Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps melatonin Metabolite chebi:16796 "" wikidata:Q180912 chebi:16796 inchikey:DRLFMBDRBRZALE-UHFFFAOYSA-N pubchem.compound:896 chemspider:872 hmdb:HMDB0001389 kegg.compound:C01598 Dihydroxyphenylacetic acid Metabolite chebi:41941 "AKA DOPAC" wikidata:Q4634071 chebi:41941 inchikey:CFFZDZCDUFSOFZ-UHFFFAOYSA-N pubchem.compound:547 chemspider:532 hmdb:HMDB0001336 kegg.compound:C01161 5-HIAL Metabolite pubchem.compound:74688 "AKA 5-hydroxyindoleacetaldehyde" wikidata:Q27073985 chebi:50157 inchikey:OBFAPCIUSYHFIE-UHFFFAOYSA-N pubchem.compound:74688 chemspider:67261 hmdb:HMDB0004073 kegg.compound:C05634 Vanillylmandelic acid Metabolite chebi:27622 "" wikidata:Q27103230 chebi:27622 inchikey:CGQCWMIAEPEHNQ-UHFFFAOYSA-M pubchem.compound:23615482 chemspider:19951553 hmdb:HMDB0304531 Epinephrine Metabolite wikidata:Q132621 "" wikidata:Q132621 chebi:28918 inchikey:UCTWMZQNUQWSLP-VIFPVBQESA-N pubchem.compound:139148732;pubchem.compound:5816 chemspider:5611 hmdb:HMDB0000068 kegg.compound:C00788 3-methoxy-4-hydroxyphenylglycol Metabolite wikidata:Q223097 "AKA MHPG, MOPG" wikidata:Q223097 chebi:1576 inchikey:FBWPWWWZWKPJFL-UHFFFAOYSA-N pubchem.compound:10805 chemspider:10348 hmdb:HMDB0001490 kegg.compound:C05594 Norepinephrine Metabolite chebi:72587 "" wikidata:Q27139997 chebi:72587 inchikey:SFLSHLFXELFNJZ-QMMMGPOBSA-O pubchem.compound:6921840 chemspider:5296731 Dopamine Metabolite chebi:59905 "" wikidata:Q27126955 chebi:59905 inchikey:VYFYYTLLBUKUHU-UHFFFAOYSA-O pubchem.compound:67114988;pubchem.compound:3713609 chemspider:2944843 L-Tyrosine Metabolite chebi:58315 "" wikidata:Q188017;wikidata:Q106345477 chebi:58315;chebi:17895 inchikey:OUYCCCASQSFEME-QMMMGPOBSA-N pubchem.compound:6057;pubchem.compound:6942100 chemspider:5833 hmdb:HMDB0000158 kegg.compound:C00082 Serotonin Metabolite chebi:28790 "" wikidata:Q167934 chebi:28790 inchikey:QZAYGJVTTNCVMB-UHFFFAOYSA-N pubchem.compound:5202 chemspider:5013 hmdb:HMDB0000259 kegg.compound:C00780 Normetanephrine Metabolite wikidata:Q517109 "" wikidata:Q517109 chebi:89951 inchikey:YNYAYWLBAHXHLL-UHFFFAOYSA-N pubchem.compound:1237 chemspider:1200 hmdb:HMDB0000819 Metanephrine Metabolite hmdb:HMDB0004063 "AKA MET" chebi:144365 inchikey:JWJCTZKFYGDABJ-UHFFFAOYSA-N pubchem.compound:21100 chemspider:19844 hmdb:HMDB0004063 kegg.compound:C05588 Vanillactic acid Metabolite hmdb:HMDB0000913 "AKA VLA" chebi:1240674 inchikey:SVYIZYRTOYHQRE-UHFFFAOYSA-N pubchem.compound:160637 chemspider:141152 hmdb:HMDB0000913 Homovanillic acid Metabolite chebi:545959 "AKA HVA" wikidata:Q903566 chebi:545959 inchikey:QRMZSPFSDQBLIX-UHFFFAOYSA-N pubchem.compound:1738 chemspider:1675 hmdb:HMDB0000118 kegg.compound:C05582 L-Tryptophan Metabolite chebi:16828 "" wikidata:Q106345470;wikidata:Q181003 chebi:57912;chebi:16828 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N pubchem.compound:6305;pubchem.compound:6923516 chemspider:6066 hmdb:HMDB0000929 kegg.compound:C00078 5-Hydroxytryptophan Metabolite chebi:17780 "AKA 5-HTP" wikidata:Q106345490;wikidata:Q238544 chebi:58266;chebi:17780 inchikey:LDCYZAJDBXYCGN-VIFPVBQESA-N pubchem.compound:6971044;pubchem.compound:439280 chemspider:388413 hmdb:HMDB0000472 kegg.compound:C00643 5-Hydroxyindoleacetic acid Metabolite chebi:27823 "AKA 5-HIAA" wikidata:Q238532 chebi:27823 inchikey:DUUGKQCEGZLZNO-UHFFFAOYSA-N pubchem.compound:1826 chemspider:1760 hmdb:HMDB0000763 kegg.compound:C05635 3-O-methyldopa Metabolite chebi:82913 "AKA 3OMD" wikidata:Q15410220 chebi:82913;chebi:133668 inchikey:PFDUUKDQEHURQC-ZETCQYMHSA-N pubchem.compound:9307;pubchem.compound:25273143 chemspider:8948 hmdb:HMDB0060747 3-Methoxytyramine Metabolite chebi:1582 "AKA 3MT" wikidata:Q4634167 chebi:1582 inchikey:DIVQKHQLANKJQO-UHFFFAOYSA-N pubchem.compound:1669 chemspider:1606 hmdb:HMDB0000022 kegg.compound:C05587 L-Dopa Metabolite chebi:57504 "AKA levodopa" wikidata:Q106345614;wikidata:Q300989 chebi:15765;chebi:57504 inchikey:WTDRDQBEARUVNC-LURJTMIESA-N pubchem.compound:6047;pubchem.compound:6971033 chemspider:5824 hmdb:HMDB0000181 kegg.compound:C00355 PLP Metabolite chebi:18405 "AKA Pyridoxal phosphate, cofactor" wikidata:Q418957 chebi:18405 inchikey:NGVDGCNFYWLIFO-UHFFFAOYSA-N pubchem.compound:1051 chemspider:1022 hmdb:HMDB0001491 kegg.compound:C00018 BH4 Metabolite chebi:30436 "AKA tetrahydropterin, cofactor" wikidata:Q74232496 chebi:30436 qBH2 Metabolite chebi:43120 "AKA tetrahydropterin, cofactor" wikidata:Q28529687;wikidata:Q27093537 chebi:43120;chebi:140754;chebi:20680 inchikey:ZHQJVZLJDXWFFX-UHFFFAOYSA-N;inchikey:ZHQJVZLJDXWFFX-RPDRRWSUSA-N pubchem.compound:135398653;pubchem.compound:133246;pubchem.compound:135476784;pubchem.compound:1879 chemspider:4573556;chemspider:21238088;chemspider:117564;chemspider:21238640;chemspider:21233482;chemspider:1808 hmdb:HMDB0002215 kegg.compound:C00268 SLC18A2 GeneProduct ncbigene:6571 "AKA VMAT2" ensembl:ENSG00000165646 ncbigene:6571 hgnc.symbol:SLC18A2 uniprot:Q05940 DBH Protein uniprot:P09172 "AKA Dopamine beta-hydrocylase
Located membrane-bound and intra-vesicular [PMID: 30372766]" ensembl:ENSG00000123454 ncbigene:1621 hgnc.symbol:DBH uniprot:Q5T382;uniprot:P09172 Aldehyde dehydrogenase Protein eccode:1.2.1.3 "" SLC6A3 Protein uniprot:Q01959 "" ensembl:ENSG00000142319 ncbigene:6531 hgnc.symbol:SLC6A3 uniprot:Q01959 PNMT Protein uniprot:P11086 "AKA Phenylethanolamine N-methyltransferase" ensembl:ENSG00000141744 ncbigene:5409 hgnc.symbol:PNMT uniprot:A8MT87;uniprot:J3QRI3;uniprot:P11086 TH Protein uniprot:P07101 "AKA Tyrosine 3-mono oxygenase, TYH" ensembl:ENSG00000180176 ncbigene:7054 hgnc.symbol:TH uniprot:H0Y670;uniprot:F8W8M5;uniprot:H0Y677;uniprot:E7EQI0;uniprot:P07101 MAOA Protein ncbigene:4128 "AKA Monoamine oxidase A" ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 AADC Protein uniprot:P20711 "AKA Aromatic L-amino acid decarboxylase, DCC" ensembl:ENSG00000132437 ncbigene:1644 hgnc.symbol:DDC uniprot:H7BZF7;uniprot:A0A0S2Z3N4;uniprot:C9JMP0;uniprot:P20711;uniprot:F8WER1;uniprot:A0A087WU57;uniprot:A0A087WV24 TPH Protein eccode:1.14.16.4 "AKA Tryptophan hydroxylase" TPH1 Protein uniprot:P17752 "AKA Tryptophan hydroxylase
Expressed in skin, gut and pineal gland (tissues where serotonint is expressed), and also in the CNS." ensembl:ENSG00000129167 ncbigene:7166 hgnc.symbol:TPH1 uniprot:E9PR49;uniprot:E7EMX4;uniprot:P17752 TPH2 Protein uniprot:Q8IWU9 "AKA Tryptophan hydroxylase
Expressed in neuronal cells, and the predominant isoform of the Central Nervous System (CNS)." ensembl:ENSG00000139287 ncbigene:121278 hgnc.symbol:TPH2 uniprot:Q8IWU9 COMT Protein uniprot:P21964 "AKA Catechol-O- metyltransferase" ensembl:ENSG00000093010 ncbigene:1312 hgnc.symbol:COMT uniprot:H7BZ45;uniprot:A0A7I2V3G7;uniprot:E7EMS6;uniprot:P21964;uniprot:A0A7I2V370;uniprot:A0A140VJG8;uniprot:E7EUU8;uniprot:F8WBW9