Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI SAM Metabolite chebi:67040 "" wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N serine Metabolite chebi:17822 "" wikidata:Q26997410 chebi:17822;chebi:17822 inchikey:MTCFGRXMJLQNBG-UHFFFAOYSA-N THF Metabolite chebi:20506 "" wikidata:Q53668656 chebi:20506;chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N 5-Methyl-THF Metabolite chebi:15641 "" wikidata:Q192553 chebi:15641;chebi:15641 inchikey:ZNOVTXRBGFNYRX-STQMWFEESA-N;inchikey:ZNOVTXRBGFNYRX-ZGTCLIOFSA-N NH4+ Metabolite chebi:28938 "" wikidata:Q190901 chebi:28938;chebi:28938 inchikey:QGZKDVFQNNGYKY-UHFFFAOYSA-O L-glutamic acid Metabolite chebi:16015 "" wikidata:Q26995161 chebi:16015;chebi:16015 inchikey:WHUUTDBJXJRKMK-VKHMYHEASA-N SAH Metabolite chebi:16680 "" wikidata:Q307434 chebi:16680;chebi:16680 inchikey:ZJUKTBDSGOFHSH-WFMPWKQPSA-N CO2 Metabolite chebi:16526 "" wikidata:Q1997 chebi:16526;chebi:16526 inchikey:CURLTUGMZLYLDI-UHFFFAOYSA-N glycine Metabolite chebi:15428 "" wikidata:Q620730 chebi:15428;chebi:15428 inchikey:DHMQDGOQFOQNFH-UHFFFAOYSA-N N-formimidoyl-L-glutamate Metabolite chebi:58928 "Based on Rhea, the side metabolite is not Histidine" wikidata:Q27126350 chebi:58928;chebi:58928 inchikey:NRXIKWMTVXPVEF-BYPYZUCNSA-M Homocysteine Metabolite chebi:17230 "" wikidata:Q192466 chebi:17230;chebi:17230 inchikey:FFFHZYDWPBMWHY-UHFFFAOYSA-N DHF Metabolite chebi:15633 "AKA 7,8-DHF" wikidata:Q192367 chebi:15633;chebi:15633 inchikey:OZRNSSUDZOLUSN-LBPRGKRZSA-N Methionine Metabolite chebi:16643 "" wikidata:Q22124685 chebi:16643;chebi:16643 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N Folic acid Metabolite chebi:27470 "" wikidata:Q127060 chebi:27470;chebi:27470 inchikey:OVBPIULPVIDEAO-LBPRGKRZSA-N 5,10-Methylene-THF Metabolite chebi:1989 "" wikidata:Q26995704 chebi:1989;chebi:1989 inchikey:QYNUQALWYRSVHF-OLZOCXBDSA-N Vitamin B12 Metabolite chebi:30411 "" wikidata:Q3329800 chebi:30411;chebi:30411 5-formimino-THF Metabolite chebi:15639 "" wikidata:Q27098161 chebi:15639;chebi:15639 inchikey:YCWUVLPMLLBDCU-UHFFFAOYSA-N;inchikey:YCWUVLPMLLBDCU-STQMWFEESA-N 5,10-Methenyl-THF Metabolite chebi:15638 "" wikidata:Q2823228 chebi:15638;chebi:15638 inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-N;inchikey:MEANFMOQMXYMCT-OLZOCXBDSA-O GAR Metabolite chebi:18349 "" wikidata:Q100600980 chebi:18349;chebi:18349 inchikey:OBQMLSFOUZUIOB-SHUUEZRQSA-N;inchikey:OBQMLSFOUZUIOB-HJZCUYRDSA-N Formyl-GAR Metabolite chebi:18272 "" wikidata:Q3381513 chebi:18272;chebi:18272 inchikey:VDXLUNDMVKSKHO-ZRTZXPPTSA-N;inchikey:VDXLUNDMVKSKHO-XVFCMESISA-N AICAR Metabolite chebi:2030 "" wikidata:Q27067435 chebi:2030;chebi:2030 inchikey:DVNYTAVYBRSTGK-UHFFFAOYSA-N FAICAR Metabolite chebi:18381 "" wikidata:Q2817110 chebi:18381;chebi:18381 inchikey:ABCOOORLYAOBOZ-KQYNXXCUSA-N 10-Formyl-THF Metabolite chebi:15637 "" wikidata:Q27098160 chebi:15637;chebi:15637 inchikey:AUFGTPPARQZWDO-YUZLPWPTSA-N;inchikey:AUFGTPPARQZWDO-YPMHNXCESA-N 5-Formyl-THF Metabolite chebi:15640 "" wikidata:Q45435667 chebi:15640;chebi:15640 inchikey:VVIAGPKUTFNRDU-ABLWVSNPSA-N dTMP Metabolite chebi:17013 "" wikidata:Q23905769 chebi:17013;chebi:17013 inchikey:QSJFDOVQWZVUQG-KAVNDROISA-N;inchikey:GYOZYWVXFNDGLU-XLPZGREQSA-N dUMP Metabolite chebi:17622 "" wikidata:Q2741362 chebi:17622;chebi:17622 inchikey:JSRLJPSBLDHEIO-SHYZEUOFSA-N Folic acid Metabolite chebi:27470 "" wikidata:Q127060 chebi:27470;chebi:27470 inchikey:OVBPIULPVIDEAO-LBPRGKRZSA-N THF Metabolite chebi:20506 "" wikidata:Q53668656 chebi:20506;chebi:20506 inchikey:MSTNYGQPCMXVAQ-KIYNQFGBSA-N;inchikey:MSTNYGQPCMXVAQ-PXYINDEMSA-N 5-Methyl-THF Metabolite chebi:15641 "" wikidata:Q192553 chebi:15641;chebi:15641 inchikey:ZNOVTXRBGFNYRX-STQMWFEESA-N;inchikey:ZNOVTXRBGFNYRX-ZGTCLIOFSA-N qDHF Metabolite wikidata:Q117085463 "AKA quinoid DHF; SMILES: Nc1-n=C2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N=c2C(=O)N=1 " 7.8-dihydropterin Metabolite chebi:64277 "Reference [PMID:30587505] does not provide info on stereochemistry" wikidata:Q5276421 chebi:64277;chebi:64277 inchikey:FEMXZDUTFRTWPE-UHFFFAOYSA-N iminium ion Metabolite chebi:35286 "" chebi:35286 formaldehyde Metabolite chebi:1684 "" wikidata:Q27105492 chebi:1684;chebi:1684 inchikey:YWTDWORQGPLRLL-RXKIGOLRSA-N MTHFD1 Protein uniprot:P11586 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 QDPR Protein uniprot:P09417 "" ensembl:ENSG00000151552 ncbigene:5860 hgnc.symbol:QDPR uniprot:B7Z415;uniprot:A0A140VKA9;uniprot:P09417;uniprot:H0Y8F7;uniprot:D6RGG7;uniprot:D6RHJ7 MTHFD1 Protein uniprot:P11586 "" ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 SHMT1 Protein uniprot:P34896 "" ensembl:ENSG00000176974 ncbigene:6470 hgnc.symbol:SHMT1 uniprot:J3KRZ5;uniprot:J3KRK5;uniprot:P34896 GARTF Protein uniprot:C9JKQ7 "" ensembl:ENSG00000159131 ncbigene:2618 hgnc.symbol:GART uniprot:C9JKQ7;uniprot:C9JTV6;uniprot:F8WD69;uniprot:H7C366;uniprot:C9JBJ1;uniprot:P22102;uniprot:C9JZG2 MTHFS Protein ensembl:ENSG00000136371 "" ensembl:ENSG00000136371 ncbigene:10588 hgnc.symbol:MTHFS uniprot:H3BMB9;uniprot:A0A0U1RQM3;uniprot:H3BN04;uniprot:P49914 MTHFCH Protein eccode:3.5.4.9 "MTHFCH: methenyl-THF cyclohydrolase" SLC46A1 Protein uniprot:Q96NT5 "AKA PCFT" ensembl:ENSG00000076351 ncbigene:113235 hgnc.symbol:SLC46A1 uniprot:A0A024QZ44;uniprot:A0A024QZ15;uniprot:J3QRF7;uniprot:K7EPJ7;uniprot:Q96NT5;uniprot:J3KTE6;uniprot:J3QL21 FOLR1 Protein uniprot:P15328 "AKA Folate receptor alpha" ensembl:ENSG00000110195 ncbigene:2348 hgnc.symbol:FOLR1 uniprot:A0A024R5H1;uniprot:P15328 AICART Protein uniprot:P31939 "AKA ATIC, PURH" ensembl:ENSG00000138363 ncbigene:471 hgnc.symbol:ATIC uniprot:C9JLK0;uniprot:F2Z3E8;uniprot:V9HWH7;uniprot:F8WEF0;uniprot:P31939;uniprot:H7C1S2 TS Protein uniprot:P04818 "AKA TYMS" ensembl:ENSG00000176890 ncbigene:7298 hgnc.symbol:TYMS uniprot:P04818;uniprot:Q53Y97 ALDH1L1 Protein uniprot:O75891 "AKA FTHFD, cytosolic" ensembl:ENSG00000144908 ncbigene:10840 hgnc.symbol:ALDH1L1 uniprot:O75891;uniprot:C9IZ36;uniprot:F2Z324;uniprot:C9JY00;uniprot:D6RFJ7;uniprot:A0A0S2Z586;uniprot:C9JYZ6;uniprot:F8WC34 MS Protein uniprot:Q99707 "" ensembl:ENSG00000116984 ncbigene:4548 hgnc.symbol:MTR uniprot:A0A6Q8PGK3;uniprot:A0A7P0TAV2;uniprot:A0A7P0T9G7;uniprot:Q99707;uniprot:A0A494C1A2;uniprot:A0A7P0T956;uniprot:A0A7P0TA06;uniprot:A0A7P0TAJ0;uniprot:A0A494C064;uniprot:B1ANE3 SHMT Protein uniprot:P34897 "AKA SHMT2; Rhea and UniProt confirm the '2' addition, whereas the Blau book chapter only mentions SHMT." ensembl:ENSG00000182199 ncbigene:6472 hgnc.symbol:SHMT2 uniprot:G3V4X0;uniprot:H0YIZ0;uniprot:G3V2W0;uniprot:G3V2Y4;uniprot:G3V4T0;uniprot:G3V241;uniprot:G3V3Y8;uniprot:G3V4W5;uniprot:A0A024RB99;uniprot:G3V540;uniprot:G3V3C6;uniprot:G3V2Y1;uniprot:V9HW06;uniprot:G3V2D2;uniprot:G3V2E4;uniprot:P34897;uniprot:G3V5L0 FTCD Protein uniprot:O95954 "AKA FITHFCH" ensembl:ENSG00000160282 ncbigene:10841 hgnc.symbol:FTCD uniprot:O95954;uniprot:H7C315;uniprot:B7WPK3;uniprot:A0A804HKA5;uniprot:Q49AR5 DHFR Protein uniprot:B0YJ76 "" ensembl:ENSG00000228716 ncbigene:1719 hgnc.symbol:DHFR uniprot:B4DM58;uniprot:B0YJ76;uniprot:P00374 MTHFR Protein uniprot:P42898 "" ensembl:ENSG00000177000 ncbigene:4524 hgnc.symbol:MTHFR uniprot:A0A286YF17;uniprot:Q5SNW5;uniprot:P42898;uniprot:Q5SNW7;uniprot:F8W9T8;uniprot:A0A286YFD0;uniprot:A0A286YF47;uniprot:A0A1B0GXD9;uniprot:L7P8G6 MTHFD1 Protein uniprot:P11586 "" ensembl:ENSG00000100714 ncbigene:4522 hgnc.symbol:MTHFD1 uniprot:A0A8C8UXK2;uniprot:P11586;uniprot:A0A494C1T2;uniprot:F5H2F4;uniprot:V9GYY3;uniprot:V9GY75;uniprot:V9GZ32;uniprot:V9GZ78 SHMT1 Protein uniprot:P34896 "" ensembl:ENSG00000176974 ncbigene:6470 hgnc.symbol:SHMT1 uniprot:J3KRZ5;uniprot:J3KRK5;uniprot:P34896 SLC19A1 Protein uniprot:P41440 "AKA Folate receptor alpha" ensembl:ENSG00000173638 ncbigene:6573 hgnc.symbol:SLC19A1 uniprot:C9J8K6;uniprot:H3BTQ3;uniprot:C9JKP4;uniprot:P41440;uniprot:H0Y4T2;uniprot:E9PIL5 ALDH1L2 Protein uniprot:Q3SY69 "AKA FTHFD, mitochondrial" ensembl:ENSG00000136010 ncbigene:160428 hgnc.symbol:ALDH1L2 uniprot:Q3SY69;uniprot:H0YHN9;uniprot:A0A494C1M4 MTHFD2 Protein uniprot:P13995 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000065911 ncbigene:10797 hgnc.symbol:MTHFD2 uniprot:F8WF89;uniprot:A0A7I2V2U6;uniprot:P13995;uniprot:B9A062;uniprot:F8WF06;uniprot:B8ZZU9;uniprot:A0A7I2V482;uniprot:A0A7I2V2G4;uniprot:A0A7I2V3T1;uniprot:A0A7I2YQD4 MTHFD2L Protein uniprot:Q9H903 "Found based on EC code for MTHFCH, information in UniProt describes this reaction." ensembl:ENSG00000163738 ncbigene:441024 hgnc.symbol:MTHFD2L uniprot:Q8IY64;uniprot:F8W7P9;uniprot:Q9H903