ID Database Citation 8702689 Pubmed "Kenner KA, Anyanwu E, Olefsky JM, Kusari J. Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J Biol Chem. 1996 Aug 16;271(33):19810–6. PubMed Europe PMC Scholia" 8826975 Pubmed "Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, et al. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes. 1996 Oct;45(10):1379–85. PubMed Europe PMC Scholia" 9094314 Pubmed "Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol. 1997 Apr 1;7(4):261–9. PubMed Europe PMC Scholia" 9228007 Pubmed "Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997 Jul 25;277(5325):567–70. PubMed Europe PMC Scholia" 10692429 Pubmed "Calera MR, Vallega G, Pilch PF. Dynamics of protein-tyrosine phosphatases in rat adipocytes. J Biol Chem. 2000 Mar 3;275(9):6308–12. PubMed Europe PMC Scholia" 11282018 Pubmed "Bevan P. Insulin signalling. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia" 11742412 Pubmed "Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia" 11803135 Pubmed "Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan Y-JY. The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Eur J Pharm Sci. 2002 Feb;15(1):89–96. PubMed Europe PMC Scholia" 11875109 Pubmed "Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, et al. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol. 2002 Mar;16(3):506–14. PubMed Europe PMC Scholia" 15581595 Pubmed "Handschin C, Meyer UA. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia" 15610735 Pubmed "Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, et al. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell. 2004 Dec 22;16(6):919–28. PubMed Europe PMC Scholia" 16244323 Pubmed "Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R251-8. PubMed Europe PMC Scholia" 16493415 Pubmed "Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006 Feb;7(2):85–96. PubMed Europe PMC Scholia" 16916938 Pubmed "Guo S, Dunn SL, White MF. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Mol Endocrinol. 2006 Dec;20(12):3389–99. PubMed Europe PMC Scholia" 17234883 Pubmed "Marr MT 2nd, D’Alessio JA, Puig O, Tjian R. IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback. Genes Dev. 2007 Jan 15;21(2):175–83. PubMed Europe PMC Scholia" 19324998 Pubmed "Hashimoto K, Ishida E, Matsumoto S, Okada S, Yamada M, Satoh T, et al. Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone. Endocrinology. 2009 Jul;150(7):3417–24. PubMed Europe PMC Scholia" 19683471 Pubmed "Tanti J-F, Jager J. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol. 2009 Dec;9(6):753–62. PubMed Europe PMC Scholia" 20412774 Pubmed "Chen C-C, Jeon S-M, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, et al. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell. 2010 Apr 20;18(4):592–604. PubMed Europe PMC Scholia" 20698033 Pubmed "Yang YM, Han CY, Kim YJ, Kim SG. AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability. World J Gastroenterol. 2010 Aug 14;16(30):3731–42. PubMed Europe PMC Scholia" 21310851 Pubmed "Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, et al. MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation. Mol Endocrinol. 2011 Apr;25(4):584–96. PubMed Europe PMC Scholia" 21440577 Pubmed "Hay N. Interplay between FOXO, TOR, and Akt. Biochim Biophys Acta. 2011 Nov;1813(11):1965–70. PubMed Europe PMC Scholia" 21453770 Pubmed "Poupeau A, Postic C. Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors. Biochim Biophys Acta. 2011 Aug;1812(8):995–1006. PubMed Europe PMC Scholia" 21908933 Pubmed "Hashimoto K, Mori M. Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]. Endocr J. 2011;58(11):921–30. PubMed Europe PMC Scholia" 22569073 Pubmed "Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E334-51. PubMed Europe PMC Scholia" 23150577 Pubmed "Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19751–6. PubMed Europe PMC Scholia" 23261442 Pubmed "Fu Z, Yao F, Abou-Samra AB, Zhang R. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun. 2013 Jan 18;430(3):1126–31. PubMed Europe PMC Scholia" 23516131 Pubmed "Daemen S, Kutmon M, Evelo CT. A pathway approach to investigate the function and regulation of SREBPs. Genes Nutr. 2013 May;8(3):289–300. PubMed Europe PMC Scholia" 23802099 Pubmed "Vadlakonda L, Dash A, Pasupuleti M, Anil Kumar K, Reddanna P. The Paradox of Akt-mTOR Interactions. Front Oncol. 2013 Jun 20;3:165. PubMed Europe PMC Scholia" 24262987 Pubmed "Tseng Y-H, Ke P-Y, Liao C-J, Wu S-M, Chi H-C, Tsai C-Y, et al. Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism. Autophagy. 2014 Jan;10(1):20–31. PubMed Europe PMC Scholia" 24379912 Pubmed "Raghow R. Betatrophin: A liver-derived hormone for the pancreatic β-cell proliferation. World J Diabetes. 2013 Dec 15;4(6):234–7. PubMed Europe PMC Scholia" 24852694 Pubmed "Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep. 2014 May 23;4:5013. PubMed Europe PMC Scholia" 25720603 Pubmed "Chen J, Chen S, Huang P, Meng X-L, Clayton S, Shen J-S, et al. In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats. Diabetologia. 2015 May;58(5):1036–44. PubMed Europe PMC Scholia" 26235620 Pubmed "Yang G, Murashige DS, Humphrey SJ, James DE. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Rep. 2015 Aug 11;12(6):937–43. PubMed Europe PMC Scholia" 26254015 Pubmed "Lee J, Hong S-W, Park SE, Rhee E-J, Park C-Y, Oh K-W, et al. AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells. Mol Cell Endocrinol. 2015 Oct 15;414:148–55. PubMed Europe PMC Scholia" 26387753 Pubmed "Rong Guo X, Li Wang X, Chen Y, Hong Yuan Y, Mei Chen Y, Ding Y, et al. ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells. Exp Cell Res. 2016 Jul 15;345(2):158–67. PubMed Europe PMC Scholia" 26490400 Pubmed "Wang Y, Viscarra J, Kim S-J, Sul HS. Transcriptional regulation of hepatic lipogenesis. Nat Rev Mol Cell Biol. 2015 Nov;16(11):678–89. PubMed Europe PMC Scholia" 26499800 Pubmed "Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC. Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 2015 Dec 18;290(51):30551–61. PubMed Europe PMC Scholia" 26569053 Pubmed "Zhang Y, Li S, Donelan W, Xie C, Wang H, Wu Q, et al. Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase. Biochim Biophys Acta. 2016 Feb;1861(2):130–7. PubMed Europe PMC Scholia" 27410263 Pubmed "Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, et al. Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS One. 2016 Jul 13;11(7):e0159276. PubMed Europe PMC Scholia"