Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI Choline Metabolite chebi:15354 "Methionine Hypothesis" wikidata:Q193166 chebi:15354;chebi:15354 inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N SAM Metabolite chebi:67040 "SAMdef Hypothesis" wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N Homocysteine thiolactone Metabolite hmdb:HMDB0002287 "Toxic Hypothesis" inchikey:KIWQWJKWBHZMDT-UHFFFAOYSA-N Phosphatidylcholine Metabolite chebi:49183 "Methionine Hypothesis" wikidata:Q75026757 chebi:49183;chebi:49183 [Myelin basic protein]-N-methylarginine Metabolite chebi:10167 "SAMdef Hypothesis" chebi:10167 Dimethylglycine Metabolite chebi:17724 "" wikidata:Q4369 chebi:17724;chebi:17724 inchikey:FFDGPVCHZBVARC-UHFFFAOYSA-N Homocysteine Metabolite chebi:58199 "" wikidata:Q106345493 chebi:58199;chebi:58199 inchikey:FFFHZYDWPBMWHY-VKHMYHEASA-N [Myelin basic protein]-arginine Metabolite chebi:10166 "SAMdef Hypothesis" chebi:10166 Phosphocholine Metabolite chebi:295975 "Methionine Hypothesis" wikidata:Q27225724 chebi:295975;chebi:295975 inchikey:YHHSONZFOIEMCP-UHFFFAOYSA-M Ca2+ Metabolite chebi:29108 "Toxic Hypothesis" wikidata:Q23905776 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N Ceramide Metabolite chebi:17761 "Methionine Hypothesis" wikidata:Q424213 chebi:17761;chebi:17761 Methionine Metabolite chebi:57844 "" wikidata:Q106345486 chebi:57844;chebi:57844 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N CDP-choline Metabolite chebi:58779 "Methionine Hypothesis" wikidata:Q27126045 chebi:58779;chebi:58779 inchikey:RZZPDXZPRHQOCG-OJAKKHQRSA-M Betaine aldehyde Metabolite chebi:15710 "Methionine Hypothesis" wikidata:Q10859645 chebi:15710;chebi:15710 inchikey:SXKNCCSPZDCRFD-UHFFFAOYSA-N betaine Metabolite chebi:17750 "" wikidata:Q10860583 chebi:17750;chebi:17750 inchikey:KWIUHFFTVRNATP-UHFFFAOYSA-N 5,10-Methylene-THF Metabolite chebi:1989 "" wikidata:Q26995704 chebi:1989;chebi:1989 inchikey:QYNUQALWYRSVHF-OLZOCXBDSA-N DAG Metabolite chebi:18035 "Methionine Hypothesis" wikidata:Q161466 chebi:18035;chebi:18035 Sphingomyelin Metabolite chebi:64583 "Methionine Hypothesis" wikidata:Q423143 chebi:64583;chebi:64583 5-Methyl-THF Metabolite chebi:15641 "" wikidata:Q192553 chebi:15641;chebi:15641 inchikey:ZNOVTXRBGFNYRX-STQMWFEESA-N;inchikey:ZNOVTXRBGFNYRX-ZGTCLIOFSA-N SAH Metabolite chebi:16680 "SAMdef Hypothesis" wikidata:Q307434 chebi:16680;chebi:16680 inchikey:ZJUKTBDSGOFHSH-WFMPWKQPSA-N Phosphatidylethanolamine Metabolite chebi:16038 "Methionine Hypothesis" wikidata:Q426095 chebi:16038;chebi:16038 Reactive oxygen species Metabolite wikidata:Q424361 "Toxic Hypothesis" wikidata:Q424361 chebi:26523;chebi:26523 Betaine Metabolite chebi:17750 "Methionine Hypothesis" wikidata:Q10860583 chebi:17750;chebi:17750 inchikey:KWIUHFFTVRNATP-UHFFFAOYSA-N Choline Metabolite chebi:15354 "Methionine Hypothesis" wikidata:Q193166 chebi:15354;chebi:15354 inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N SAM Metabolite chebi:67040 "Methionine Hypothesis" wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N SAM Metabolite chebi:67040 "Methionine Hypothesis" wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N SAM Metabolite chebi:67040 "Methionine Hypothesis" wikidata:Q27135598 chebi:67040;chebi:67040 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-N Homocysteine Metabolite chebi:17230 "Toxic Hypothesis" wikidata:Q192466 chebi:17230;chebi:17230 inchikey:FFFHZYDWPBMWHY-UHFFFAOYSA-N Homocysteine Metabolite chebi:17230 "Toxic Hypothesis" wikidata:Q192466 chebi:17230;chebi:17230 inchikey:FFFHZYDWPBMWHY-UHFFFAOYSA-N Ca2+ Metabolite chebi:29108 "Toxic Hypothesis" wikidata:Q23905776 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N Homocysteine Metabolite chebi:17230 "Toxic Hypothesis" wikidata:Q192466 chebi:17230;chebi:17230 inchikey:FFFHZYDWPBMWHY-UHFFFAOYSA-N Ca2+ Metabolite chebi:29108 "Toxic Hypothesis" wikidata:Q23905776 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N EHMT1 GeneProduct ensembl:ENSG00000181090 "SAMdef Hypothesis" ensembl:ENSG00000181090 ncbigene:79813 hgnc.symbol:EHMT1 uniprot:A0A0D9SEP2;uniprot:A0A0D9SFS4;uniprot:A0A1B0GU48;uniprot:A0A1B0GW79;uniprot:A0A0D9SEQ1;uniprot:A0A1B0GTP4;uniprot:A0A1B0GW12;uniprot:A0A0D9SER3;uniprot:A0A1B0GV89;uniprot:A0A1W2PPZ7;uniprot:A0A1B0GVZ8;uniprot:A0A0C4DGF8;uniprot:A0A0D9SFX4;uniprot:Q9H9B1;uniprot:A0A1B0GUD1;uniprot:A0A0D9SEY2;uniprot:A0A1B0GV09;uniprot:A0A0D9SFD7;uniprot:A0A0D9SFG7;uniprot:A0A1B0GWF6;uniprot:A0A0D9SFM6;uniprot:A0A0D9SF38;uniprot:A0A0D9SER9 MTHFR GeneProduct ensembl:ENSG00000177000 "" ensembl:ENSG00000177000 ncbigene:4524 hgnc.symbol:MTHFR uniprot:A0A286YF17;uniprot:Q5SNW5;uniprot:P42898;uniprot:Q5SNW7;uniprot:F8W9T8;uniprot:A0A286YFD0;uniprot:A0A286YF47;uniprot:A0A1B0GXD9;uniprot:L7P8G6 CASP3 GeneProduct ensembl:ENSG00000164305 "Toxic Hypothesis" ensembl:ENSG00000164305 ncbigene:836 hgnc.symbol:CASP3 uniprot:A8MVM1;uniprot:C9JXR7;uniprot:P42574 DNMT3A GeneProduct ensembl:ENSG00000119772 "SAMdef Hypothesis" ensembl:ENSG00000119772 ncbigene:1788 hgnc.symbol:DNMT3A uniprot:Q9Y6K1;uniprot:F8WE91;uniprot:A0A0C4DG02 DNMT3B GeneProduct ensembl:ENSG00000088305 "SAMdef Hypothesis" ensembl:ENSG00000088305 ncbigene:1789 hgnc.symbol:DNMT3B uniprot:B4DSJ7;uniprot:Q9UBC3;uniprot:A0A2Z2CIT2;uniprot:Q2PJS8 CASP9 GeneProduct ensembl:ENSG00000132906 "Toxic Hypothesis" ensembl:ENSG00000132906 ncbigene:842 hgnc.symbol:CASP9 uniprot:H0Y6Y2;uniprot:Q5JRU2;uniprot:F8VWA5;uniprot:F8VVS7;uniprot:Q5JRU8;uniprot:A0A087WX72;uniprot:H0Y3S8;uniprot:P55211 ASMT GeneProduct ensembl:ENSG00000196433 "SAMdef Hypothesis" ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 EHMT2 GeneProduct ensembl:ENSG00000204371 "" ensembl:ENSG00000204371 ncbigene:10919 hgnc.symbol:EHMT2 uniprot:H0Y4K5;uniprot:A0A024RCN9;uniprot:A2ABF9;uniprot:Q96KQ7;uniprot:A2ABF8 COMT GeneProduct ensembl:ENSG00000093010 "SAMdef Hypothesis" ensembl:ENSG00000093010 ncbigene:1312 hgnc.symbol:COMT uniprot:H7BZ45;uniprot:A0A7I2V3G7;uniprot:E7EMS6;uniprot:P21964;uniprot:A0A7I2V370;uniprot:A0A140VJG8;uniprot:E7EUU8;uniprot:F8WBW9 DNMT1 GeneProduct ensembl:ENSG00000130816 "SAMdef Hypothesis" ensembl:ENSG00000130816 ncbigene:1786 hgnc.symbol:DNMT1 uniprot:A0A7I2V5D0;uniprot:P26358;uniprot:K7EKC3;uniprot:K7ELB1;uniprot:A0A7I2V3F8;uniprot:A0A7I2V5F6;uniprot:A0A7I2YQA8;uniprot:A0A7I2V490;uniprot:A0A7I2YQQ0;uniprot:K7ERQ1;uniprot:K7ENQ6;uniprot:K7EMU8;uniprot:K7EP77;uniprot:K7EJL0;uniprot:K7ER10;uniprot:K7ENW7;uniprot:A0A7I2V311;uniprot:A0A7I2V5F1;uniprot:K7EIZ6;uniprot:A0A7I2V2G5 Cytochrome c Protein uniprot:G4XXL9 "Toxic Hypothesis" ensembl:ENSG00000172115 ncbigene:54205 hgnc.symbol:CYCS uniprot:G4XXL9;uniprot:C9JFR7;uniprot:P99999 NMDA 2D Protein uniprot:O15399 "Toxic Hypothesis" ensembl:ENSG00000105464 ncbigene:2906 hgnc.symbol:GRIN2D uniprot:O15399 HNMT Protein uniprot:P50135 "" ensembl:ENSG00000150540 ncbigene:3176 hgnc.symbol:HNMT uniprot:P50135 NMDA 1 Protein uniprot:Q05586 "Toxic Hypothesis" ensembl:ENSG00000176884 ncbigene:2902 hgnc.symbol:GRIN1 uniprot:A2AVK2;uniprot:Q05586;uniprot:Q5VSF9 NMDA 2A Protein uniprot:F5GZ52 "Toxic Hypothesis" ensembl:ENSG00000183454 ncbigene:2903 hgnc.symbol:GRIN2A uniprot:Q12879;uniprot:A0A1B0GU35;uniprot:A0A6Q8PGD2;uniprot:Q547U9;uniprot:A0A6Q8PHM7;uniprot:A0A1B0GUT1;uniprot:A0A890YTL4;uniprot:A0A1B0GVW1;uniprot:F5GZ52 BHMT Protein uniprot:Q93088 "" ensembl:ENSG00000145692 ncbigene:635 hgnc.symbol:BHMT uniprot:Q93088;uniprot:E5RJH0;uniprot:V9HWA4 Choline kinase alpha Protein uniprot:P35790 "Methionine Hypothesis" ensembl:ENSG00000110721 ncbigene:1119 hgnc.symbol:CHKA uniprot:P35790;uniprot:H0YD02;uniprot:E9PM06 CHDH Protein uniprot:Q8NE62 "Methionine Hypothesis" ensembl:ENSG00000016391 ncbigene:55349 hgnc.symbol:CHDH uniprot:C9J7D8;uniprot:C9JYW4;uniprot:Q8NE62 PEMT Protein uniprot:Q9UBM1 "Methionine Hypothesis" ensembl:ENSG00000133027 ncbigene:10400 hgnc.symbol:PEMT uniprot:J3QLU8;uniprot:D3YTC7;uniprot:J3KTR2;uniprot:Q9UBM1 PRMT Protein uniprot:B4E0W7 "SAMdef Hypothesis" ensembl:ENSG00000003509 ncbigene:55471 hgnc.symbol:NDUFAF7 uniprot:Q7L592;uniprot:B4E0W7;uniprot:C9JP36;uniprot:H7C3N5;uniprot:C9JEL7;uniprot:C9J236;uniprot:C9JS27 SGMS 1 Protein uniprot:D3DWC4 "Methionine Hypothesis" MetRS Protein uniprot:P56192 "Needs annotation
Toxic Hypothesis" ensembl:ENSG00000166986 ncbigene:4141 hgnc.symbol:MARS1 uniprot:F8VS26;uniprot:F8VPL7;uniprot:F8VZZ9;uniprot:F8W0M7;uniprot:F8W0S4;uniprot:H0YHV5;uniprot:F5H2V6;uniprot:H0YIP0;uniprot:H0YI94;uniprot:H0YI27;uniprot:P56192;uniprot:H0YIC2;uniprot:H0YHL6 BADH Protein uniprot:P49419 "Methionine Hypothesis" ensembl:ENSG00000164904 ncbigene:501 hgnc.symbol:ALDH7A1 uniprot:A0A1B0GW77;uniprot:A0A1B0GW65;uniprot:A0A1B0GTY9;uniprot:P49419;uniprot:A0A1B0GTG2;uniprot:A0A1B0GTJ4;uniprot:A0A0J9YWF7;uniprot:A0A1B0GV49;uniprot:H0YHM6;uniprot:A0A0J9YWM6;uniprot:A0A1B0GUA1;uniprot:A0A0J9YWK1;uniprot:F8WDY6;uniprot:A0A1B0GVU0;uniprot:A0A1B0GW82;uniprot:F8WD33;uniprot:A0A1B0GUY0;uniprot:F8VVF2 CHPT-1 Protein uniprot:Q8WUD6 "Methionine Hypothesis" ensembl:ENSG00000111666 ncbigene:56994 hgnc.symbol:CHPT1 uniprot:H0YI24;uniprot:H0YHV7;uniprot:H0YI84;uniprot:F8W1B3;uniprot:Q8WUD6 CCT-alpha Protein uniprot:P49585 "Methionine Hypothesis" ensembl:ENSG00000161217 ncbigene:5130 hgnc.symbol:PCYT1A uniprot:P49585;uniprot:C9JVS0;uniprot:C9J2E1;uniprot:C9JEJ2;uniprot:F8WAZ5;uniprot:F8WBU2;uniprot:C9J050;uniprot:H7C1T3;uniprot:C9JPY0;uniprot:H7BZN1 Cytochrome c Protein uniprot:G4XXL9 "Toxic Hypothesis" ensembl:ENSG00000172115 ncbigene:54205 hgnc.symbol:CYCS uniprot:G4XXL9;uniprot:C9JFR7;uniprot:P99999 EC 2.1.1.79 Protein eccode:2.1.1.79 "" EC 2.1.1.72 Protein eccode:2.1.1.72 ""