Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI N-Acetylserotonin Metabolite chebi:17697 wikidata:Q4847704 chebi:17697;chebi:17697 inchikey:MVAWJSIDNICKHF-UHFFFAOYSA-N Serotonin Metabolite chebi:28790 wikidata:Q167934 chebi:28790;chebi:28790 inchikey:QZAYGJVTTNCVMB-UHFFFAOYSA-N Lipopolysaccharide Metabolite chebi:16412 wikidata:Q421804 chebi:16412;chebi:16412 inchikey:BFVQTKQTUCQRPI-YYEZTRBPSA-N 5-Hydroxyindoleacetic acid Metabolite chebi:27823 wikidata:Q238532 chebi:27823;chebi:27823 inchikey:DUUGKQCEGZLZNO-UHFFFAOYSA-N free radicals Metabolite chebi:26519 wikidata:Q185056 chebi:26519;chebi:26519 Pinoline Metabolite pubchem.compound:1868 wikidata:Q3905316 inchikey:QYMDEOQLJUUNOF-UHFFFAOYSA-N 5-Methoxytryptamine Metabolite chebi:2089 0-methylserotonin wikidata:Q4352011 chebi:2089;chebi:2089 inchikey:JTEJPPKMYBDEMY-UHFFFAOYSA-N Melatonin Metabolite chebi:16796 wikidata:Q180912 chebi:16796;chebi:16796 inchikey:DRLFMBDRBRZALE-UHFFFAOYSA-N cyclic 6-hydroxymelatonin Metabolite hmdb:HMDB0060810 inchikey:FQZIOEARFRBPDV-UHFFFAOYSA-N Ethinhyloestradiol Metabolite pubchem.compound:5991 wikidata:Q415563 chebi:4903;chebi:4903 inchikey:BFPYWIDHMRZLRN-SLHNCBLASA-N 6-Sulfatoxymelatonin Metabolite hmdb:HMDB0041815 inchikey:QQEILXDLZRLTME-UHFFFAOYSA-N cAMP Metabolite chebi:17489 wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N N,N-Dimethyltryptamine Metabolite chebi:28969 wikidata:Q407217 chebi:28969;chebi:28969 inchikey:DMULVCHRPCFFGV-UHFFFAOYSA-N 5-methoxypsoralen Metabolite pubchem.compound:2355 wikidata:Q414779 chebi:18293;chebi:18293 inchikey:BGEBZHIAGXMEMV-UHFFFAOYSA-N Noradrenaline Metabolite chebi:33569 wikidata:Q27087994 chebi:33569;chebi:33569 inchikey:SFLSHLFXELFNJZ-UHFFFAOYSA-N 6-Hydroxymelatonin Metabolite chebi:2198 wikidata:Q20707319 chebi:2198;chebi:2198 inchikey:OMYMRCXOJJZYKE-UHFFFAOYSA-N;inchikey:BRPLOVMHAFXVOQ-HUMIJZDLSA-N Bufotenin Metabolite chebi:3210 wikidata:Q408915 chebi:3210;chebi:3210 inchikey:VTTONGPRPXSUTJ-UHFFFAOYSA-N cAMP Metabolite chebi:17489 wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N cyclic 3-hydroxymelatonin Metabolite hmdb:HMDB0060069 inchikey:VADOSKJWFKUPQF-UHFFFAOYSA-N MAP2 GeneProduct ensembl:ENSG00000078018 ensembl:ENSG00000078018 ncbigene:4133 hgnc.symbol:MAP2 uniprot:A0A024R409;uniprot:P11137;uniprot:A8MZ31;uniprot:A0A669KB77;uniprot:H7BZB9;uniprot:E7EV03 MTNR1B GeneProduct ensembl:ENSG00000134640 ensembl:ENSG00000134640 ncbigene:4544 hgnc.symbol:MTNR1B uniprot:E9PR36;uniprot:H0YDG4;uniprot:P49286 SULT1A1 GeneProduct ensembl:ENSG00000196502 ensembl:ENSG00000196502 ncbigene:6817 hgnc.symbol:SULT1A1 uniprot:P50225;uniprot:H3BT96;uniprot:H3BMH9;uniprot:H3BQX5;uniprot:H3BRY5 EDN1 GeneProduct ensembl:ENSG00000078401 ensembl:ENSG00000078401 ncbigene:1906 hgnc.symbol:EDN1 uniprot:P05305;uniprot:Q6FH53 CAM GeneProduct ensembl:ENSG00000198668 calmodulin 1, CALM1 ensembl:ENSG00000198668 ncbigene:801 hgnc.symbol:CALM1 uniprot:G3V361;uniprot:P0DP23;uniprot:G3V226;uniprot:G3V479;uniprot:Q96HY3;uniprot:B4DJ51 CYP1B1 GeneProduct ensembl:ENSG00000138061 Low expression in liver, high expression in (fetal) brain and kidney ensembl:ENSG00000138061 ncbigene:1545 hgnc.symbol:CYP1B1 uniprot:A0A087WUQ7;uniprot:A0A087WW26;uniprot:Q16678 ACHE GeneProduct ensembl:ENSG00000087085 AAA (aryl-acylamidase) is a subfunction of ACHE ensembl:ENSG00000087085 ncbigene:43 hgnc.symbol:ACHE uniprot:C9J2S3;uniprot:C9JZL6;uniprot:F8WAR7;uniprot:F8WD68;uniprot:P22303;uniprot:A0A498U6H7;uniprot:F8WD34;uniprot:C9JD78 CaMK2 GeneProduct ensembl:ENSG00000070808 ensembl:ENSG00000070808 ncbigene:815 hgnc.symbol:CAMK2A uniprot:A0A5F9ZH21;uniprot:A0A5K1VW76;uniprot:D6RFJ0;uniprot:A8K161;uniprot:A0A5F9ZHR5;uniprot:Q7LDD5;uniprot:Q9UQM7;uniprot:A0A5F9ZH50;uniprot:A0A5F9ZHM9;uniprot:A0A5F9ZHY2 ARNTL GeneProduct ensembl:ENSG00000133794 ensembl:ENSG00000133794 ncbigene:406 hgnc.symbol:ARNTL uniprot:A0A669KB07;uniprot:E9PL54;uniprot:O00327;uniprot:E9PKN1;uniprot:A0A140VKD3;uniprot:A0A669KAV4;uniprot:A0A669KAX2;uniprot:E9PKG7;uniprot:E9PNI4;uniprot:H0YER9;uniprot:E9PRB1;uniprot:E9PSD2;uniprot:A0A669KBF4;uniprot:E9PI92 CYP2D6 GeneProduct ensembl:ENSG00000100197 proven only for rat ensembl:ENSG00000100197 ncbigene:107987478;ncbigene:1565;ncbigene:107987479 hgnc.symbol:CYP2D6 uniprot:P10635;uniprot:C1ID52;uniprot:H7BY38 TRAF6 GeneProduct ensembl:ENSG00000175104 ensembl:ENSG00000175104 ncbigene:7189 hgnc.symbol:TRAF6 uniprot:Q9Y4K3 IRAK1 GeneProduct ensembl:ENSG00000184216 ensembl:ENSG00000184216 ncbigene:3654 hgnc.symbol:IRAK1 uniprot:H7C1F0;uniprot:P51617;uniprot:D3YTB5;uniprot:H7C224;uniprot:H7C3G8;uniprot:H7C3C1;uniprot:F8WAB6;uniprot:H7C2I6 PER2 GeneProduct ensembl:ENSG00000132326 ensembl:ENSG00000132326 ncbigene:8864 hgnc.symbol:PER2 uniprot:E9PD89;uniprot:O15055 MTNR1A GeneProduct ensembl:ENSG00000168412 ensembl:ENSG00000168412 ncbigene:4543 hgnc.symbol:MTNR1A uniprot:P48039 CLOCK GeneProduct ensembl:ENSG00000134852 ensembl:ENSG00000134852 ncbigene:9575 hgnc.symbol:CLOCK uniprot:C9JK03;uniprot:O15516 PKC GeneProduct ensembl:ENSG00000154229 PCK - alpha (literature does not give the exact subclass of PCK) ensembl:ENSG00000154229 ncbigene:5578 hgnc.symbol:PRKCA uniprot:J3KN97;uniprot:L7RSM7;uniprot:P17252;uniprot:J3KRN5 AANAT GeneProduct ensembl:ENSG00000129673 ensembl:ENSG00000129673 ncbigene:15 hgnc.symbol:AANAT uniprot:Q16613;uniprot:F1T0I5;uniprot:K7ERF6;uniprot:K7ESH7 GSK3B GeneProduct ensembl:ENSG00000082701 ensembl:ENSG00000082701 ncbigene:2932 hgnc.symbol:GSK3B uniprot:A0A3B3ITW1;uniprot:A0A7I2V4F3;uniprot:A0A7I2YQ81;uniprot:A0A7I2V5B5;uniprot:A0A7I2V3D8;uniprot:A0A7I2V2Y0;uniprot:A0A7I2YQU1;uniprot:A0A7I2YQK0;uniprot:A0A7I2V2U4;uniprot:A0A7I2V441;uniprot:A0A7I2V4W7;uniprot:A0A7I2V589;uniprot:A0A7I2V3S5;uniprot:A0A7I2YQK2;uniprot:A0A7I2V5M2;uniprot:A0A7I2V626;uniprot:A0A7I2V606;uniprot:A0A7I2V2I5;uniprot:A0A7I2V2K7;uniprot:A0A7I2V3K8;uniprot:A0A7I2YQG6;uniprot:A0A7I2V4G2;uniprot:P49841;uniprot:A0A7I2V5G5;uniprot:A0A7I2V5K9;uniprot:A0A7I2V3A4;uniprot:A0A7I2V3G9;uniprot:Q6FI27;uniprot:A0A7I2V3Z5;uniprot:A0A7I2V4X2;uniprot:A0A7I2V2T2;uniprot:A0A7I2V2V4;uniprot:A0A7I2V4X3;uniprot:A0A7I2V3T3;uniprot:A0A7I2V675;uniprot:A0A7I2V432;uniprot:A0A7I2V2N4;uniprot:A0A7I2V5P4;uniprot:A0A7I2YQB0;uniprot:A0A7I2V3N7;uniprot:A0A7I2V3J4 SIRT1 GeneProduct ensembl:ENSG00000096717 ensembl:ENSG00000096717 ncbigene:23411 hgnc.symbol:SIRT1 uniprot:A0A024QZQ1;uniprot:E9PC49;uniprot:Q96EB6;uniprot:B0QZ35 ADRB GeneProduct ensembl:ENSG00000043591 ensembl:ENSG00000043591 ncbigene:153 hgnc.symbol:ADRB1 uniprot:P08588 NFKB1 GeneProduct ensembl:ENSG00000109320 ensembl:ENSG00000109320 ncbigene:4790 hgnc.symbol:NFKB1 uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:D6RF93;uniprot:P19838;uniprot:D6RC45;uniprot:D6RDI9;uniprot:D6RH30 FOXO1 GeneProduct ensembl:ENSG00000150907 ensembl:ENSG00000150907 ncbigene:2308 hgnc.symbol:FOXO1 uniprot:Q12778 CYP1A1 GeneProduct ensembl:ENSG00000140465 ensembl:ENSG00000140465 ncbigene:1543 hgnc.symbol:CYP1A1 uniprot:E7EMT5;uniprot:P04798;uniprot:A0N0X8;uniprot:A4F3V8 PER3 GeneProduct ensembl:ENSG00000049246 ensembl:ENSG00000049246 ncbigene:8863 hgnc.symbol:PER3 uniprot:A2I2N5;uniprot:Q8TAR6;uniprot:A0A087WV69;uniprot:P56645 ECE-1 GeneProduct ensembl:ENSG00000117298 ensembl:ENSG00000117298 ncbigene:1889 hgnc.symbol:ECE1 uniprot:A0A024RAB0;uniprot:A0A024RAB2;uniprot:B4DKB2;uniprot:A0A3B3ISF9;uniprot:E9PHZ1;uniprot:P42892;uniprot:A1PUP8;uniprot:E9PN99;uniprot:E9PJG1 APOE GeneProduct uniprot:P02649 ensembl:ENSG00000130203 ncbigene:348 hgnc.symbol:APOE uniprot:H0Y7L5;uniprot:A0A0S2Z3D5;uniprot:P02649;uniprot:E7ERP7;uniprot:E9PEV4 PER1 GeneProduct ensembl:ENSG00000179094 ensembl:ENSG00000179094 ncbigene:5187 hgnc.symbol:PER1 uniprot:J3KRL7;uniprot:J3KSL6;uniprot:J3QSH9;uniprot:J3QLQ5;uniprot:J3QL46;uniprot:J3KTM2;uniprot:J3QL55;uniprot:O15534 CYP1A2 GeneProduct ensembl:ENSG00000140505 Synonym CP12, P3-450
Main melatonin hydroxylating enzyme ensembl:ENSG00000140505 ncbigene:1544 hgnc.symbol:CYP1A2 uniprot:P05177 ASMT GeneProduct ensembl:ENSG00000196433 ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 CYP2C19 GeneProduct ensembl:ENSG00000165841 ensembl:ENSG00000165841 ncbigene:1557 hgnc.symbol:CYP2C19 uniprot:P33261;uniprot:A0A087X125 CRY2 GeneProduct ensembl:ENSG00000121671 ensembl:ENSG00000121671 ncbigene:1408 hgnc.symbol:CRY2 uniprot:A0A0D2X7Z3;uniprot:A2I2P1;uniprot:Q49AN0 CRY1 GeneProduct ensembl:ENSG00000008405 ensembl:ENSG00000008405 ncbigene:1407 hgnc.symbol:CRY1 uniprot:Q16526;uniprot:A2I2P0;uniprot:H0YHT0 Clock Protein ensembl:ENSP00000426983 Cry Protein ensembl:ENSP00000008527 CSNK1D Protein ensembl:ENSG00000141551 ensembl:ENSG00000141551 ncbigene:1453 hgnc.symbol:CSNK1D uniprot:J3KRM8;uniprot:P48730;uniprot:H7BYT1;uniprot:H0Y2N6;uniprot:J3QQU8;uniprot:J3QQI9;uniprot:J3KRS6;uniprot:B4DLF1;uniprot:J3QS70 MAOA Protein ensembl:ENSG00000189221 ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 Arntl Protein ensembl:ENSP00000374357 Per Protein ensembl:ENSP00000314420 CSNK1E Protein ensembl:ENSG00000213923 ensembl:ENSG00000213923 ncbigene:1454 hgnc.symbol:CSNK1E uniprot:H7C3J2;uniprot:H7C0Y5;uniprot:Q5U045;uniprot:H0Y682;uniprot:P49674;uniprot:H0Y5S9;uniprot:B0QY36;uniprot:H0Y645;uniprot:B0QY35;uniprot:B0QY34;uniprot:A0A669KBC0 Per Protein ensembl:ENSP00000314420 Cry Protein ensembl:ENSP00000008527 AANAT Protein ensembl:ENSP00000250615