Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps SAM Metabolite chebi:67040 "" wikidata:Q27135598 chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N pubchem.compound:34755 chemspider:31982 kegg.compound:C00019 serine Metabolite chebi:17115 "" wikidata:Q106345473;wikidata:Q183290 chebi:33384;chebi:17115 inchikey:MTCFGRXMJLQNBG-REOHCLBHSA-N pubchem.compound:5951;pubchem.compound:6857581 chemspider:5736 hmdb:HMDB0000187 kegg.compound:C00065 THF Metabolite chebi:20506 "" wikidata:Q53668656 chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N pubchem.compound:135444742;pubchem.compound:91443 chemspider:82572 hmdb:HMDB0001846;hmdb:HMDB0304496 kegg.compound:C00101 5-Methyl-THF Metabolite chebi:15641 "" wikidata:Q192553;wikidata:Q27290485 chebi:15641 inchikey:ZNOVTXRBGFNYRX-STQMWFEESA-N;inchikey:ZNOVTXRBGFNYRX-ZGTCLIOFSA-N;inchikey:ZNOVTXRBGFNYRX-ABLWVSNPSA-N pubchem.compound:439234;pubchem.compound:135398561;pubchem.compound:9825434;pubchem.compound:135415868 chemspider:388371;chemspider:8001181 hmdb:HMDB0001396 kegg.compound:C00440 NH₄⁺ Metabolite chebi:28938 "" wikidata:Q190901 chebi:28938 inchikey:QGZKDVFQNNGYKY-UHFFFAOYSA-O pubchem.compound:223;pubchem.compound:16741146 chemspider:218 hmdb:HMDB0041827 kegg.compound:C01342 L-glutamic acid Metabolite chebi:16015 "" wikidata:Q26995161 chebi:16015 inchikey:WHUUTDBJXJRKMK-VKHMYHEASA-N pubchem.compound:44272391;pubchem.compound:88747398;pubchem.compound:33032 chemspider:30572 hmdb:HMDB0000148 kegg.compound:C00025 SAH Metabolite chebi:16680 "" wikidata:Q106345616;wikidata:Q307434 chebi:16680;chebi:57856 inchikey:ZJUKTBDSGOFHSH-WFMPWKQPSA-N pubchem.compound:25246222;pubchem.compound:439155 chemspider:388301 hmdb:HMDB0000939 kegg.compound:C00021 CO₂ Metabolite chebi:16526 "" wikidata:Q1997 chebi:16526 inchikey:CURLTUGMZLYLDI-UHFFFAOYSA-N pubchem.compound:280 chemspider:274 hmdb:HMDB0001967 kegg.compound:C00011 glycine Metabolite chebi:15428 "" wikidata:Q106345678;wikidata:Q620730 chebi:15428;chebi:57305 inchikey:DHMQDGOQFOQNFH-UHFFFAOYSA-N pubchem.compound:750;pubchem.compound:5257127 chemspider:730 hmdb:HMDB0000123 kegg.compound:C00037 N-formimidoyl-L-glutamate Metabolite chebi:58928 "Based on Rhea, the side metabolite is not Histidine" wikidata:Q27126350 chebi:58928 inchikey:NRXIKWMTVXPVEF-BYPYZUCNSA-M pubchem.compound:25246274 Homocysteine Metabolite chebi:17230 "" wikidata:Q192466 chebi:58065;chebi:17230 inchikey:FFFHZYDWPBMWHY-UHFFFAOYSA-N pubchem.compound:778;pubchem.compound:49791978 chemspider:757 hmdb:HMDB0000742 kegg.compound:C05330 DHF Metabolite chebi:15633 "AKA 7,8-DHF" wikidata:Q192367 chebi:15633 inchikey:OZRNSSUDZOLUSN-LBPRGKRZSA-N pubchem.compound:98792;pubchem.compound:135398604 chemspider:89228 hmdb:HMDB0001056 kegg.compound:C00415 Methionine Metabolite chebi:16643 "" wikidata:Q106345486;wikidata:Q22124685 chebi:16643;chebi:57844 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N pubchem.compound:6137 chemspider:5907 hmdb:HMDB0000696 kegg.compound:C00073 Folic acid Metabolite chebi:27470 "" wikidata:Q127060 chebi:27470 inchikey:OVBPIULPVIDEAO-LBPRGKRZSA-N pubchem.compound:6037;pubchem.compound:135398658 chemspider:5815 hmdb:HMDB0000121 kegg.compound:C00504 5,10-Methylene-THF Metabolite chebi:1989 "" wikidata:Q26995704 chebi:1989 inchikey:QYNUQALWYRSVHF-OLZOCXBDSA-N pubchem.compound:163026560;pubchem.compound:445117;pubchem.compound:135398645;pubchem.compound:163026559 chemspider:392851 hmdb:HMDB0001533 kegg.compound:C00143 Vitamin B12 Metabolite chebi:30411 "" wikidata:Q3329800 chebi:30411 5-formimino-THF Metabolite chebi:15639 "" wikidata:Q27098161 chebi:15639 inchikey:YCWUVLPMLLBDCU-UHFFFAOYSA-N;inchikey:YCWUVLPMLLBDCU-STQMWFEESA-N pubchem.compound:530;pubchem.compound:5459780;pubchem.compound:135398659 chemspider:11267158;chemspider:20126557 hmdb:HMDB0001534 kegg.compound:C00664 5,10-Methenyl-THF Metabolite chebi:15638 "" wikidata:Q2823228 chebi:15638 inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-N;inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-O pubchem.compound:135450599;pubchem.compound:135405047;pubchem.compound:137250216 chemspider:559356 hmdb:HMDB0001354 kegg.compound:C00445 GAR Metabolite chebi:18349 "" wikidata:Q100600980 chebi:18349 inchikey:OBQMLSFOUZUIOB-SHUUEZRQSA-N;inchikey:OBQMLSFOUZUIOB-HJZCUYRDSA-N pubchem.compound:160913;pubchem.compound:5459918 chemspider:141370 hmdb:HMDB0002022 kegg.compound:C03838 Formyl-GAR Metabolite chebi:18272 "" wikidata:Q3381513 chebi:18272 inchikey:VDXLUNDMVKSKHO-ZRTZXPPTSA-N;inchikey:VDXLUNDMVKSKHO-XVFCMESISA-N pubchem.compound:16048611;pubchem.compound:130805 chemspider:115687 hmdb:HMDB0001308 kegg.compound:C04376 AICAR Metabolite chebi:2030 "" wikidata:Q27067435 chebi:2030 inchikey:DVNYTAVYBRSTGK-UHFFFAOYSA-N pubchem.compound:9679 chemspider:9298 hmdb:HMDB0003192 kegg.compound:C04051 FAICAR Metabolite chebi:18381 "" wikidata:Q2817110 chebi:18381 inchikey:ABCOOORLYAOBOZ-KQYNXXCUSA-N pubchem.compound:166760 chemspider:145893 hmdb:HMDB0001439 kegg.compound:C04734 10-Formyl-THF Metabolite chebi:15637 "" wikidata:Q47459238 chebi:15637 inchikey:AUFGTPPARQZWDO-YUZLPWPTSA-N pubchem.compound:122347;pubchem.compound:135450591 chemspider:109092 hmdb:HMDB0000972 kegg.compound:C00234 5-Formyl-THF Metabolite chebi:15640 "" wikidata:Q45435667 chebi:15640 inchikey:VVIAGPKUTFNRDU-ABLWVSNPSA-N pubchem.compound:135403648 chemspider:5784 kegg.compound:C03479 dTMP Metabolite chebi:17013 "" wikidata:Q90535442;wikidata:Q23905769 chebi:17013 inchikey:QSJFDOVQWZVUQG-KAVNDROISA-N;inchikey:GYOZYWVXFNDGLU-XLPZGREQSA-N pubchem.compound:9700;pubchem.compound:53477735 chemspider:9319 hmdb:HMDB0001227;hmdb:HMDB0001570 kegg.compound:C00364 dUMP Metabolite chebi:17622 "" wikidata:Q2741362 chebi:17622 inchikey:JSRLJPSBLDHEIO-SHYZEUOFSA-N pubchem.compound:65063 chemspider:58574 hmdb:HMDB0001409 kegg.compound:C00365 qDHF Metabolite wikidata:Q117085463 "AKA quinoid DHF; SMILES: Nc1-n=C2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N=c2C(=O)N=1 " wikidata:Q117085463 inchikey:AIZSNLNTIFEHJG-KIYNQFGBSA-N pubchem.compound:135659081 7.8-dihydropterin Metabolite chebi:64277 "Reference [PMID:30587505] does not provide info on stereochemistry" wikidata:Q5276421 chebi:64277 inchikey:FEMXZDUTFRTWPE-UHFFFAOYSA-N pubchem.compound:252;pubchem.compound:135402011 chemspider:247 hmdb:HMDB0247294 kegg.compound:C02953 iminium ion Metabolite chebi:35286 "" wikidata:Q2409792 chebi:35286 formaldehyde Metabolite chebi:1684 "" wikidata:Q27105492 chebi:1684 inchikey:YWTDWORQGPLRLL-RXKIGOLRSA-N pubchem.compound:13847328 chemspider:20015998 hmdb:HMDB0006753 kegg.compound:C05474 lipidmaps:LMST02030275 MTHFD1 Protein uniprot:P11586 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8V8TKR5;uniprot:A0A8V8TL46;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:A0A8V8TL50;uniprot:A0A8V8TKS0;uniprot:A0A8V8TMA9;uniprot:A0A8V8TKT4;uniprot:V9GZ32;uniprot:V9GZ78;uniprot:A0A8V8TMA4;uniprot:A0A8C8UXK2;uniprot:P11586 QDPR Protein uniprot:P09417 "" ensembl:ENSG00000151552 ncbigene:5860 hgnc.symbol:QDPR uniprot:B7Z415;uniprot:A0A140VKA9;uniprot:P09417;uniprot:H0Y8F7;uniprot:D6RGG7;uniprot:D6RHJ7 MTHFD1 Protein uniprot:P11586 "" ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8V8TKR5;uniprot:A0A8V8TL46;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:A0A8V8TL50;uniprot:A0A8V8TKS0;uniprot:A0A8V8TMA9;uniprot:A0A8V8TKT4;uniprot:V9GZ32;uniprot:V9GZ78;uniprot:A0A8V8TMA4;uniprot:A0A8C8UXK2;uniprot:P11586 SHMT1 Protein uniprot:P34896 "" ensembl:ENSG00000176974 ncbigene:6470 hgnc.symbol:SHMT1 uniprot:J3KRZ5;uniprot:J3KRK5;uniprot:P34896 GARTF Protein uniprot:C9JKQ7 "" ensembl:ENSG00000159131 ncbigene:2618 hgnc.symbol:GART uniprot:C9JKQ7;uniprot:C9JTV6;uniprot:F8WD69;uniprot:H7C366;uniprot:C9JBJ1;uniprot:P22102;uniprot:C9JZG2 MTHFS Protein ensembl:ENSG00000136371 "" ensembl:ENSG00000136371 ncbigene:10588 hgnc.symbol:MTHFS uniprot:H3BMB9;uniprot:A0A0U1RQM3;uniprot:H3BN04;uniprot:P49914 MTHFCH Protein eccode:3.5.4.9 "MTHFCH: methenyl-THF cyclohydrolase" SLC46A1 Protein uniprot:Q96NT5 "AKA PCFT" ensembl:ENSG00000076351 ncbigene:113235 hgnc.symbol:SLC46A1 uniprot:A0A024QZ44;uniprot:A0A024QZ15;uniprot:J3QRF7;uniprot:K7EPJ7;uniprot:Q96NT5;uniprot:J3KTE6;uniprot:J3QL21 FOLR1 Protein uniprot:P15328 "AKA Folate receptor alpha" ensembl:ENSG00000110195 ncbigene:2348 hgnc.symbol:FOLR1 uniprot:A0A024R5H1;uniprot:P15328 AICART Protein uniprot:P31939 "AKA ATIC, PURH" ensembl:ENSG00000138363 ncbigene:471 hgnc.symbol:ATIC uniprot:C9JLK0;uniprot:F2Z3E8;uniprot:V9HWH7;uniprot:F8WEF0;uniprot:P31939;uniprot:H7C1S2 TS Protein uniprot:P04818 "AKA TYMS" ensembl:ENSG00000176890 ncbigene:7298 hgnc.symbol:TYMS uniprot:P04818;uniprot:Q53Y97 ALDH1L1 Protein uniprot:O75891 "AKA FTHFD, cytosolic" ensembl:ENSG00000144908 ncbigene:10840 hgnc.symbol:ALDH1L1 uniprot:O75891;uniprot:C9IZ36;uniprot:F2Z324;uniprot:C9JY00;uniprot:D6RFJ7;uniprot:A0A0S2Z586;uniprot:C9JYZ6;uniprot:F8WC34 MS Protein uniprot:Q99707 "" ensembl:ENSG00000116984 ncbigene:4548 hgnc.symbol:MTR uniprot:A0A6Q8PGK3;uniprot:A0A7P0TAV2;uniprot:A0A7P0T9G7;uniprot:Q99707;uniprot:A0A494C1A2;uniprot:A0A7P0T956;uniprot:A0A7P0TA06;uniprot:A0A7P0TAJ0;uniprot:A0A494C064;uniprot:B1ANE3 SHMT Protein uniprot:P34897 "AKA SHMT2; Rhea and UniProt confirm the '2' addition, whereas the Blau book chapter only mentions SHMT." ensembl:ENSG00000182199 ncbigene:6472 hgnc.symbol:SHMT2 uniprot:G3V4X0;uniprot:H0YIZ0;uniprot:G3V2W0;uniprot:G3V2Y4;uniprot:G3V4T0;uniprot:G3V241;uniprot:G3V3Y8;uniprot:G3V4W5;uniprot:A0A024RB99;uniprot:G3V540;uniprot:G3V3C6;uniprot:G3V2Y1;uniprot:V9HW06;uniprot:G3V2D2;uniprot:G3V2E4;uniprot:P34897;uniprot:G3V5L0 FTCD Protein uniprot:O95954 "AKA FITHFCH" ensembl:ENSG00000160282 ncbigene:10841 hgnc.symbol:FTCD uniprot:O95954;uniprot:H7C315;uniprot:B7WPK3;uniprot:A0A804HKA5;uniprot:Q49AR5 DHFR Protein uniprot:B0YJ76 "" ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 MTHFR Protein uniprot:P42898 "" ensembl:ENSG00000177000 ncbigene:4524 hgnc.symbol:MTHFR uniprot:A0A286YF17;uniprot:Q5SNW5;uniprot:P42898;uniprot:Q5SNW7;uniprot:F8W9T8;uniprot:A0A286YFD0;uniprot:A0A286YF47;uniprot:A0A1B0GXD9;uniprot:L7P8G6 SLC19A1 Protein uniprot:P41440 "AKA Folate receptor alpha" ensembl:ENSG00000173638 ncbigene:6573 hgnc.symbol:SLC19A1 uniprot:C9J8K6;uniprot:H3BTQ3;uniprot:C9JKP4;uniprot:P41440;uniprot:H0Y4T2;uniprot:E9PIL5 ALDH1L2 Protein uniprot:Q3SY69 "AKA FTHFD, mitochondrial" ensembl:ENSG00000136010 ncbigene:160428 hgnc.symbol:ALDH1L2 uniprot:Q3SY69;uniprot:H0YHN9;uniprot:A0A494C1M4 MTHFD2 Protein uniprot:P13995 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000065911 ncbigene:10797 hgnc.symbol:MTHFD2 uniprot:F8WF89;uniprot:A0A7I2V2U6;uniprot:P13995;uniprot:B9A062;uniprot:F8WF06;uniprot:B8ZZU9;uniprot:A0A7I2V482;uniprot:A0A7I2V2G4;uniprot:A0A7I2V3T1;uniprot:A0A7I2YQD4 MTHFD2L Protein uniprot:Q9H903 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000163738 ncbigene:441024 hgnc.symbol:MTHFD2L uniprot:Q8IY64;uniprot:F8W7P9;uniprot:Q9H903