Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI RBP-J GeneProduct ncbigene:19664 "aka RBP-Jkappa aka CBF1. Serves as a co-factor for the processed notch receptor after translocation to the nucleus to activate down-stream notch transcription. PMID: 15187023. In the nucleus, NIC (processed notch) regulates transcription through association with the DNA-binding protein RBP-J (also known as CBF1, KBF2, or CSL). The primary gene targets of RBP-J include members of the hairy and enhancer of split (HES) and hairy related transcription factor (HRT) families of basic-helix-loop-helix transcriptional repressors. In the absence of NIC, RBP-J actively represses transcription by way of recruitment of a corepressor complex.8 Nuclear translocation of NIC leads to dissociation of repressor proteins from RBP-J and formation of a coactivator complex.9-13. PMID: 15194757. RBP-J is a downstream target of the Notch pathway, a conserved signal transduction pathway that is important in development and cell fate determination (43). The intracellular domain (ICD) of activated Notch is released from the membrane through proteolytic cleavage and is translocated to the nucleus, where it is directed to target promoters through interaction with RBP-J (47, 68). RBP-J is a repressor in the ground state; its interaction with Notch ICD relieves this repression and turns on target genes. Interestingly, KSHV is not the only virus that has parasitized this pathway. Several viral transcription factors, e.g., EBNA2 and EBNA3 of Epstein-Barr virus and the 13S isoform of adenovirus E1A, are known to bind and activate target genes via RBP-J interactions (1, 22, 25, 26, 29). In all cases, the viral proteins target the same (central repressive) domain of RBP-J that is targeted by Notch, although KSHV RTA is capable of interactions with an additional region of RBP-J in vitro (33). RBP-J can bind RTA and recruit it to its cognate recognition site; when this happens, the activation function of RTA can relieve RBP-J-mediated repression and upregulate expression of the targeted gene. EMSA studies reveal that both sites A and C can bind to RBP-J; sequence inspection reveals that site A is a novel functional variant of known RBP-J recognition sites." ensembl:ENSMUSG00000039191 ncbigene:19664 uniprot:A0A0J9YTV5;uniprot:A0A0J9YVE0;uniprot:E9Q7W0;uniprot:Q3U6F1;uniprot:Q3UM17;uniprot:P31266 Jag1 GeneProduct ncbigene:16449 "" ensembl:ENSMUSG00000027276 ncbigene:16449 uniprot:Q9QXX0;uniprot:Q3UVN4 Maml3 GeneProduct ncbigene:433586 "" ensembl:ENSMUSG00000061143 ncbigene:433586 uniprot:E9Q6E8;uniprot:D4QGC2 Dtx1 GeneProduct ncbigene:14357 "" ensembl:ENSMUSG00000029603 ncbigene:14357 uniprot:Q61010 Hdac2 GeneProduct ncbigene:15182 "" ensembl:ENSMUSG00000019777 ncbigene:15182 uniprot:A0A0R4J008;uniprot:Q8BQ10 Dvl3 GeneProduct ncbigene:13544 "" ensembl:ENSMUSG00000003233 ncbigene:13544 uniprot:E9Q150;uniprot:Q61062;uniprot:E9Q967 Adam17 GeneProduct ncbigene:11491 "" ensembl:ENSMUSG00000052593 ncbigene:11491 uniprot:E9PXU2;uniprot:Q9Z0F8;uniprot:J3QNB3;uniprot:A0A338P6I8;uniprot:J3QMF2;uniprot:A0A338P6F3 Ctbp2 GeneProduct ncbigene:13017 "" ensembl:ENSMUSG00000030970 ncbigene:13017 uniprot:E9Q4S8;uniprot:Q91YZ2;uniprot:E9PZG2;uniprot:E9Q815;uniprot:E9PWQ9;uniprot:E9Q0T4;uniprot:E9PX05;uniprot:E9QA96;uniprot:Q3UGL5;uniprot:E9Q0V8;uniprot:E9Q123;uniprot:P56546 Notch3 GeneProduct ncbigene:18131 "" ensembl:ENSMUSG00000038146 ncbigene:18131 uniprot:A0A494BAZ6;uniprot:Q61982 Maml1 GeneProduct ncbigene:103806 "" ensembl:ENSMUSG00000050567 ncbigene:103806 uniprot:F6UY95;uniprot:Q6T264 Dvl2 GeneProduct ncbigene:13543 "" ensembl:ENSMUSG00000020888 ncbigene:13543 uniprot:Q60838 Dvl1 GeneProduct ncbigene:13542 "" ensembl:ENSMUSG00000029071 ncbigene:13542 uniprot:P51141 CIR GeneProduct ncbigene:66935 "" ensembl:ENSMUSG00000041777 ncbigene:66935 uniprot:Q9DA19 Ncstn GeneProduct ncbigene:59287 "" ensembl:ENSMUSG00000003458 ncbigene:59287 uniprot:D6RCJ2;uniprot:P57716 Aph1a GeneProduct ncbigene:226548 "" ensembl:ENSMUSG00000015750 ncbigene:226548 uniprot:Q8BVF7;uniprot:A0A0G2JF05;uniprot:Q6GTF1 RBPSUHL GeneProduct ncbigene:19668 "" ensembl:ENSMUSG00000017007 ncbigene:19668 uniprot:Q3V2I2;uniprot:O08674 Notch1 GeneProduct ncbigene:18128 "" ensembl:ENSMUSG00000026923 ncbigene:18128 uniprot:A2AIX5;uniprot:Q01705 Ncor2 GeneProduct ncbigene:20602 "" ensembl:ENSMUSG00000029478 ncbigene:20602 uniprot:E9Q701;uniprot:F6YAU7;uniprot:F6Z4B2;uniprot:E9Q9V3;uniprot:F6SK53;uniprot:Q9WU42;uniprot:D3Z2J5;uniprot:E9PY55;uniprot:A0A0G2JEQ5;uniprot:F8VQL9;uniprot:A0A0G2JED1 Numb GeneProduct ncbigene:18222 "" ensembl:ENSMUSG00000021224 ncbigene:18222 uniprot:Q05BE7;uniprot:Q9QZS3;uniprot:D3Z7J1;uniprot:A0A1Y7VJJ7;uniprot:D3Z549;uniprot:F8WJ71;uniprot:D3Z1E8;uniprot:D3Z7I6 Dtx3l GeneProduct ncbigene:209200 "" ensembl:ENSMUSG00000049502 ncbigene:209200 uniprot:Q3UIR3 Dll1 GeneProduct ncbigene:13388 "" ensembl:ENSMUSG00000014773 ncbigene:13388 uniprot:A0A338P7A6;uniprot:Q61483 SKIP GeneProduct ncbigene:66354 "" ensembl:ENSMUSG00000021039 ncbigene:66354 uniprot:A0A0B4J1E2 Psen2 GeneProduct ncbigene:19165 "" ensembl:ENSMUSG00000010609 ncbigene:19165 uniprot:Q3U4P5;uniprot:D3Z0X1;uniprot:A0A0R4J1F2 Dll4 GeneProduct ncbigene:54485 "" ensembl:ENSMUSG00000027314 ncbigene:54485 uniprot:Q9JI71 Notch2 GeneProduct ncbigene:18129 "" ensembl:ENSMUSG00000027878 ncbigene:18129 uniprot:O35516 Notch4 GeneProduct ncbigene:18132 "" ensembl:ENSMUSG00000015468 ncbigene:18132 uniprot:G3UX69;uniprot:G3UZH3;uniprot:P31695 Crebbp GeneProduct ncbigene:12914 "" ensembl:ENSMUSG00000022521 ncbigene:12914 uniprot:A0A0U1RP23;uniprot:A0A0U1RP46;uniprot:A0A0U1RPQ3;uniprot:A0A0U1RQB6;uniprot:A0A0U1RPL2;uniprot:F8VPR5 Dtx3 GeneProduct ncbigene:80904 "" ensembl:ENSMUSG00000040415 ncbigene:80904 uniprot:D3Z4X6;uniprot:Q80V91;uniprot:E9Q3J1;uniprot:D3YUA4;uniprot:D3YV13 Dtx2 GeneProduct ncbigene:74198 "" ensembl:ENSMUSG00000004947 ncbigene:74198 uniprot:A0A0R4IZY1;uniprot:A0A0G2JDR7;uniprot:A0A1C7ZMZ6;uniprot:Q8R3P2 Hes1 GeneProduct ncbigene:15205 "" ensembl:ENSMUSG00000022528 ncbigene:15205 uniprot:P35428;uniprot:Q3UZZ2 PCAF GeneProduct uniprot:Q9JHD1 "" ensembl:ENSMUSG00000000708 ncbigene:18519 uniprot:F6SIC5;uniprot:Q9JHD1;uniprot:B2RR30;uniprot:F6ZCH1;uniprot:E9Q1F7 Dtx4 GeneProduct ncbigene:207521 "" ensembl:ENSMUSG00000039982 ncbigene:207521 uniprot:Q6PDK8 Lfng GeneProduct ncbigene:16848 "" ensembl:ENSMUSG00000029570 ncbigene:16848 uniprot:B2RRW2;uniprot:O09010 Hdac1 GeneProduct ncbigene:433759 "" ensembl:ENSMUSG00000028800 ncbigene:433759 uniprot:Q58E49;uniprot:O09106 Jag2 GeneProduct ncbigene:16450 "" ensembl:ENSMUSG00000002799 ncbigene:16450 uniprot:A0A1Y7VLS8;uniprot:Q9QYE5 Psen1 GeneProduct ncbigene:19164 "" ensembl:ENSMUSG00000019969 ncbigene:19164 uniprot:P49769;uniprot:Q3UYK2 Ctbp1 GeneProduct ncbigene:13016 "" ensembl:ENSMUSG00000037373 ncbigene:13016 uniprot:A0A0J9YU62;uniprot:A0A0J9YTW3;uniprot:A0A0J9YVI3;uniprot:A0A0J9YUM4;uniprot:O88712;uniprot:A0A0J9YUR5;uniprot:A0A0J9YU66;uniprot:A0A0J9YVC3 Dll3 GeneProduct ncbigene:13389 "" ensembl:ENSMUSG00000003436 ncbigene:13389 uniprot:Q3UND5;uniprot:O88516 Mfng GeneProduct ncbigene:17305 "" ensembl:ENSMUSG00000018169 ncbigene:17305 uniprot:Q3UPI0;uniprot:O09008 Numbl GeneProduct ncbigene:18223 "" ensembl:ENSMUSG00000063160 ncbigene:18223 uniprot:O08919 Tnf GeneProduct ncbigene:21926 "" ensembl:ENSMUSG00000024401 ncbigene:21926 uniprot:P06804;uniprot:A0A0R4J210;uniprot:Q3U593 Rfng GeneProduct ncbigene:19719 "" ensembl:ENSMUSG00000025158 ncbigene:19719 uniprot:O09009 Ptcra GeneProduct ncbigene:19208 "" ensembl:ENSMUSG00000036858 ncbigene:19208 uniprot:A0A0R4J0F4 Aph1b GeneProduct ncbigene:208117 "" ensembl:ENSMUSG00000032375 ncbigene:208117 uniprot:Q3TRQ2;uniprot:Q8C7N7;uniprot:F8WHK7 GCN5L2 GeneProduct ncbigene:14534 "" ensembl:ENSMUSG00000020918 ncbigene:14534 uniprot:Q9JHD2;uniprot:Q6P3Z8 Hes5 GeneProduct ncbigene:15208 "" ensembl:ENSMUSG00000048001 ncbigene:15208 uniprot:P70120;uniprot:Q499J8