Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps 3-OMD Metabolite chebi:82913 "AKA 3-ortho-methyldopa (3-OMD)" wikidata:Q15410220 chebi:82913;chebi:133668 inchikey:PFDUUKDQEHURQC-ZETCQYMHSA-N pubchem.compound:9307;pubchem.compound:25273143 chemspider:8948 hmdb:HMDB0060747 Primapterin Metabolite wikidata:Q26261687 "" wikidata:Q26261687 chebi:74689 inchikey:LNXRKRFGNHXANN-UHFFFAOYSA-N pubchem.compound:135764911;pubchem.compound:5488923 chemspider:4590031 hmdb:HMDB0002263 q-BH2 Metabolite chebi:43120 "Dihydrobiopterin" wikidata:Q28529687;wikidata:Q27093537 chebi:43120;chebi:140754;chebi:20680 inchikey:ZHQJVZLJDXWFFX-UHFFFAOYSA-N;inchikey:ZHQJVZLJDXWFFX-RPDRRWSUSA-N pubchem.compound:135398653;pubchem.compound:133246;pubchem.compound:135476784;pubchem.compound:1879 chemspider:4573556;chemspider:21238088;chemspider:117564;chemspider:21238640;chemspider:21233482;chemspider:1808 hmdb:HMDB0002215 kegg.compound:C00268 BH4 Metabolite chebi:30436 "AKA tetrahydropterin, 5,6,7,8-tetrahydrobiopterin" wikidata:Q74232496 chebi:30436 PTP Metabolite chebi:136564 "6-pyruvoyl tetrahydropterin, 6PPH4" wikidata:Q64221167 chebi:136564 inchikey:WBJZXBUVECZHCE-SCSAIBSYSA-N pubchem.compound:135440065 SAM Metabolite chebi:15414 "Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM)." wikidata:Q56071634;wikidata:Q106314841 chebi:15414;chebi:59789 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-O pubchem.compound:34756;pubchem.compound:24762165 chemspider:21169292 hmdb:HMDB0001185 kegg.compound:C00019 Phe Metabolite chebi:17295 "" wikidata:Q72440822;wikidata:Q170545;wikidata:Q106345467 chebi:58095;chebi:17295 inchikey:COLNVLDHVKWLRT-QMMMGPOBSA-N pubchem.compound:6140;pubchem.compound:6925665 chemspider:5910 hmdb:HMDB0000159 kegg.compound:C00079 norepinephrine Metabolite chebi:33569 "" wikidata:Q27087994 chebi:33569 inchikey:SFLSHLFXELFNJZ-UHFFFAOYSA-N pubchem.compound:951 chemspider:926 Serotonin Metabolite chebi:28790 "" wikidata:Q167934 chebi:28790 inchikey:QZAYGJVTTNCVMB-UHFFFAOYSA-N pubchem.compound:5202 chemspider:5013 hmdb:HMDB0000259 kegg.compound:C00780 HO-BH4 Metabolite chebi:15642 "AKA pterin-4a-carbinolamine" wikidata:Q74417390 chebi:15642 inchikey:KJKIEFUPAPPGBC-XXKOCQOQSA-N pubchem.compound:135476770 chemspider:30792101 hmdb:HMDB0002281 kegg.compound:C15522 5-OH-Trp Metabolite chebi:58266 "" wikidata:Q106345490;wikidata:Q238544 chebi:58266;chebi:17780 inchikey:LDCYZAJDBXYCGN-VIFPVBQESA-N pubchem.compound:6971044;pubchem.compound:439280 chemspider:388413 hmdb:HMDB0000472 kegg.compound:C00643 Dopamine Metabolite wikidata:Q170304 "" wikidata:Q170304 chebi:18243 inchikey:VYFYYTLLBUKUHU-UHFFFAOYSA-N pubchem.compound:681 chemspider:661 hmdb:HMDB0000073 kegg.compound:C03758 HVA Metabolite wikidata:Q903566 "homovanillic acid" wikidata:Q903566 chebi:545959 inchikey:QRMZSPFSDQBLIX-UHFFFAOYSA-N pubchem.compound:1738 chemspider:1675 hmdb:HMDB0000118 kegg.compound:C05582 sepiapterin Metabolite wikidata:Q2271580 "" wikidata:Q2271580 chebi:16095 inchikey:VPVOXUSPXFPWBN-UHFFFAOYSA-N pubchem.compound:135433595 N-acetylserotonin Metabolite chebi:17697 "" wikidata:Q4847704 chebi:17697 inchikey:MVAWJSIDNICKHF-UHFFFAOYSA-N pubchem.compound:903 chemspider:879 hmdb:HMDB0001238 kegg.compound:C00978 Biopterin Metabolite wikidata:Q41793745 "" wikidata:Q41793745 chebi:41183 inchikey:LHQIJBMDNUYRAM-AWFVSMACSA-N pubchem.compound:135449517 hmdb:HMDB0000633 L-DOPA Metabolite wikidata:Q300989 "" wikidata:Q300989 chebi:15765;chebi:57504 inchikey:WTDRDQBEARUVNC-LURJTMIESA-N pubchem.compound:6047;pubchem.compound:6971033 chemspider:5824 hmdb:HMDB0000181 kegg.compound:C00355 NH2TP Metabolite chebi:58462 "aka 7,8-dihydroneopterin 3'-triphosphate, dihydroneopterin triphosphate, dihydroneopterin-PPP" wikidata:Q27125806 chebi:58462 inchikey:DGGUVLXVLHAAGT-XINAWCOVSA-J pubchem.compound:135398609;pubchem.compound:25201779 GTP Metabolite chebi:37565 "" wikidata:Q27117191 chebi:37565 inchikey:XKMLYUALXHKNFT-UUOKFMHZSA-J pubchem.compound:135398632;pubchem.compound:7058167 chemspider:5414499 5HIAA Metabolite hmdb:HMDB0000763 "5-hydroxyindoleacetic acid" chebi:27823 inchikey:DUUGKQCEGZLZNO-UHFFFAOYSA-N pubchem.compound:1826 chemspider:1760 hmdb:HMDB0000763 kegg.compound:C05635 oxo-PH4 Metabolite pubchem.compound:135398702 "AKA 6-lactoyltetrahydropterin (1′-oxoTHP) [PMID:1913029]." wikidata:Q27102282 chebi:17248 inchikey:HKCYZTKHPLJZDR-UHFFFAOYSA-N pubchem.compound:135398702 chemspider:148245 hmdb:HMDB0002065 kegg.compound:C04244 Phenyl-alanine Metabolite wikidata:Q170545 "" wikidata:Q170545 chebi:58095;chebi:17295 inchikey:COLNVLDHVKWLRT-QMMMGPOBSA-N pubchem.compound:6140;pubchem.compound:6925665 chemspider:5910 hmdb:HMDB0000159 kegg.compound:C00079 Neopterin Metabolite wikidata:Q908292 "" wikidata:Q908292 inchikey:BMQYVXCPAOLZOK-XINAWCOVSA-N pubchem.compound:135398721 chemspider:395518 kegg.compound:C05926 Trp Metabolite wikidata:Q181003 "" wikidata:Q181003 chebi:57912;chebi:16828 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N pubchem.compound:6305;pubchem.compound:6923516 chemspider:6066 hmdb:HMDB0000929 kegg.compound:C00078 7,8-BH2 Metabolite wikidata:Q5276421 "7,8-dihydrobiopterin" wikidata:Q5276421 chebi:64277 inchikey:FEMXZDUTFRTWPE-UHFFFAOYSA-N pubchem.compound:252;pubchem.compound:135402011 chemspider:247 hmdb:HMDB0247294 kegg.compound:C02953 NADPH Metabolite wikidata:Q26841327 "" wikidata:Q26841327 chebi:16474 inchikey:ACFIXJIJDZMPPO-NNYOXOHSSA-N pubchem.compound:5884 chemspider:5673 hmdb:HMDB0000221 kegg.compound:C00005 tyr Metabolite wikidata:Q188017 "" wikidata:Q188017 chebi:58315;chebi:17895 inchikey:OUYCCCASQSFEME-QMMMGPOBSA-N pubchem.compound:6057;pubchem.compound:6942100 chemspider:5833 hmdb:HMDB0000158 kegg.compound:C00082 O₂ Metabolite chebi:15379 "" wikidata:Q5203615 chebi:15379 inchikey:MYMOFIZGZYHOMD-UHFFFAOYSA-N pubchem.compound:977 chemspider:952 hmdb:HMDB0001377 kegg.compound:C00007 MHPG Metabolite chebi:1576 "AKA 3-methoxy-4-hydroxyphenylglycol" wikidata:Q223097 chebi:1576 inchikey:FBWPWWWZWKPJFL-UHFFFAOYSA-N pubchem.compound:10805 chemspider:10348 hmdb:HMDB0001490 kegg.compound:C05594 Epinephrine Metabolite hmdb:HMDB00068 "" wikidata:Q132621 chebi:28918 inchikey:UCTWMZQNUQWSLP-VIFPVBQESA-N pubchem.compound:139148732;pubchem.compound:5816 chemspider:5611 hmdb:HMDB0000068 kegg.compound:C00788 VMA Metabolite chebi:20106 "AKA Vanillylmandelic acid" wikidata:Q72484825;wikidata:Q901369 chebi:20106 inchikey:CGQCWMIAEPEHNQ-UHFFFAOYSA-N pubchem.compound:1245 chemspider:1207 hmdb:HMDB0000291 kegg.compound:C05584 melatonin Metabolite chebi:16796 "" wikidata:Q180912 chebi:16796 inchikey:DRLFMBDRBRZALE-UHFFFAOYSA-N pubchem.compound:896 chemspider:872 hmdb:HMDB0001389 kegg.compound:C01598 DHPR Protein uniprot:P09417 "dihydropteridine reductase" ensembl:ENSG00000151552 ncbigene:5860 hgnc.symbol:QDPR uniprot:B7Z415;uniprot:A0A140VKA9;uniprot:P09417;uniprot:H0Y8F7;uniprot:D6RGG7;uniprot:D6RHJ7 DHFR Protein uniprot:P00374 "dihydrofolate reductase" ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 SNA Protein uniprot:Q16613 "AKA serotonin N-acetylase; 'Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT); an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. ' Source: https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase]" ensembl:ENSG00000129673 ncbigene:15 hgnc.symbol:AANAT uniprot:Q16613;uniprot:F1T0I5;uniprot:K7ERF6;uniprot:K7ESH7 DBH Protein uniprot:P09172 "AKA dopamine β-hydroxylase" ensembl:ENSG00000123454 ncbigene:1621 hgnc.symbol:DBH uniprot:Q5T382;uniprot:P09172 GTPCH Protein uniprot:P30793 "aka GTP cyclohydrolase I" ensembl:ENSG00000131979 ncbigene:2643 hgnc.symbol:GCH1 uniprot:A0A024R642;uniprot:P30793 SR Protein uniprot:P35270 "sepiapterin reductase, gene SPR" ensembl:ENSG00000116096 ncbigene:6697 hgnc.symbol:SPR uniprot:P35270 PNMT Protein uniprot:P11086 "AKA phenylethanolamine-N-methyltransferase" ensembl:ENSG00000141744 ncbigene:5409 hgnc.symbol:PNMT uniprot:A8MT87;uniprot:J3QRI3;uniprot:P11086 CR Protein eccode:1.1.1.184 "AKA carbonyl reductase" PAH Protein uniprot:P00439 "AKA phenylalanine hydroxylase" ensembl:ENSG00000171759 ncbigene:5053 hgnc.symbol:PAH uniprot:A0A024RBG4;uniprot:J3KND8;uniprot:F8W1D4;uniprot:P00439;uniprot:A0A0U1RQI3;uniprot:F8W0A0;uniprot:A0A0U1RQY4 PTPS Protein uniprot:Q03393 "AKA 6-pyruvoyl-tetrahydropterin synthase" ensembl:ENSG00000150787 ncbigene:5805 hgnc.symbol:PTS uniprot:E9PKY8;uniprot:E9PJM0;uniprot:E9PNN3;uniprot:Q03393 TH Protein uniprot:P07101 "tyrosine hydroxylase" ensembl:ENSG00000180176 ncbigene:7054 hgnc.symbol:TH uniprot:H0Y670;uniprot:F8W8M5;uniprot:H0Y677;uniprot:E7EQI0;uniprot:P07101 MAO Protein eccode:1.4.3.4 "AKA monoamine oxidase" AR Protein eccode:1.1.1.21 "AKA aldose reductase" MAOA Protein uniprot:P21397 "'Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A.' Source: https://en.wikipedia.org/wiki/Monoamine_oxidase" ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:A0A8I5KP93;uniprot:Q53YE7;uniprot:A0A8I5KUC3;uniprot:P21397 TPH Protein eccode:1.14.16.4 "tryptophan hydroxylase" PCD Protein eccode:4.2.1.96 "AKA pterin-4a-carbinolamine dehydratase" CR Protein eccode:1.1.1.184 "carbonyl reductase, Wikidata:Q1145916" PAH Protein uniprot:P00439 "phenylalanine-4-hydroxylase" ensembl:ENSG00000171759 ncbigene:5053 hgnc.symbol:PAH uniprot:A0A024RBG4;uniprot:J3KND8;uniprot:F8W1D4;uniprot:P00439;uniprot:A0A0U1RQI3;uniprot:F8W0A0;uniprot:A0A0U1RQY4 COMT Protein uniprot:P21964 "" ensembl:ENSG00000093010 ncbigene:1312 hgnc.symbol:COMT uniprot:H7BZ45;uniprot:A0A7I2V3G7;uniprot:E7EMS6;uniprot:P21964;uniprot:A0A7I2V370;uniprot:A0A140VJG8;uniprot:E7EUU8;uniprot:F8WBW9 ASMT Protein uniprot:P46597 "AKA hydroxyindole O-methyltransferase, HIOMT (deprecated alias), N-Acetylserotonin O-methyltransferase, also known as ASMT" ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 DNAJC12 Protein uniprot:Q9UKB3 "co-chaperone of PAH" ensembl:ENSG00000108176 ncbigene:56521 hgnc.symbol:DNAJC12 uniprot:S4R3W0;uniprot:Q6IAH1;uniprot:S4R3E2;uniprot:Q9UKB3;uniprot:S4R368 SR Protein uniprot:P35270 "sepiapterin reductase" ensembl:ENSG00000116096 ncbigene:6697 hgnc.symbol:SPR uniprot:P35270 DNAJC12 Protein uniprot:Q9UKB3 "'DNAJC12 interacts with PAH, TH, and the TPHs, which indicates that DNAJC12 is a specific co-­chaperone for the aromatic amino acid hydroxylases that contributes to the maintenance of their intracellular stability'" ensembl:ENSG00000108176 ncbigene:56521 hgnc.symbol:DNAJC12 uniprot:S4R3W0;uniprot:Q6IAH1;uniprot:S4R3E2;uniprot:Q9UKB3;uniprot:S4R368 AADC Protein eccode:4.1.1.28 "aromatic l-amino acid decarboxylase; Wikidata: Q421186" MAOB Protein uniprot:P27338 "'MAO-A and MAO-B were believed to metabolize dopamine, tyramine, and tryptamine; however, recent evidence suggests MAO-B may not be responsible for a significant amount of dopamine degradation.' Source: https://en.wikipedia.org/wiki/Monoamine_oxidase" ensembl:ENSG00000069535 ncbigene:4129 hgnc.symbol:MAOB uniprot:P27338