Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI GMP Metabolite cas:85-32-5 wikidata:Q422473 chebi:17345;chebi:17345 inchikey:RQFCJASXJCIDSX-UUOKFMHZSA-N ATP Metabolite cas:1927-31-7 wikidata:Q201090 chebi:16284;chebi:16284 inchikey:SUYVUBYJARFZHO-RRKCRQDMSA-N PRPF4 GeneProduct ncbigene:9128 ensembl:ENSG00000136875 ncbigene:9128 hgnc.symbol:PRPF4 uniprot:Q5T1M7;uniprot:O43172 SNRPA1 GeneProduct ncbigene:6627 ensembl:ENSG00000131876 ncbigene:6627 hgnc.symbol:SNRPA1 uniprot:P09661;uniprot:H0YKK0;uniprot:H0YLR3;uniprot:H0YMA0 RBM17 GeneProduct ncbigene:84991 ensembl:ENSG00000134453 ncbigene:84991 hgnc.symbol:RBM17 uniprot:Q5W011;uniprot:Q5W012;uniprot:Q5W010;uniprot:Q96I25;uniprot:Q5W009;uniprot:H0Y6J6 SNRPD3 GeneProduct ncbigene:6634 ensembl:ENSG00000100028 ncbigene:6634 hgnc.symbol:SNRPD3 uniprot:P62318 NCBP2 GeneProduct ncbigene:22916 ensembl:ENSG00000114503 ncbigene:22916 hgnc.symbol:NCBP2 uniprot:C9JQX9;uniprot:B3KSB0;uniprot:C9JKF4;uniprot:P52298;uniprot:F8WE41 DNAJC8 GeneProduct ncbigene:22826 ensembl:ENSG00000126698 ncbigene:22826 hgnc.symbol:DNAJC8 uniprot:S4R3J5;uniprot:O75937 RNGTT GeneProduct ncbigene:8732 ensembl:ENSG00000111880 ncbigene:8732 hgnc.symbol:RNGTT uniprot:O60942 SNRPD1 GeneProduct ncbigene:6632 ensembl:ENSG00000167088 ncbigene:6632 hgnc.symbol:SNRPD1 uniprot:J3QLR7;uniprot:J3QLI9;uniprot:P62314 SF3A2 GeneProduct ncbigene:8175 ensembl:ENSG00000104897 ncbigene:8175 hgnc.symbol:SF3A2 uniprot:Q15428;uniprot:K7EMT0 SNRPD2 GeneProduct ncbigene:6633 ensembl:ENSG00000125743 ncbigene:6633 hgnc.symbol:SNRPD2 uniprot:K7ERG4;uniprot:K7EJB5;uniprot:P62316 XRN2 GeneProduct ncbigene:22803 ensembl:ENSG00000088930 ncbigene:22803 hgnc.symbol:XRN2 uniprot:Q9H0D6 DHX16 GeneProduct ncbigene:8449 ensembl:ENSG00000204560 ncbigene:8449 hgnc.symbol:DHX16 uniprot:Q5SQH4;uniprot:Q5SQH5;uniprot:O60231;uniprot:A2AB15 HNRPM GeneProduct ncbigene:4670 ensembl:ENSG00000099783 ncbigene:4670 hgnc.symbol:HNRNPM uniprot:M0QYQ7;uniprot:M0R2I7;uniprot:M0QYL3;uniprot:M0QY96;uniprot:P52272;uniprot:M0R0N3;uniprot:M0R019;uniprot:M0R2T0;uniprot:A0A087X0X3;uniprot:M0QZM1;uniprot:M0R0Y6 HNRPA1 GeneProduct ncbigene:3178 ensembl:ENSG00000135486 ncbigene:3178 hgnc.symbol:HNRNPA1 uniprot:F8VTQ5;uniprot:F8W646;uniprot:A0A024RAZ7;uniprot:H0YH80;uniprot:A0A024RB53;uniprot:F8VYN5;uniprot:F8VZ49;uniprot:F8W6I7;uniprot:P09651 CUGBP2 GeneProduct ncbigene:10659 ensembl:ENSG00000048740 ncbigene:10659 hgnc.symbol:CELF2 uniprot:V9GYD9;uniprot:O95319;uniprot:A0A1B0GU44;uniprot:A0A0J9YXJ0;uniprot:A0A0J9YXK1;uniprot:A0A1B0GUN8;uniprot:E9PC62;uniprot:A0A0J9YX66;uniprot:Q5VZZ6;uniprot:V9GY47 SPOP GeneProduct ncbigene:8405 ensembl:ENSG00000121067 ncbigene:8405 hgnc.symbol:SPOP uniprot:D6RD94;uniprot:A0A590UJA7;uniprot:O43791;uniprot:D6RIS7;uniprot:D6RA79;uniprot:D6RBR3;uniprot:H0Y977;uniprot:D6RFL7;uniprot:D6RGZ4;uniprot:D6RDG8 HNRPA2B1 GeneProduct ncbigene:3181 ensembl:ENSG00000122566 ncbigene:3181 hgnc.symbol:HNRNPA2B1 uniprot:A0A087WUI2;uniprot:P22626;uniprot:A0A024RA28 PHF5A GeneProduct ncbigene:84844 ensembl:ENSG00000100410 ncbigene:84844 hgnc.symbol:PHF5A uniprot:A0A024R1U2;uniprot:Q7RTV0 SF3B5 GeneProduct ncbigene:83443 ensembl:ENSG00000169976 ncbigene:83443 hgnc.symbol:SF3B5 uniprot:Q9BWJ5 HNRPR GeneProduct ncbigene:10236 ensembl:ENSG00000125944 ncbigene:10236 hgnc.symbol:HNRNPR uniprot:A0A6Q8PHG0;uniprot:A0A6Q8PEX7;uniprot:A0A286YEZ8;uniprot:B4DT28;uniprot:A0A6Q8PH31;uniprot:O43390;uniprot:A0A6Q8PH35 C20orf14 GeneProduct ncbigene:24148 ensembl:ENSG00000101161 ncbigene:24148 hgnc.symbol:PRPF6 uniprot:O94906 NSEP1 GeneProduct ncbigene:4904 ensembl:ENSG00000065978 ncbigene:4904 hgnc.symbol:YBX1 uniprot:P67809;uniprot:H0Y449;uniprot:C9J5V9 SFRS9 GeneProduct ncbigene:8683 PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing) ensembl:ENSG00000111786 ncbigene:8683 hgnc.symbol:SRSF9 uniprot:S4R3G0;uniprot:H0YIB4;uniprot:Q13242 SF4 GeneProduct ncbigene:57794 inferred from: SURP 2, G patch protein, UniProt:O60378 ensembl:ENSG00000105705 ncbigene:57794 hgnc.symbol:SUGP1 uniprot:K7ELR6;uniprot:Q8IWZ8;uniprot:B4DVK3;uniprot:V9GZ08;uniprot:K7EM86;uniprot:K7ESM0;uniprot:K7ES12 SSFA1 GeneProduct ncbigene:4809 ensembl:ENSG00000100138 ncbigene:4809 hgnc.symbol:SNU13 uniprot:A0A3B3IRU2;uniprot:B1AHD1;uniprot:A0A3B3ISH1;uniprot:A0A3B3ISK4;uniprot:P55769;uniprot:A0A3B3IUA2;uniprot:A0A3B3ISH9;uniprot:Q6FHM6 SF3B3 GeneProduct ncbigene:23450 ensembl:ENSG00000189091 ncbigene:23450 hgnc.symbol:SF3B3 uniprot:Q15393;uniprot:I3L4G7;uniprot:J3QRB2;uniprot:J3QL37;uniprot:H3BMB0;uniprot:J3QKV4 FNBP3 GeneProduct ncbigene:55660 ensembl:ENSG00000196504 ncbigene:55660 hgnc.symbol:PRPF40A uniprot:H7C2N3;uniprot:H0YG38;uniprot:H7BXZ7;uniprot:O75400;uniprot:F5H578 PSKH1 GeneProduct ncbigene:5681 PMID: 12466556 ensembl:ENSG00000159792 ncbigene:5681 hgnc.symbol:PSKH1 uniprot:A0A087WZT9;uniprot:P11801 SNRPB2 GeneProduct ncbigene:6629 ensembl:ENSG00000125870 ncbigene:6629 hgnc.symbol:SNRPB2 uniprot:P08579 HNRPH2 GeneProduct ncbigene:3188 ensembl:ENSG00000126945 ncbigene:3188 hgnc.symbol:HNRNPH2 uniprot:A0A384MDT2;uniprot:P55795 WDR57 GeneProduct ncbigene:9410 ensembl:ENSG00000060688 ncbigene:9410 hgnc.symbol:SNRNP40 uniprot:Q9NSS8;uniprot:A0MNP2;uniprot:Q96DI7 HNRPU GeneProduct ncbigene:3192 ensembl:ENSG00000153187 ncbigene:3192 hgnc.symbol:HNRNPU uniprot:A0A1W2PPS1;uniprot:A0A1W2PQ74;uniprot:A0A1W2PPE9;uniprot:A0A087WVI9;uniprot:Q00839;uniprot:A0A1X7SBS1;uniprot:A0A1W2PPH7;uniprot:A0A1W2PRI6;uniprot:A0A087WZF3;uniprot:A0A1W2PQD4;uniprot:A0A1W2PPL4;uniprot:A0A1W2PNG3;uniprot:A0A1W2PQL0;uniprot:A0A1W2PP22;uniprot:A0A1W2PRZ7;uniprot:Q5RI18;uniprot:A0A1W2PP35;uniprot:A0A1W2PP34 PCBP2 GeneProduct ncbigene:5094 ensembl:ENSG00000197111 ncbigene:5094 hgnc.symbol:PCBP2 uniprot:H3BSS4;uniprot:H3BSP4;uniprot:F8W0G4;uniprot:F8VRH0;uniprot:F8VTZ0;uniprot:H3BND9;uniprot:H3BRU6;uniprot:F8VXH9;uniprot:F8W1G6;uniprot:Q15366;uniprot:F8VZX2;uniprot:A0A384N6B9 LSM7 GeneProduct ncbigene:51690 ensembl:ENSG00000130332 ncbigene:51690 hgnc.symbol:LSM7 uniprot:A0A087X2I5;uniprot:K7ENY5;uniprot:K7EML7;uniprot:Q9UK45 DDX1 GeneProduct ncbigene:1653 ensembl:ENSG00000079785 ncbigene:1653 hgnc.symbol:DDX1 uniprot:A3RJH1;uniprot:A0A087X2G1;uniprot:F1T0B3;uniprot:C9JLP0;uniprot:Q92499 SRPK1 GeneProduct ncbigene:6732 PMID: 12773558 ensembl:ENSG00000096063 ncbigene:6732 hgnc.symbol:SRPK1 uniprot:D6RBM8;uniprot:D6RDZ3;uniprot:D6RBF8;uniprot:H3BLV9;uniprot:D6RB98;uniprot:H0Y932;uniprot:Q96SB4 U2AF1 GeneProduct ncbigene:7307 ensembl:ENSG00000160201 ncbigene:7307 hgnc.symbol:U2AF1 uniprot:Q01081;uniprot:A0A1B0GW87 SFRS10 GeneProduct ncbigene:6434 ensembl:ENSG00000136527 ncbigene:6434 hgnc.symbol:TRA2B uniprot:H7C2L4;uniprot:H7BXF3;uniprot:P62995 SRPK2 GeneProduct ncbigene:6733 PMID: 12773558 ensembl:ENSG00000135250 ncbigene:6733 hgnc.symbol:SRPK2 uniprot:A0A024R704;uniprot:F8WAV6;uniprot:C9J2M4;uniprot:H7C521;uniprot:F8WBW4;uniprot:P78362;uniprot:H7C5L6;uniprot:C9JWF7 HNRPA3P1 GeneProduct ncbigene:10151 HNRPK GeneProduct ncbigene:3190 ensembl:ENSG00000165119 ncbigene:3190 hgnc.symbol:HNRNPK uniprot:P61978;uniprot:S4R457;uniprot:Q5T6W2;uniprot:S4R359 SSFA1 GeneProduct ncbigene:4809 ensembl:ENSG00000100138 ncbigene:4809 hgnc.symbol:SNU13 uniprot:A0A3B3IRU2;uniprot:B1AHD1;uniprot:A0A3B3ISH1;uniprot:A0A3B3ISK4;uniprot:P55769;uniprot:A0A3B3IUA2;uniprot:A0A3B3ISH9;uniprot:Q6FHM6 SUPT5H GeneProduct ncbigene:6829 ensembl:ENSG00000196235 ncbigene:6829 hgnc.symbol:SUPT5H uniprot:M0R105;uniprot:M0QYL9;uniprot:M0R2M5;uniprot:O00267 SRP54 GeneProduct ncbigene:6729 PMID: 14729963 ensembl:ENSG00000100883 ncbigene:6729 hgnc.symbol:SRP54 uniprot:G3V480;uniprot:P61011;uniprot:G3V3L9;uniprot:G3V346;uniprot:G3V4F7 PRPF4B GeneProduct ncbigene:8899 ensembl:ENSG00000112739 ncbigene:8899 hgnc.symbol:PRPF4B uniprot:H0YDJ3;uniprot:Q13523;uniprot:A0A024QZY5 CUGBP1 GeneProduct ncbigene:10658 ensembl:ENSG00000149187 ncbigene:10658 hgnc.symbol:CELF1 uniprot:E9PKU1;uniprot:G5EA30;uniprot:E9PKA1;uniprot:E9PSH0;uniprot:F5H3J7;uniprot:F5H4Y5;uniprot:F5H7M7;uniprot:E9PQK4;uniprot:F5H0D8;uniprot:Q92879 SFRS1 GeneProduct ncbigene:6426 Antagonist splicing factor ensembl:ENSG00000136450 ncbigene:6426 hgnc.symbol:SRSF1 uniprot:J3QQV5;uniprot:Q07955;uniprot:J3KSW7;uniprot:J3KTL2;uniprot:J3KSR8 HEAB GeneProduct ncbigene:10978 ensembl:ENSG00000172409 ncbigene:10978 hgnc.symbol:CLP1 uniprot:E9PKV5;uniprot:Q92989;uniprot:E9PJM4;uniprot:E9PL17 SNRPF GeneProduct ncbigene:6636 ensembl:ENSG00000139343 ncbigene:6636 hgnc.symbol:SNRPF uniprot:A0A0B4J254;uniprot:F8W0W6;uniprot:P62306 METTL3 GeneProduct ncbigene:56339 ensembl:ENSG00000165819 ncbigene:56339 hgnc.symbol:METTL3 uniprot:A0A0G2JH39;uniprot:F5H6D8;uniprot:B4DTN4;uniprot:H0YFV6;uniprot:B4E349;uniprot:Q86U44 SFRS6 GeneProduct ncbigene:6431 ensembl:ENSG00000124193 ncbigene:6431 hgnc.symbol:SRSF6 uniprot:A0A590UK01;uniprot:Q13247;uniprot:A0A590UJK4;uniprot:A0A590UJP7 NXF1 GeneProduct ncbigene:10482 ensembl:ENSG00000162231 ncbigene:10482 hgnc.symbol:NXF1 uniprot:H0YDU0;uniprot:E9PIN3;uniprot:E9PMV7;uniprot:B4E227;uniprot:E9PQA4;uniprot:Q9UBU9;uniprot:E9PLA7 SF3B2 GeneProduct ncbigene:10992 ensembl:ENSG00000087365 ncbigene:10992 hgnc.symbol:SF3B2 uniprot:E9PIL8;uniprot:E9PPJ0;uniprot:E9PJT3;uniprot:H0YCG1;uniprot:Q13435;uniprot:E9PJ04;uniprot:H0YEX5 SFPQ GeneProduct ncbigene:6421 ensembl:ENSG00000116560 ncbigene:6421 hgnc.symbol:SFPQ uniprot:A0A384N5Z8;uniprot:H0Y9U2;uniprot:P23246;uniprot:H0Y9K7 RBM5 GeneProduct ncbigene:10181 ensembl:ENSG00000003756 ncbigene:10181 hgnc.symbol:RBM5 uniprot:E1CJT4;uniprot:F8W910;uniprot:C9JR02;uniprot:F8WE23;uniprot:P52756;uniprot:C9J9P7;uniprot:H7BYM9;uniprot:A0A024R2U6;uniprot:C9JFQ5 PRPF3 GeneProduct ncbigene:9129 ensembl:ENSG00000117360 ncbigene:9129 hgnc.symbol:PRPF3 uniprot:O43395 SSFA1 GeneProduct ncbigene:4809 ensembl:ENSG00000100138 ncbigene:4809 hgnc.symbol:SNU13 uniprot:A0A3B3IRU2;uniprot:B1AHD1;uniprot:A0A3B3ISH1;uniprot:A0A3B3ISK4;uniprot:P55769;uniprot:A0A3B3IUA2;uniprot:A0A3B3ISH9;uniprot:Q6FHM6 FUSIP1 GeneProduct ncbigene:10772 FUSI MOUSE PMID: 11684676 ensembl:ENSG00000188529 ncbigene:10772 hgnc.symbol:SRSF10 uniprot:O75494;uniprot:R4GMP8;uniprot:A0A0S2Z504;uniprot:Q5JRI1;uniprot:Q6IQ42 CSTF3 GeneProduct ncbigene:1479 ensembl:ENSG00000176102 ncbigene:1479 hgnc.symbol:CSTF3 uniprot:E9PNK2;uniprot:Q12996;uniprot:E9PJ06;uniprot:E9PLP8;uniprot:H0YE74 PAPOLA GeneProduct ncbigene:10914 ensembl:ENSG00000090060 ncbigene:10914 hgnc.symbol:PAPOLA uniprot:G3XAH6;uniprot:A0A024R6M3;uniprot:A0A0C4DGK1;uniprot:H0YJ00;uniprot:G3V3I9;uniprot:G3V457;uniprot:H0YJL4;uniprot:P51003 HNRPD GeneProduct ncbigene:3184 ensembl:ENSG00000138668 ncbigene:3184 hgnc.symbol:HNRNPD uniprot:D6RBP9;uniprot:H0YA96;uniprot:D6RBQ9;uniprot:D6RD83;uniprot:A0A024RDF4;uniprot:A1LU37;uniprot:D6RAF8;uniprot:H0Y8G5;uniprot:Q14103;uniprot:A0A024RDB4;uniprot:D6RF44 CPSF3 GeneProduct ncbigene:51692 ensembl:ENSG00000119203 ncbigene:51692 hgnc.symbol:CPSF3 uniprot:G5E9W3;uniprot:Q9UKF6;uniprot:C9JZH6 HNRPAB GeneProduct ncbigene:3182 ensembl:ENSG00000197451 ncbigene:3182 hgnc.symbol:HNRNPAB uniprot:D6R9P3;uniprot:D6RD18;uniprot:Q99729;uniprot:D6RBZ0 SFRS16 GeneProduct ncbigene:11129 ensembl:ENSG00000104859 ncbigene:11129 hgnc.symbol:CLASRP uniprot:K7EP11;uniprot:Q8N2M8;uniprot:K7EKC9;uniprot:K7EKR8;uniprot:K7EM61;uniprot:A0A0A0MQS2;uniprot:F5H0Q6 POLR2A GeneProduct ncbigene:5430 ensembl:ENSG00000181222 ncbigene:5430 hgnc.symbol:POLR2A uniprot:A0A6Q8PGB0 DICER1 GeneProduct ncbigene:23405 ensembl:ENSG00000100697 ncbigene:23405 hgnc.symbol:DICER1 uniprot:A0A6Q8PFV4;uniprot:A0A6Q8PH99;uniprot:F6SZ09;uniprot:H0YJZ6;uniprot:A0A6Q8PHG6;uniprot:Q9UPY3;uniprot:Q5D0K5 PABPN1 GeneProduct ncbigene:8106 ensembl:ENSG00000100836 ncbigene:8106 hgnc.symbol:PABPN1 uniprot:H0YJH9;uniprot:G3V4T2;uniprot:Q86U42;uniprot:B4DEH8 RNU2 GeneProduct ncbigene:6066 GenBank sequence: K00027 ensembl:ENSG00000274585 ncbigene:6066 hgnc.symbol:RNU2-1 HRMT1L2 GeneProduct ncbigene:3276 ensembl:ENSG00000126457 ncbigene:3276 hgnc.symbol:PRMT1 uniprot:E9PIX6;uniprot:E9PKG1;uniprot:E9PMZ2;uniprot:E9PNR9;uniprot:E9PIE2;uniprot:E9PMW9;uniprot:E9PQ98;uniprot:Q99873;uniprot:H0YDE4 CPSF4 GeneProduct ncbigene:10898 ensembl:ENSG00000160917 ncbigene:10898 hgnc.symbol:CPSF4 uniprot:H7C419;uniprot:H7C016;uniprot:F8WEL7;uniprot:B7Z7B0;uniprot:C9K0K2;uniprot:O95639;uniprot:C9JEV9 SFRS8 GeneProduct ncbigene:6433 ensembl:ENSG00000061936 ncbigene:6433 hgnc.symbol:SFSWAP uniprot:Q12872;uniprot:H0YFR9;uniprot:F5H1A5 SFRS3 GeneProduct ncbigene:6428 ensembl:ENSG00000112081 ncbigene:6428 hgnc.symbol:SRSF3 uniprot:A0A087X2D0;uniprot:P84103;uniprot:B2R6F3 SF3A1 GeneProduct ncbigene:10291 ensembl:ENSG00000099995 ncbigene:10291 hgnc.symbol:SF3A1 uniprot:A0A024R1K8;uniprot:H7C1L2;uniprot:Q15459;uniprot:F8WC79;uniprot:F8WB66 CD2BP2 GeneProduct ncbigene:10421 ensembl:ENSG00000169217 ncbigene:10421 hgnc.symbol:CD2BP2 uniprot:O95400;uniprot:A0A024QZC1 LSM2 GeneProduct ncbigene:57819 ensembl:ENSG00000204392 ncbigene:57819 hgnc.symbol:LSM2 uniprot:Q9Y333 FUSIP1 GeneProduct ncbigene:10772 ensembl:ENSG00000188529 ncbigene:10772 hgnc.symbol:SRSF10 uniprot:O75494;uniprot:R4GMP8;uniprot:A0A0S2Z504;uniprot:Q5JRI1;uniprot:Q6IQ42 TMP21 GeneProduct ncbigene:10972 ensembl:ENSG00000170348 ncbigene:10972 hgnc.symbol:TMED10 uniprot:G3V2K7;uniprot:A0A024R6I3;uniprot:P49755 CPSF2 GeneProduct ncbigene:53981 ensembl:ENSG00000165934 ncbigene:53981 hgnc.symbol:CPSF2 uniprot:A0A024R6H0;uniprot:Q9P2I0;uniprot:G3V5T3;uniprot:G3V3T7;uniprot:H0YJF4 CPSF1 GeneProduct ncbigene:29894 ensembl:ENSG00000071894 ncbigene:29894 hgnc.symbol:CPSF1 uniprot:A0A087X101;uniprot:A0A087WTV4;uniprot:Q10570;uniprot:E9PIM1 SFRS2 GeneProduct ncbigene:6427 ensembl:ENSG00000161547 ncbigene:6427 hgnc.symbol:SRSF2 uniprot:J3QL05;uniprot:J3KP15;uniprot:A0A024R8U5;uniprot:Q01130 PPM1G GeneProduct ncbigene:5496 PMID: 12773558 ensembl:ENSG00000115241 ncbigene:5496 hgnc.symbol:PPM1G uniprot:O15355;uniprot:Q6IAU5 NUDT21 GeneProduct ncbigene:11051 ensembl:ENSG00000167005 ncbigene:11051 hgnc.symbol:NUDT21 uniprot:O43809;uniprot:A0A024R6W2;uniprot:H3BV41;uniprot:H3BND3 SF3B4 GeneProduct ncbigene:10262 ensembl:ENSG00000143368 ncbigene:10262 hgnc.symbol:SF3B4 uniprot:Q15427;uniprot:Q5SZ64 CSTF2 GeneProduct ncbigene:1478 ensembl:ENSG00000101811 ncbigene:1478 hgnc.symbol:CSTF2 uniprot:P33240;uniprot:A0A0A0MT56;uniprot:E9PID8;uniprot:E7EWR4 DHX38 GeneProduct ncbigene:9785 ensembl:ENSG00000140829 ncbigene:9785 hgnc.symbol:DHX38 uniprot:H3BV01;uniprot:H3BQT9;uniprot:H3BMS7;uniprot:J3KRT1;uniprot:J3KTG2;uniprot:J3KSA8;uniprot:Q92620 HNRPC GeneProduct ncbigene:3183 ensembl:ENSG00000092199 ncbigene:3183 hgnc.symbol:HNRNPC uniprot:G3V251;uniprot:G3V4W0;uniprot:B2R5W2;uniprot:P07910;uniprot:G3V2Q1;uniprot:G3V2D6;uniprot:B4DSU6;uniprot:B4DY08;uniprot:G3V3K6;uniprot:G3V2H6;uniprot:G3V4M8;uniprot:G3V4C1;uniprot:G3V576;uniprot:G3V575;uniprot:G3V5X6;uniprot:G3V5V7;uniprot:G3V555 SFRS12 GeneProduct ncbigene:140890 PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection. ensembl:ENSG00000153914 ncbigene:140890 hgnc.symbol:SREK1 uniprot:E5RFV3;uniprot:A0A087WY03;uniprot:E5RJ76;uniprot:Q8WXA9;uniprot:E5RK30;uniprot:H0YC47 SFRS4 GeneProduct ncbigene:6429 ensembl:ENSG00000116350 ncbigene:6429 hgnc.symbol:SRSF4 uniprot:A0A0D9SGD2;uniprot:S4R2X6;uniprot:Q08170;uniprot:A0A0D9SEM4 CLK2 GeneProduct ncbigene:1196 ensembl:ENSG00000176444 ncbigene:1196 hgnc.symbol:CLK2 uniprot:P49760;uniprot:B1AVT0;uniprot:A8K7I0 PRPF8 GeneProduct ncbigene:10594 ensembl:ENSG00000174231 ncbigene:10594 hgnc.symbol:PRPF8 uniprot:I3L1T8;uniprot:Q6P2Q9;uniprot:I3L3Z8;uniprot:I3L0J9 SF3A3 GeneProduct ncbigene:10946 ensembl:ENSG00000183431 ncbigene:10946 hgnc.symbol:SF3A3 uniprot:Q12874 SNRPN GeneProduct ncbigene:6638 ensembl:ENSG00000128739 ncbigene:6638 hgnc.symbol:SNRPN uniprot:X5DP00;uniprot:J3KRY3;uniprot:P63162;uniprot:J3QLE5 CLK4 GeneProduct ncbigene:57396 ensembl:ENSG00000113240 ncbigene:57396 hgnc.symbol:CLK4 uniprot:Q68D95;uniprot:Q6P090;uniprot:E7ES88;uniprot:E7EWJ6;uniprot:B7ZL31;uniprot:Q9HAZ1;uniprot:A0A087WX74 SF3B1 GeneProduct ncbigene:23451 ensembl:ENSG00000115524 ncbigene:23451 hgnc.symbol:SF3B1 uniprot:B4DGZ4;uniprot:A0A494C1M2;uniprot:F8WC19;uniprot:O75533;uniprot:H7C341 PRPF4 GeneProduct ncbigene:9128 ensembl:ENSG00000136875 ncbigene:9128 hgnc.symbol:PRPF4 uniprot:Q5T1M7;uniprot:O43172 HRMT1L1 GeneProduct ncbigene:3275 ensembl:ENSG00000160310 ncbigene:3275 hgnc.symbol:PRMT2 uniprot:A0A087WYX1;uniprot:A0A0S2Z3N3;uniprot:A8MXR3;uniprot:H7C2H9;uniprot:P55345 DDX20 GeneProduct ncbigene:11218 ensembl:ENSG00000064703 ncbigene:11218 hgnc.symbol:DDX20 uniprot:Q9UHI6 NONO GeneProduct ncbigene:4841 ensembl:ENSG00000147140 ncbigene:4841 hgnc.symbol:NONO uniprot:C9J4X2;uniprot:C9JYS8;uniprot:H7C367;uniprot:A0A0S2Z4Z9;uniprot:C9JJ13;uniprot:Q15233;uniprot:C9IZL7 BRUNOL4 GeneProduct ncbigene:56853 ensembl:ENSG00000101489 ncbigene:56853 hgnc.symbol:CELF4 uniprot:K7EJD7;uniprot:K7ERH1;uniprot:M0QY66;uniprot:K7EJK3;uniprot:K7EJ26;uniprot:K7ENR2;uniprot:B4DHA8;uniprot:K7EQ97;uniprot:Q9BZC1;uniprot:A0A0A0MTT3;uniprot:A0A0C4DGR1;uniprot:K7EPX2;uniprot:M0R137;uniprot:K7EJW4 SFRS5 GeneProduct ncbigene:6430 ensembl:ENSG00000100650 ncbigene:6430 hgnc.symbol:SRSF5 uniprot:B4DJK0;uniprot:G3V5K8;uniprot:Q13243;uniprot:B4DUA4;uniprot:A0A024R6D8 PRPF18 GeneProduct ncbigene:8559 ensembl:ENSG00000165630 ncbigene:8559 hgnc.symbol:PRPF18 uniprot:Q5T9P7;uniprot:Q5T9P8;uniprot:Q99633 CSTF2T GeneProduct ncbigene:23283 ensembl:ENSG00000177613 ncbigene:23283 hgnc.symbol:CSTF2T uniprot:Q9H0L4 PTBP1 GeneProduct ncbigene:5725 ensembl:ENSG00000011304 ncbigene:5725 hgnc.symbol:PTBP1 uniprot:A0A6Q8PEX4;uniprot:P26599;uniprot:A0A0D9SF20;uniprot:K7ELW5;uniprot:K7EK45;uniprot:A0A0U1RRM4;uniprot:A0A087WUW5;uniprot:K7EKJ7;uniprot:K7ES59;uniprot:A0A087WTS6;uniprot:A0A087WU68;uniprot:A6NLN1 SNRPN GeneProduct ncbigene:6638 ensembl:ENSG00000128739 ncbigene:6638 hgnc.symbol:SNRPN uniprot:X5DP00;uniprot:J3KRY3;uniprot:P63162;uniprot:J3QLE5 CSTF1 GeneProduct ncbigene:1477 ensembl:ENSG00000101138 ncbigene:1477 hgnc.symbol:CSTF1 uniprot:A3KFI9;uniprot:Q05048;uniprot:A0A087WV92;uniprot:A0A0A0MSZ9 HNRPL GeneProduct ncbigene:3191 ensembl:ENSG00000104824 ncbigene:3191 hgnc.symbol:HNRNPL uniprot:A0A3B3ITJ4;uniprot:M0R1W6;uniprot:P14866;uniprot:M0QYL7;uniprot:M0QXS5;uniprot:B4DVF8 U2AF2 GeneProduct ncbigene:11338 ensembl:ENSG00000063244 ncbigene:11338 hgnc.symbol:U2AF2 uniprot:M0QYQ9;uniprot:P26368;uniprot:K7ENG2;uniprot:K7ELP8 SFRS7 GeneProduct ncbigene:6432 ensembl:ENSG00000115875 ncbigene:6432 hgnc.symbol:SRSF7 uniprot:C9JAB2;uniprot:Q16629;uniprot:H7BZZ6;uniprot:H7C1N1;uniprot:F8WEA1;uniprot:A0A0B4J1Z1 DHX9 GeneProduct ncbigene:1660 ensembl:ENSG00000135829 ncbigene:1660 hgnc.symbol:DHX9 uniprot:Q08211 SFRS14 GeneProduct ncbigene:10147 ensembl:ENSG00000064607 ncbigene:10147 hgnc.symbol:SUGP2 uniprot:M0R3F6;uniprot:M0R2Z9;uniprot:M0R216;uniprot:Q8IX01;uniprot:M0R1Y3;uniprot:M0R065;uniprot:M0R2Y3 SRRM1 GeneProduct ncbigene:10250 ensembl:ENSG00000133226 ncbigene:10250 hgnc.symbol:SRRM1 uniprot:M0R1E7;uniprot:M0R088;uniprot:Q8IYB3;uniprot:M0QXG5;uniprot:A9Z1X7;uniprot:E9PCT1;uniprot:A0A0S2Z4W1 RNMT GeneProduct ncbigene:8731 ensembl:ENSG00000101654 ncbigene:8731 hgnc.symbol:RNMT uniprot:K7ERH6;uniprot:O43148;uniprot:K7EP06;uniprot:K7EPP5 SNRPE GeneProduct ncbigene:6635 ensembl:ENSG00000182004 ncbigene:6635 hgnc.symbol:SNRPE uniprot:P62304;uniprot:A6NHK2 CDC40 GeneProduct ncbigene:51362 ensembl:ENSG00000168438 ncbigene:51362 hgnc.symbol:CDC40 uniprot:O60508;uniprot:Q5SRN1 SNRPG GeneProduct ncbigene:6637 ensembl:ENSG00000143977 ncbigene:6637 hgnc.symbol:SNRPG uniprot:Q49AN9;uniprot:P62308;uniprot:F5H013;uniprot:C9JVQ0 RBMX GeneProduct ncbigene:27316 ensembl:ENSG00000147274 ncbigene:27316 hgnc.symbol:RBMX uniprot:P38159;uniprot:H3BR27;uniprot:H3BUY5;uniprot:H3BNC1;uniprot:H0Y6E7;uniprot:H3BT71 SNRPB GeneProduct ncbigene:6628 ensembl:ENSG00000125835 ncbigene:6628 hgnc.symbol:SNRPB uniprot:P14678;uniprot:S4R3P3;uniprot:Q66K91 SMC1L1 GeneProduct ncbigene:8243 ensembl:ENSG00000072501 ncbigene:8243 hgnc.symbol:SMC1A uniprot:A0A384MR33;uniprot:V9GYN9;uniprot:A0A6Q8PHC3;uniprot:Q14683;uniprot:G8JLG1;uniprot:V9GY57 SNRP70 GeneProduct ncbigene:6625 ensembl:ENSG00000104852 ncbigene:6625 hgnc.symbol:SNRNP70 uniprot:A0A024QZD5;uniprot:P08621;uniprot:M0QYR1;uniprot:M0QX04 PRPF8 GeneProduct ncbigene:10594 ensembl:ENSG00000174231 ncbigene:10594 hgnc.symbol:PRPF8 uniprot:I3L1T8;uniprot:Q6P2Q9;uniprot:I3L3Z8;uniprot:I3L0J9 TXNL4A GeneProduct ncbigene:10907 ensembl:ENSG00000141759 ncbigene:10907 hgnc.symbol:TXNL4A uniprot:K7EMX5;uniprot:K7ES07;uniprot:K7EJU2;uniprot:K7ESL1;uniprot:P83876;uniprot:O14835;uniprot:K7EPA6 NCBP1 GeneProduct ncbigene:4686 ensembl:ENSG00000136937 ncbigene:4686 hgnc.symbol:NCBP1 uniprot:F2Z2T1;uniprot:A0A024R179;uniprot:Q09161;uniprot:X6R941 CDC40 GeneProduct ncbigene:51362 ensembl:ENSG00000168438 ncbigene:51362 hgnc.symbol:CDC40 uniprot:O60508;uniprot:Q5SRN1 DHX8 GeneProduct ncbigene:1659 ensembl:ENSG00000067596 ncbigene:1659 hgnc.symbol:DHX8 uniprot:K7EQH7;uniprot:K7END7;uniprot:K7EJH9;uniprot:Q14562;uniprot:F5H658 CLK1 GeneProduct ncbigene:1195 ensembl:ENSG00000013441 ncbigene:1195 hgnc.symbol:CLK1 uniprot:B8ZZR0;uniprot:A0A087WVK0;uniprot:F8WBF5;uniprot:P49759 CLK3 GeneProduct ncbigene:1198 ensembl:ENSG00000179335 ncbigene:1198 hgnc.symbol:CLK3 uniprot:P49761;uniprot:H3BRE4;uniprot:H3BNC8;uniprot:H3BRW2;uniprot:H3BVF8;uniprot:H3BRK0;uniprot:H3BQR7;uniprot:H3BRT8;uniprot:H3BTW9;uniprot:H3BNQ5;uniprot:H3BUL5;uniprot:H3BV35;uniprot:H3BQG1 PTBP2 GeneProduct ncbigene:58155 ensembl:ENSG00000117569 ncbigene:58155 hgnc.symbol:PTBP2 uniprot:A0A6Q8PEZ3;uniprot:B4DI28;uniprot:Q9UKA9;uniprot:A0A6Q8PFC0;uniprot:A0A6Q8PH82;uniprot:A0A6Q8PFE6;uniprot:A0A6Q8PH43;uniprot:A0A6Q8PFT8 U5-116KD GeneProduct ncbigene:9343 ensembl:ENSG00000108883 ncbigene:9343 hgnc.symbol:EFTUD2 uniprot:K7EP67;uniprot:K7ERJ5;uniprot:Q15029;uniprot:K7EJ74;uniprot:K7EIT3;uniprot:K7EIV5;uniprot:K7EQ26 LSM2 GeneProduct ncbigene:57819 ensembl:ENSG00000204392 ncbigene:57819 hgnc.symbol:LSM2 uniprot:Q9Y333 RNPC2 GeneProduct ncbigene:9584 ensembl:ENSG00000131051 ncbigene:9584 hgnc.symbol:RBM39 uniprot:G3XAC6;uniprot:A0A087X122;uniprot:Q14498;uniprot:H0Y6I9;uniprot:F2Z2Z5;uniprot:A0A0U1RQH7;uniprot:H0Y4X3;uniprot:F8WF24;uniprot:A0A384NQ03;uniprot:H7BZG3;uniprot:F2Z3E6;uniprot:A8MYG5;uniprot:A0A0U1RQW2;uniprot:Q5QP22;uniprot:F8WF73;uniprot:Q5QP23 SNRPA GeneProduct ncbigene:6626 ensembl:ENSG00000077312 ncbigene:6626 hgnc.symbol:SNRPA uniprot:M0R0G9;uniprot:M0QXK2;uniprot:P09012;uniprot:M0R221;uniprot:M0R268;uniprot:M0QZG7;uniprot:M0R2B8 HNRPH1 GeneProduct ncbigene:3187 ensembl:ENSG00000169045 ncbigene:3187 hgnc.symbol:HNRNPH1 uniprot:D6RF17;uniprot:E5RGH4;uniprot:G8JLB6;uniprot:P31943;uniprot:H0YB39;uniprot:E5RJ94;uniprot:A0A384MEJ3;uniprot:D6R9D3;uniprot:D6RDL0;uniprot:E5RGV0;uniprot:D6RIT2;uniprot:H0YBG7;uniprot:D6RFM3;uniprot:D6RJ04;uniprot:H0YBW2;uniprot:H0YBK1;uniprot:H0YAQ2;uniprot:E7EN40;uniprot:D6R9T0;uniprot:D6RIH9;uniprot:D6RIU0;uniprot:D6RDU3;uniprot:E7EQJ0;uniprot:E9PCY7;uniprot:H0YBD7;uniprot:D6RAM1;uniprot:D6RBM0 FUS GeneProduct ncbigene:2521 ensembl:ENSG00000089280 ncbigene:2521 hgnc.symbol:FUS uniprot:H3BPE7;uniprot:Q6IBQ5;uniprot:P35637;uniprot:H3BNZ4 RNPS1 GeneProduct ncbigene:10921 PMID: 14729963 ensembl:ENSG00000205937 ncbigene:10921 hgnc.symbol:RNPS1 uniprot:D3DU92;uniprot:H3BTC0;uniprot:H3BTV0;uniprot:H3BV80;uniprot:Q15287;uniprot:H3BTY0;uniprot:H3BMS0;uniprot:H3BP82;uniprot:H3BNU7;uniprot:H3BPG5;uniprot:H3BUG0;uniprot:H3BMM9;uniprot:H3BUL0;uniprot:H3BNI3;uniprot:H3BTR6;uniprot:H3BRK4 DHX15 GeneProduct ncbigene:1665 ensembl:ENSG00000109606 ncbigene:1665 hgnc.symbol:DHX15 uniprot:O43143