Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI Cholesterol Metabolite chebi:16113 "" wikidata:Q43656 chebi:16113;chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N Cyclic fatty acids Metabolite chebi:59238 "" chebi:59238 Cholesterol Metabolite chebi:16113 "" wikidata:Q43656 chebi:16113;chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N Cholesterol Metabolite chebi:16113 "" wikidata:Q43656 chebi:16113;chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N Cholesterol Metabolite chebi:16113 "" wikidata:Q43656 chebi:16113;chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N VLDL Metabolite chebi:39027 "Very low-density lipoprotein (VLDL) is one of the two main TG (triglyceride or triacylglycerol) carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma." wikidata:Q419074 chebi:39027;chebi:39027 IDL Metabolite chebi:132933 "Itermediate-density lipoprotein (IDL), physiologically a short lived species, containd around equimolar amounts of cholesterol and Triglycerides (TG)." wikidata:Q2619230 chebi:132933;chebi:132933 LDL Metabolite chebi:39026 "Low-density lipoprotein (LDL) is one of the two main cholesterol carrying lipoproteins, which are spheroidal macromolecular complexes responsible for transporting lipids through plasma." wikidata:Q28749 chebi:39026;chebi:39026 LPL GeneProduct ensembl:ENSG00000175445 "" ensembl:ENSG00000175445 ncbigene:4023 hgnc.symbol:LPL uniprot:A0A3B3IT60;uniprot:P06858;uniprot:E5RJZ4;uniprot:A0A1B1RVA9;uniprot:E5RHN7;uniprot:E5RJI0;uniprot:E7EW14 LCAT GeneProduct ensembl:ENSG00000213398 "AKA Lecithin-cholesterol acyl transferase" ensembl:ENSG00000213398 ncbigene:3931 hgnc.symbol:LCAT uniprot:J3QKT0;uniprot:A0A140VK24;uniprot:J3QSE5;uniprot:I3L1Q6;uniprot:I3L215;uniprot:P04180;uniprot:I3L3R0;uniprot:I3L0J6 HL GeneProduct uniprot:P11150 "EC 3.1.1.3" ensembl:ENSG00000166035 ncbigene:3990 hgnc.symbol:LIPC uniprot:E7EUJ1;uniprot:E7EUK6;uniprot:P11150 HL GeneProduct uniprot:Q9Y5X9 "EC 3.1.1.3 aka LIPC" ensembl:ENSG00000101670 ncbigene:9388 hgnc.symbol:LIPG uniprot:J3KTN7;uniprot:B4DTR8;uniprot:J3QQQ0;uniprot:A0A024R2B5;uniprot:A0A075B751;uniprot:Q9Y5X9 CETP GeneProduct ensembl:ENSG00000087237 "" ensembl:ENSG00000087237 ncbigene:1071 hgnc.symbol:CETP uniprot:P11597;uniprot:H3BRJ9;uniprot:A0A0S2Z3F6;uniprot:A0A0S2Z3I8 MTP GeneProduct uniprot:P55157 "'Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.' [https://www.uniprot.org/uniprot/P55157]" ensembl:ENSG00000138823 ncbigene:4547 hgnc.symbol:MTTP uniprot:E9PBP6;uniprot:D6R915;uniprot:P55157;uniprot:D6RAB8 PCSK9 GeneProduct ensembl:ENSG00000169174 "" ensembl:ENSG00000169174 ncbigene:255738 hgnc.symbol:PCSK9 uniprot:A0A669KB81;uniprot:A0A669KBG0;uniprot:A0A669KAY4;uniprot:Q8NBP7 ABCA1 GeneProduct ensembl:ENSG00000165029 "" ensembl:ENSG00000165029 ncbigene:19 hgnc.symbol:ABCA1 uniprot:O95477;uniprot:B1AMI1;uniprot:B1AMI2;uniprot:A0A7I2V5U0 LPL GeneProduct ensembl:ENSG00000175445 "" ensembl:ENSG00000175445 ncbigene:4023 hgnc.symbol:LPL uniprot:A0A3B3IT60;uniprot:P06858;uniprot:E5RJZ4;uniprot:A0A1B1RVA9;uniprot:E5RHN7;uniprot:E5RJI0;uniprot:E7EW14 MTP GeneProduct uniprot:P55157 "'Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.' [https://www.uniprot.org/uniprot/P55157]" ensembl:ENSG00000138823 ncbigene:4547 hgnc.symbol:MTTP uniprot:E9PBP6;uniprot:D6R915;uniprot:P55157;uniprot:D6RAB8 LDLR Protein ensembl:ENSG00000130164 "" ensembl:ENSG00000130164 ncbigene:3949 hgnc.symbol:LDLR uniprot:H0YMQ3;uniprot:J3KMZ9;uniprot:H0YMD1;uniprot:H0YM92;uniprot:A0A024R7D5;uniprot:P01130 SR-B1 Protein uniprot:Q8WTV0 "AKA SCARB1; Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux." ensembl:ENSG00000073060 ncbigene:949 hgnc.symbol:SCARB1 uniprot:F5H4X0;uniprot:A0A0S2Z3I2;uniprot:Q8WTV0;uniprot:A0A7P0T913;uniprot:A0A7P0T9B3;uniprot:A0A024RBS4;uniprot:A0A7P0Z4E3;uniprot:A0A7P0Z4J8;uniprot:F5H5E8;uniprot:B7ZKQ9;uniprot:A0A7P0T9I2 LDLRAP1 Protein uniprot:Q5SW96 "AKA Low density lipoprotein receptor adapter protein 1; ARH1
'Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members.' [https://www.uniprot.org/uniprot/Q5SW96]" ensembl:ENSG00000157978 ncbigene:26119 hgnc.symbol:LDLRAP1 uniprot:Q5SW96 Annexin A2 Protein uniprot:P07355 "" ensembl:ENSG00000182718 ncbigene:302 hgnc.symbol:ANXA2 uniprot:H0YNA0;uniprot:H0YKZ7;uniprot:H0YM50;uniprot:H0YMD9;uniprot:H0YNB8;uniprot:P07355;uniprot:H0YKN4;uniprot:H0YMM1;uniprot:H0YMU9;uniprot:H0YMW4;uniprot:A0A7I2V4P4;uniprot:H0YKV8;uniprot:A0A024R5Z7;uniprot:H0YKS4;uniprot:H0YKX9;uniprot:H0YL33;uniprot:H0YLV6;uniprot:H0YN42;uniprot:H0YLE2;uniprot:H0YMD0;uniprot:H0YKL9;uniprot:H0YNP5;uniprot:H0YMT9;uniprot:H0YN28 LDL-receptor Protein uniprot:P01130 "" ensembl:ENSG00000130164 ncbigene:3949 hgnc.symbol:LDLR uniprot:H0YMQ3;uniprot:J3KMZ9;uniprot:H0YMD1;uniprot:H0YM92;uniprot:A0A024R7D5;uniprot:P01130 C-II Protein uniprot:P02655 "AKA Apolipoprotein C2; cofactor for lipoprotein lipase (LPL) enzyme." ensembl:ENSG00000234906 ncbigene:344 hgnc.symbol:APOC2 uniprot:P02655;uniprot:A0A024R0T9;uniprot:V9GYJ8;uniprot:Q6P163;uniprot:V9GZ01 Remnant receptor Protein interpro:IPR038003 "'The chylomicron remnant receptor accepts apoE as a ligand. Chylomicron remnants are removed from the circulation exclusively by the liver, probably because these large complexes can penetrate the unique sinusoidal vascular space. The multifunctional, α2-macroglobulin/LDL receptor-related protein (LRP) is the chylomicron remnant receptor' [https://doi.org/10.1016/B978-1-4160-6189-2.00072-X]" apo B-48 Protein uniprot:P04114 "'Apolipoprotein B(apo B) occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100. ApoB48 is generated when a stop codon (UAA) is created by RNA editing. As a result of the RNA editing, ApoB48 and ApoB100 share a common N-terminal sequence, but ApoB48 lacks ApoB100's C-terminal LDL receptor binding region. In fact, ApoB48 is so called because it constitutes 48% of the sequence for ApoB100. ApoB 48 is a unique protein to chylomicrons from the small intestine. After most of the lipids in the chylomicron have been absorbed, ApoB48 returns to the liver as part of the chylomicron remnant, where it is endocytosed and degraded.' [https://en.wikipedia.org/wiki/Apolipoprotein_B]
Synthesized in small intestine.
Transcript ID: ENST00000233242.4" ensembl:ENSG00000084674 ncbigene:338 hgnc.symbol:APOB uniprot:A0A669KB70;uniprot:A8MUN2;uniprot:P04114 E Protein uniprot:P02649 "AKA APo E, a ligand for receptor mediated endocytosis." ensembl:ENSG00000130203 ncbigene:348 hgnc.symbol:APOE uniprot:H0Y7L5;uniprot:A0A0S2Z3D5;uniprot:P02649;uniprot:E7ERP7;uniprot:E9PEV4 B100 Protein uniprot:P04114 "'Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles.' [https://en.wikipedia.org/wiki/LDL_receptor]
Synthesized in liver." ensembl:ENSG00000084674 ncbigene:338 hgnc.symbol:APOB uniprot:A0A669KB70;uniprot:A8MUN2;uniprot:P04114 apo B-48 Protein uniprot:P04114 "'Apolipoprotein B(apo B) occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100. ApoB48 is generated when a stop codon (UAA) is created by RNA editing. As a result of the RNA editing, ApoB48 and ApoB100 share a common N-terminal sequence, but ApoB48 lacks ApoB100's C-terminal LDL receptor binding region. In fact, ApoB48 is so called because it constitutes 48% of the sequence for ApoB100. ApoB 48 is a unique protein to chylomicrons from the small intestine. After most of the lipids in the chylomicron have been absorbed, ApoB48 returns to the liver as part of the chylomicron remnant, where it is endocytosed and degraded.' [https://en.wikipedia.org/wiki/Apolipoprotein_B]
Synthesized in small intestine." ensembl:ENSG00000084674 ncbigene:338 hgnc.symbol:APOB uniprot:A0A669KB70;uniprot:A8MUN2;uniprot:P04114 E Protein uniprot:P02649 "AKA APo E, a ligand for receptor mediated endocytosis." ensembl:ENSG00000130203 ncbigene:348 hgnc.symbol:APOE uniprot:H0Y7L5;uniprot:A0A0S2Z3D5;uniprot:P02649;uniprot:E7ERP7;uniprot:E9PEV4 A-I Protein uniprot:P02647 "AKA Apo A-I; activator of lecithin-cholesterol acyl transferase (LCAT)." ensembl:ENSG00000118137 ncbigene:335 hgnc.symbol:APOA1 uniprot:P02647;uniprot:A0A024R3E3;uniprot:F8W696 A-II Protein uniprot:P02652 "AKA Apolipoprotein A-II" ensembl:ENSG00000158874 ncbigene:336 hgnc.symbol:APOA2 uniprot:P02652;uniprot:V9GYM3;uniprot:V9GYT0;uniprot:V9GYC1;uniprot:V9GYE3;uniprot:V9GYS1;uniprot:Q76EI7;uniprot:V9GYG9 A-I Protein uniprot:P02647 "AKA Apo A-I; activator of lecithin-cholesterol acyl transferase (LCAT)." ensembl:ENSG00000118137 ncbigene:335 hgnc.symbol:APOA1 uniprot:P02647;uniprot:A0A024R3E3;uniprot:F8W696 B100 Protein uniprot:P04114 "'Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles.' [https://en.wikipedia.org/wiki/LDL_receptor]
Synthesized in liver." ensembl:ENSG00000084674 ncbigene:338 hgnc.symbol:APOB uniprot:A0A669KB70;uniprot:A8MUN2;uniprot:P04114 B100 Protein uniprot:P04114 "'Apoprotein B100 (ApoB-100) is embedded in the outer phospholipid layer of LDL particles.' [https://en.wikipedia.org/wiki/LDL_receptor]
Synthesized in liver." ensembl:ENSG00000084674 ncbigene:338 hgnc.symbol:APOB uniprot:A0A669KB70;uniprot:A8MUN2;uniprot:P04114 C-II Protein uniprot:P02655 "AKA Apolipoprotein C2; cofactor for lipoprotein lipase (LPL) enzyme." ensembl:ENSG00000234906 ncbigene:344 hgnc.symbol:APOC2 uniprot:P02655;uniprot:A0A024R0T9;uniprot:V9GYJ8;uniprot:Q6P163;uniprot:V9GZ01 E Protein uniprot:P02649 "AKA APo E, a ligand for receptor mediated endocytosis." ensembl:ENSG00000130203 ncbigene:348 hgnc.symbol:APOE uniprot:H0Y7L5;uniprot:A0A0S2Z3D5;uniprot:P02649;uniprot:E7ERP7;uniprot:E9PEV4 E Protein uniprot:P02649 "AKA APo E, a ligand for receptor mediated endocytosis." ensembl:ENSG00000130203 ncbigene:348 hgnc.symbol:APOE uniprot:H0Y7L5;uniprot:A0A0S2Z3D5;uniprot:P02649;uniprot:E7ERP7;uniprot:E9PEV4