:G3V5B1;uniprot:A0A0S2Z4D2;uniprot:A0A024R6A3;uniprot:P49768;uniprot:G3V3Z0;uniprot:G3V519;uniprot:E7ES96;uniprot:H0YM52;uniprot:G3V2G7;uniprot:H0YNU4;uniprot:G3V2B1;uniprot:G3V499;uniprot:G3V3P0;uniprot:G3V4P4;uniprot:G3V4M0;uniprot:G3V449 MAML3 GeneProduct ensembl:ENSG00000196782 ensembl:ENSG00000196782 ncbigene:55534 hgnc.symbol:MAML3 uniprot:Q96JK9;uniprot:H0Y920;uniprot:E7ESR8 CTBP2 GeneProduct ensembl:ENSG00000175029 ensembl:ENSG00000175029 ncbigene:1488 hgnc.symbol:CTBP2 uniprot:A0A087WYL1;uniprot:P56545 PCAF GeneProduct ensembl:ENSG00000114166 ensembl:ENSG00000114166 ncbigene:8850 hgnc.symbol:KAT2B uniprot:Q92831 HDAC2 GeneProduct ensembl:ENSG00000196591 ensembl:ENSG00000196591 ncbigene:3066 hgnc.symbol:HDAC2 uniprot:E5RGV4;uniprot:E5RH52;uniprot:E5RFI6;uniprot:E5RK19;uniprot:E5RHE7;uniprot:E5RJ04;uniprot:Q92769;uniprot:E5RG37;uniprot:H3BM24;uniprot:E5RFP9 NICD Protein wikidata:Q50257903