Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI 3-OMD Metabolite chebi:82913 "AKA 3-ortho-methyldopa (3-OMD)" wikidata:Q15410220 chebi:82913;chebi:82913 inchikey:PFDUUKDQEHURQC-ZETCQYMHSA-N Primapterin Metabolite wikidata:Q26261687 "" wikidata:Q26261687 chebi:74689;chebi:74689 inchikey:LNXRKRFGNHXANN-UHFFFAOYSA-N q-BH2 Metabolite chebi:43120 "Dihydrobiopterin" wikidata:Q27093537 chebi:43120;chebi:43120 inchikey:ZHQJVZLJDXWFFX-RPDRRWSUSA-N BH4 Metabolite chebi:30436 "AKA tetrahydropterin, 5,6,7,8-tetrahydrobiopterin" wikidata:Q74232496 chebi:30436;chebi:30436 PTP Metabolite chebi:136564 "6-pyruvoyl tetrahydropterin, 6PPH4" wikidata:Q64221167 chebi:136564;chebi:136564 inchikey:WBJZXBUVECZHCE-SCSAIBSYSA-N SAM Metabolite chebi:15414 "Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM)." wikidata:Q56071634 chebi:15414;chebi:15414 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-O Phe Metabolite chebi:28044 "" wikidata:Q27103475 chebi:28044;chebi:28044 inchikey:COLNVLDHVKWLRT-UHFFFAOYSA-N norepinephrine Metabolite chebi:33569 "" wikidata:Q27087994 chebi:33569;chebi:33569 inchikey:SFLSHLFXELFNJZ-UHFFFAOYSA-N Serotonin Metabolite chebi:28790 "" wikidata:Q167934 chebi:28790;chebi:28790 inchikey:QZAYGJVTTNCVMB-UHFFFAOYSA-N HO-BH4 Metabolite chebi:15642 "AKA pterin-4a-carbinolamine" wikidata:Q74417390 chebi:15642;chebi:15642 inchikey:KJKIEFUPAPPGBC-XXKOCQOQSA-N 5-OH-Trp Metabolite chebi:58266 "" wikidata:Q106345490 chebi:58266;chebi:58266 inchikey:LDCYZAJDBXYCGN-VIFPVBQESA-N Dopamine Metabolite wikidata:Q170304 "" wikidata:Q170304 chebi:18243;chebi:18243 inchikey:VYFYYTLLBUKUHU-UHFFFAOYSA-N HVA Metabolite wikidata:Q903566 "homovanillic acid" wikidata:Q903566 chebi:545959;chebi:545959 inchikey:QRMZSPFSDQBLIX-UHFFFAOYSA-N sepiapterin Metabolite wikidata:Q2271580 "" wikidata:Q2271580 chebi:16095;chebi:16095 inchikey:VPVOXUSPXFPWBN-UHFFFAOYSA-N N-acetylserotonin Metabolite chebi:17697 "" wikidata:Q4847704 chebi:17697;chebi:17697 inchikey:MVAWJSIDNICKHF-UHFFFAOYSA-N Biopterin Metabolite wikidata:Q41793745 "" wikidata:Q41793745 chebi:41183;chebi:41183 inchikey:LHQIJBMDNUYRAM-AWFVSMACSA-N L-DOPA Metabolite wikidata:Q300989 "" wikidata:Q300989 chebi:15765;chebi:15765 inchikey:WTDRDQBEARUVNC-LURJTMIESA-N NH2TP Metabolite chebi:58462 "aka 7,8-dihydroneopterin 3'-triphosphate, dihydroneopterin triphosphate, dihydroneopterin-PPP" wikidata:Q27125806 chebi:58462;chebi:58462 inchikey:DGGUVLXVLHAAGT-XINAWCOVSA-J GTP Metabolite chebi:37565 "" wikidata:Q27117191 chebi:37565;chebi:37565 inchikey:XKMLYUALXHKNFT-UUOKFMHZSA-J 5HIAA Metabolite hmdb:HMDB0000763 "5-hydroxyindoleacetic acid" chebi:27823;chebi:27823 inchikey:DUUGKQCEGZLZNO-UHFFFAOYSA-N oxo-PH4 Metabolite pubchem.compound:135398702 "AKA 6-lactoyltetrahydropterin (1′-oxoTHP) [PMID:1913029]." Phenyl-alanine Metabolite wikidata:Q170545 "" wikidata:Q170545 chebi:17295;chebi:17295 inchikey:COLNVLDHVKWLRT-QMMMGPOBSA-N Neopterin Metabolite wikidata:Q908292 "" wikidata:Q908292 inchikey:BMQYVXCPAOLZOK-XINAWCOVSA-N Trp Metabolite wikidata:Q181003 "" wikidata:Q181003 chebi:16828;chebi:16828 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N 7,8-BH2 Metabolite wikidata:Q5276421 "7,8-dihydrobiopterin" wikidata:Q5276421 chebi:64277;chebi:64277 inchikey:FEMXZDUTFRTWPE-UHFFFAOYSA-N NADPH Metabolite wikidata:Q26841327 "" wikidata:Q26841327 chebi:16474;chebi:16474 inchikey:ACFIXJIJDZMPPO-NNYOXOHSSA-N tyr Metabolite wikidata:Q188017 "" wikidata:Q188017 chebi:17895;chebi:17895 inchikey:OUYCCCASQSFEME-QMMMGPOBSA-N O2 Metabolite chebi:15379 "" wikidata:Q5203615 chebi:15379;chebi:15379 inchikey:MYMOFIZGZYHOMD-UHFFFAOYSA-N O2 Metabolite chebi:15379 "" wikidata:Q5203615 chebi:15379;chebi:15379 inchikey:MYMOFIZGZYHOMD-UHFFFAOYSA-N MHPG Metabolite chebi:1576 "AKA 3-methoxy-4-hydroxyphenylglycol" wikidata:Q223097 chebi:1576;chebi:1576 inchikey:FBWPWWWZWKPJFL-UHFFFAOYSA-N Epinephrine Metabolite hmdb:HMDB00068 "" wikidata:Q132621 chebi:28918;chebi:28918 inchikey:UCTWMZQNUQWSLP-VIFPVBQESA-N VMA Metabolite chebi:20106 "AKA Vanillylmandelic acid" wikidata:Q901369 chebi:20106;chebi:20106 inchikey:CGQCWMIAEPEHNQ-UHFFFAOYSA-N SAM Metabolite chebi:15414 "Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM)." wikidata:Q56071634 chebi:15414;chebi:15414 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-O melatonin Metabolite chebi:16796 "" wikidata:Q180912 chebi:16796;chebi:16796 inchikey:DRLFMBDRBRZALE-UHFFFAOYSA-N DHPR Protein uniprot:P09417 "dihydropteridine reductase" ensembl:ENSG00000151552 ncbigene:5860 hgnc.symbol:QDPR uniprot:B7Z415;uniprot:A0A140VKA9;uniprot:P09417;uniprot:H0Y8F7;uniprot:D6RGG7;uniprot:D6RHJ7 DHFR Protein uniprot:P00374 "dihydrofolate reductase" ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 SNA Protein uniprot:Q16613 "AKA serotonin N-acetylase; 'Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT); an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. ' Source: https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase]" ensembl:ENSG00000129673 ncbigene:15 hgnc.symbol:AANAT uniprot:Q16613;uniprot:F1T0I5;uniprot:K7ERF6;uniprot:K7ESH7 DBH Protein uniprot:P09172 "AKA dopamine β-hydroxylase" ensembl:ENSG00000123454 ncbigene:1621 hgnc.symbol:DBH uniprot:Q5T382;uniprot:P09172 GTPCH Protein uniprot:P30793 "aka GTP cyclohydrolase I" ensembl:ENSG00000131979 ncbigene:2643 hgnc.symbol:GCH1 uniprot:A0A024R642;uniprot:P30793 SR Protein uniprot:P35270 "sepiapterin reductase, gene SPR" ensembl:ENSG00000116096 ncbigene:6697 hgnc.symbol:SPR uniprot:P35270 PNMT Protein uniprot:P11086 "AKA phenylethanolamine-N-methyltransferase" ensembl:ENSG00000141744 ncbigene:5409 hgnc.symbol:PNMT uniprot:A8MT87;uniprot:J3QRI3;uniprot:P11086 CR Protein eccode:1.1.1.184 "AKA carbonyl reductase" PAH Protein uniprot:P00439 "AKA phenylalanine hydroxylase" ensembl:ENSG00000171759 ncbigene:5053 hgnc.symbol:PAH uniprot:A0A024RBG4;uniprot:J3KND8;uniprot:F8W1D4;uniprot:P00439;uniprot:A0A0U1RQI3;uniprot:F8W0A0;uniprot:A0A0U1RQY4 PTPS Protein uniprot:Q03393 "AKA 6-pyruvoyl-tetrahydropterin synthase" ensembl:ENSG00000150787 ncbigene:5805 hgnc.symbol:PTS uniprot:E9PKY8;uniprot:E9PJM0;uniprot:E9PNN3;uniprot:Q03393 TH Protein uniprot:P07101 "tyrosine hydroxylase" ensembl:ENSG00000180176 ncbigene:7054 hgnc.symbol:TH uniprot:H0Y670;uniprot:F8W8M5;uniprot:H0Y677;uniprot:E7EQI0;uniprot:P07101 MAO Protein eccode:1.4.3.4 "AKA monoamine oxidase" AR Protein eccode:1.1.1.21 "AKA aldose reductase" MAOA Protein uniprot:P21397 "'Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A.' Source: https://en.wikipedia.org/wiki/Monoamine_oxidase" ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 TPH Protein eccode:1.14.16.4 "tryptophan hydroxylase" PCD Protein eccode:4.2.1.96 "AKA pterin-4a-carbinolamine dehydratase" CR Protein eccode:1.1.1.184 "carbonyl reductase, Wikidata:Q1145916" PAH Protein uniprot:P00439 "phenylalanine-4-hydroxylase" ensembl:ENSG00000171759 ncbigene:5053 hgnc.symbol:PAH uniprot:A0A024RBG4;uniprot:J3KND8;uniprot:F8W1D4;uniprot:P00439;uniprot:A0A0U1RQI3;uniprot:F8W0A0;uniprot:A0A0U1RQY4 COMT Protein uniprot:P21964 "" ensembl:ENSG00000093010 ncbigene:1312 hgnc.symbol:COMT uniprot:H7BZ45;uniprot:A0A7I2V3G7;uniprot:E7EMS6;uniprot:P21964;uniprot:A0A7I2V370;uniprot:A0A140VJG8;uniprot:E7EUU8;uniprot:F8WBW9 ASMT Protein uniprot:P46597 "AKA hydroxyindole O-methyltransferase, HIOMT (deprecated alias), N-Acetylserotonin O-methyltransferase, also known as ASMT" ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 DNAJC12 Protein uniprot:Q9UKB3 "co-chaperone of PAH" ensembl:ENSG00000108176 ncbigene:56521 hgnc.symbol:DNAJC12 uniprot:S4R3W0;uniprot:Q6IAH1;uniprot:S4R3E2;uniprot:Q9UKB3;uniprot:S4R368 SR Protein uniprot:P35270 "sepiapterin reductase" ensembl:ENSG00000116096 ncbigene:6697 hgnc.symbol:SPR uniprot:P35270 DNAJC12 Protein uniprot:Q9UKB3 "'DNAJC12 interacts with PAH, TH, and the TPHs, which indicates that DNAJC12 is a specific co-­chaperone for the aromatic amino acid hydroxylases that contributes to the maintenance of their intracellular stability'" ensembl:ENSG00000108176 ncbigene:56521 hgnc.symbol:DNAJC12 uniprot:S4R3W0;uniprot:Q6IAH1;uniprot:S4R3E2;uniprot:Q9UKB3;uniprot:S4R368 CR Protein eccode:1.1.1.184 "AKA carbonyl reductase" AR Protein eccode:1.1.1.21 "AKA aldose reductase" AADC Protein eccode:4.1.1.28 "aromatic l-amino acid decarboxylase; Wikidata: Q421186" MAO Protein eccode:1.4.3.4 "AKA monoamine oxidase" MAOA Protein uniprot:P21397 "'Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A.' Source: https://en.wikipedia.org/wiki/Monoamine_oxidase" ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 MAOB Protein uniprot:P27338 "'MAO-A and MAO-B were believed to metabolize dopamine, tyramine, and tryptamine; however, recent evidence suggests MAO-B may not be responsible for a significant amount of dopamine degradation.' Source: https://en.wikipedia.org/wiki/Monoamine_oxidase" ensembl:ENSG00000069535 ncbigene:4129 hgnc.symbol:MAOB uniprot:P27338 COMT Protein uniprot:P21964 "" ensembl:ENSG00000093010 ncbigene:1312 hgnc.symbol:COMT uniprot:H7BZ45;uniprot:A0A7I2V3G7;uniprot:E7EMS6;uniprot:P21964;uniprot:A0A7I2V370;uniprot:A0A140VJG8;uniprot:E7EUU8;uniprot:F8WBW9