Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI 2-Oxoadipate Metabolite chemspider:19951093 2-Oxoadipate wikidata:Q27124738 chebi:57499;chebi:57499 inchikey:FGSBNBBHOZHUBO-UHFFFAOYSA-L Anthranilate Metabolite chemspider:4573598 Anthranilate wikidata:Q27101976 chebi:16567;chebi:16567 inchikey:RWZYAGGXGHYGMB-UHFFFAOYSA-M Indole-3-acetate Metabolite chemspider:779 AKA IAA, Indole Acetic Acid; Indole acetic acid is converted to skatole by Lactobacillus, Clostridium, Bacteroides, and others. wikidata:Q27104160 chebi:30854;chebi:30854 inchikey:SEOVTRFCIGRIMH-UHFFFAOYSA-M 5-hydroxykynurenamine Metabolite chebi:62214 5-Hydroxykynurenamine wikidata:Q27131688 chebi:62214;chebi:62214 inchikey:JANBBPTXDKFOQR-UHFFFAOYSA-O (S)-3-Hydroxybutyryl-CoA Metabolite kegg.compound:C01144 (S)-3-Hydroxybutanoyl-CoA wikidata:Q27089442 chebi:15453;chebi:15453 inchikey:QHHKKMYHDBRONY-BEVJUKKNSA-N;inchikey:QHHKKMYHDBRONY-VKBDFPRVSA-N 5-Methoxyindoleacetate Metabolite chemspider:14533147 5-Methoxyindoleacetate wikidata:Q42412390 inchikey:ITSUZTOXIGCANA-UHFFFAOYSA-N 2-Aminomuconate Metabolite kegg.compound:C03824 2-Aminomuconate wikidata:Q2823203 chebi:15745;chebi:15745 inchikey:QCGTZPZKJPTAEP-REDYYMJGSA-N 3-Hydroxy-L-kynurenine Metabolite kegg.compound:C03227 AKA 3-Hydroxy-L-kynurenine, 3H-KYN chebi:17380;chebi:17380 inchikey:VCKPUUFAIGNJHC-LURJTMIESA-N N-formylanthranilate Metabolite wikidata:Q27103061 Formylanthranilate wikidata:Q27103061 chebi:18410;chebi:18410 inchikey:LLLPDUXGHXIXIW-UHFFFAOYSA-M 2-Aminomuconate Metabolite kegg.compound:C02220 2-Aminomuconate chebi:15745;chebi:15745;chebi:16886 inchikey:ZRHONLCTYUYMIQ-HSFFGMMNSA-N 4,8-Dihydroxyquinoline Metabolite chebi:28883 4,8-Dihydroxyquinoline wikidata:Q27103942 chebi:28883;chebi:28883 inchikey:PYELIMVFIITPER-UHFFFAOYSA-N Cinnavalininate Metabolite kegg.compound:C05640 Cinnavalininate wikidata:Q27106176 chebi:3715;chebi:3715 inchikey:FSBKJYLVDRVPTK-UHFFFAOYSA-N 3-Hydroxykynurenamine Metabolite hmdb:HMDB0060281 3-Hydroxykynurenamine inchikey:ODOPEICAGBYCFH-UHFFFAOYSA-N Indole-3-acetaldehyde Metabolite chemspider:778 AKA IAAId wikidata:Q27102813 chebi:18086;chebi:18086 inchikey:WHOOUMGHGSPMGR-UHFFFAOYSA-N Formyl-5-hydroxykynurenamine Metabolite hmdb:HMDB0012948 chebi:28736;chebi:28736 inchikey:CKAXPTWYSHDIBN-UHFFFAOYSA-N 2-Amino-3-carboxymuconate Metabolite kegg.compound:C04409 2-Amino-3-carboxymuconate wikidata:Q2823201 chebi:995;chebi:995 inchikey:KACPVQQHDVBVFC-OIFXTYEKSA-N Serotonin Metabolite chemspider:5013 AKA 3-(2-Aminoethyl)-1H-indol-5-ol wikidata:Q167934 chebi:28790;chebi:28790 inchikey:QZAYGJVTTNCVMB-UHFFFAOYSA-N 3-Hydroxyanthranilate Metabolite chemspider:7822291 AKA 3-Hydroxyanthranilate, 3-HAA wikidata:Q27104371 chebi:36559;chebi:36559 inchikey:WJXSWCUQABXPFS-UHFFFAOYSA-M Formyl-N-acetyl-5-methoxykynurenamine Metabolite kegg.compound:C05642 Formyl-N-acetyl-5-methoxykynurenamine inchikey:JYWNYMJKURVPFH-UHFFFAOYSA-N 5-Hydroxyindoleacetate Metabolite chemspider:10637170 5-Hydroxyindoleacetate wikidata:Q28000005 inchikey:KCWQSNFJXVMEQC-UHFFFAOYSA-N Quinolinate Metabolite chemspider:2777129 wikidata:Q27103076 chebi:19775;chebi:19775 inchikey:LOAUVZALPPNFOQ-UHFFFAOYSA-M Formylkynurenine Metabolite cas:1022-31-7 Formylkynurenine wikidata:Q71982 chebi:18377;chebi:18377 inchikey:BYHJHXPTQMMKCA-UHFFFAOYSA-N 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate Metabolite hmdb:HMDB0004083 chebi:27593;chebi:27593 inchikey:YCJNYHCCOXVYAF-UHFFFAOYSA-N ILA Metabolite chebi:55528 AKA Indole-3-lactic acid wikidata:Q27124345 chebi:55528;chebi:55528 inchikey:XGILAAMKEQUXLS-SNVBAGLBSA-N skatole Metabolite chebi:9171 Indole acetic acid is converted to skatole by Lactobacillus, Clostridium, Bacteroides, and others. wikidata:Q412281 chebi:9171;chebi:9171 inchikey:ZFRKQXVRDFCRJG-UHFFFAOYSA-N Indolepyruvate Metabolite kegg.compound:C00331 AKA IPYA, IP wikidata:Q23905803 chebi:29750;chebi:29750 inchikey:RSTKLPZEZYGQPY-UHFFFAOYSA-N Acetyl-CoA Metabolite cas:72-89-9 Acetyl-CoA wikidata:Q715317 chebi:15351;chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N alpha-tocopherol Metabolite chebi:22470 chebi:22470 Indole Metabolite chebi:35581 wikidata:Q77894008 chebi:35581;chebi:35581 5-Hydroxy-L-tryptophan Metabolite hmdb:HMDB0000472 'The neurotransmitter 5-HT is produced in the brain through the Trp hydroxylase 2 enzyme (TpH2), [...], more than 90% of the body's 5-HT is produced in the gut and particularly in enterochromaffin cells (ECs), a specialized subtype of intestinal epithelial cell.' chebi:17780;chebi:17780 inchikey:LDCYZAJDBXYCGN-VIFPVBQESA-N Butyrate Metabolite chebi:17968 wikidata:Q55582441 chebi:17968;chebi:17968 inchikey:FERIUCNNQQJTOY-UHFFFAOYSA-M L-Kynurenine Metabolite cas:343-65-7 L-Kynurenine wikidata:Q32908783 chebi:28683;chebi:28683 inchikey:YGPSJZOEDVAXAB-UHFFFAOYSA-N Melatonin Metabolite hmdb:HMDB0001389 chebi:16796;chebi:16796 inchikey:DRLFMBDRBRZALE-UHFFFAOYSA-N 5-Hydroxykynurenine Metabolite cas:484-78-6 wikidata:Q2815992 chebi:1547;chebi:1547 inchikey:VCKPUUFAIGNJHC-UHFFFAOYSA-N Xanthurenic acid Metabolite hmdb:HMDB0000881 chebi:10072;chebi:10072 inchikey:FBZONXHGGPHHIY-UHFFFAOYSA-N Indole-3-acetamide Metabolite chebi:16031 AKA IAM wikidata:Q27097844 chebi:16031;chebi:16031 inchikey:ZOAMBXDOGPRZLP-UHFFFAOYSA-N N-Methylserotonin Metabolite hmdb:HMDB0004369 chebi:48294;chebi:48294 inchikey:ASUSBMNYRHGZIG-UHFFFAOYSA-N Tryptophol Metabolite chebi:17890 wikidata:Q5479351 chebi:17890;chebi:17890 inchikey:MBBOMCVGYCRMEA-UHFFFAOYSA-N Tryptamine Metabolite cas:61-54-1 wikidata:Q409439 chebi:16765;chebi:16765 inchikey:APJYDQYYACXCRM-UHFFFAOYSA-N 5-Hydroxy-N-formylkynurenine Metabolite hmdb:HMDB0004086 chebi:2065;chebi:2065 inchikey:LSTOUSIIVKMJBU-UHFFFAOYSA-N 4,6-Dihydroxyquinoline Metabolite hmdb:HMDB0004077 chebi:28799;chebi:28799 inchikey:XFALURCRIGINGT-UHFFFAOYSA-N indole-sulfonic acid Metabolite pubchem.compound:12904055 SCFAs Metabolite chebi:26666 Short-Chain-fatty-acids wikidata:Q2698455 chebi:26666;chebi:26666 L-Tryptophan Metabolite cas:73-22-3 wikidata:Q106345470;wikidata:Q181003 chebi:57912;chebi:16828;chebi:16828;chebi:57912 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N Kynurenic Acid Metabolite chebi:18344 wikidata:Q642217 chebi:18344;chebi:18344 inchikey:HCZHHEIFKROPDY-UHFFFAOYSA-N Acetoacetyl-CoA Metabolite kegg.compound:C00332 wikidata:Q2639429 chebi:15345;chebi:15345 inchikey:OJFDKHTZOUZBOS-CITAKDKDSA-N Indican Metabolite chebi:16700 wikidata:Q418392 chebi:16700;chebi:16700 inchikey:XVARCVCWNFACQC-RKQHYHRCSA-N N-Methyltryptamine Metabolite chebi:28136 wikidata:Q308875 chebi:28136;chebi:28136 inchikey:NCIKQJBVUNUXLW-UHFFFAOYSA-N Crotonoyl-CoA Metabolite kegg.compound:C00877 wikidata:Q303169 chebi:36926;chebi:15473;chebi:15473 inchikey:KFWWCMJSYSSPSK-PAXLJYGASA-N 5-Hydroxyindoleacetaldehyde Metabolite hmdb:HMDB0004073 AKA 5-HIAA chebi:50157;chebi:50157 inchikey:OBFAPCIUSYHFIE-UHFFFAOYSA-N 4-aminobenzoic acid Metabolite chebi:30753 wikidata:Q284959 chebi:30753;chebi:30753 inchikey:ALYNCZNDIQEVRV-UHFFFAOYSA-N Indolyl acryloyl glycine Metabolite chebi:145761 wikidata:Q15411025 chebi:145761;chebi:145761 inchikey:DUIFVCFSAWHIOD-AATRIKPKSA-N Tyramine Metabolite chebi:15760 wikidata:Q165930 chebi:15760;chebi:15760 inchikey:DZGWFCGJZKJUFP-UHFFFAOYSA-N 6-Hydroxymelatonin Metabolite cas:2208-41-5 wikidata:Q20707319 chebi:2198;chebi:2198 inchikey:OMYMRCXOJJZYKE-UHFFFAOYSA-N Indole-3-aldehyde Metabolite chebi:28238 AKA IAId wikidata:Q27103575 chebi:28238;chebi:28238 inchikey:OLNJUISKUQQNIM-UHFFFAOYSA-N Glutaryl-CoA Metabolite kegg.compound:C00527 wikidata:Q3066713 chebi:15524;chebi:15524 inchikey:SYKWLIJQEHRDNH-CKRMAKSASA-N cholate Metabolite chebi:29747 wikidata:Q27104085 chebi:29747;chebi:29747 inchikey:BHQCQFFYRZLCQQ-OELDTZBJSA-M N-Acetylserotonin Metabolite cas:1210-83-9 AKA N-Acetylserotonin, NAS wikidata:Q4847704 chebi:17697;chebi:17697 inchikey:MVAWJSIDNICKHF-UHFFFAOYSA-N picolinate Metabolite kegg.compound:C10164 wikidata:Q416682 chebi:28747;chebi:28747 inchikey:SIOXPEMLGUPBBT-UHFFFAOYSA-N IA Metabolite chebi:132244 AKA Indole acrylic acid wikidata:Q27225487 chebi:132244;chebi:132244 inchikey:PLVPPLCLBIEYEA-AATRIKPKSA-N IPA Metabolite chebi:43580 AKA Indole-3-propionic acid wikidata:Q21098993 chebi:43580;chebi:43580 inchikey:GOLXRNDWAUTYKT-UHFFFAOYSA-N Quinaldic Acid Metabolite chebi:18386 wikidata:Q17189267 chebi:18386;chebi:18386 inchikey:LOAUVZALPPNFOQ-UHFFFAOYSA-N Indole acetic glutamine Metabolite chebi:176458 chebi:176458 SCFAs Metabolite chebi:26666 Short-Chain-fatty-acids wikidata:Q2698455 chebi:26666;chebi:26666 IDO2 GeneProduct ncbigene:169355 ensembl:ENSG00000188676 ncbigene:169355 hgnc.symbol:IDO2 uniprot:A0A0N4SWI6;uniprot:Q6ZQW0 GCDH GeneProduct ncbigene:2639 predicted ensembl:ENSG00000105607 ncbigene:2639 hgnc.symbol:GCDH uniprot:K7ES74;uniprot:K7EQ99;uniprot:K7ER63;uniprot:K7EKT3;uniprot:K7ERX1;uniprot:Q92947;uniprot:K7ESA6;uniprot:A0A024R7F9;uniprot:K7EKH1 ALDH2 GeneProduct ncbigene:217 ensembl:ENSG00000111275 ncbigene:217 hgnc.symbol:ALDH2 uniprot:A0A384NPN7;uniprot:P05091;uniprot:S4R3S4;uniprot:F8VSB0 4.1.1.- GeneProduct eccode:4.1.1.- Unclear which specific protein acts in this reaction ASMT GeneProduct ncbigene:438 ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 IDO2 GeneProduct ensembl:ENSG00000188676 ensembl:ENSG00000188676 ncbigene:169355 hgnc.symbol:IDO2 uniprot:A0A0N4SWI6;uniprot:Q6ZQW0 1.5.1.- GeneProduct eccode:1.5.1.- Unclear which specific protein acts in this reaction. CYP1A1 GeneProduct ncbigene:1543 ensembl:ENSG00000140465 ncbigene:1543 hgnc.symbol:CYP1A1 uniprot:E7EMT5;uniprot:P04798;uniprot:A0N0X8;uniprot:A4F3V8 DLD GeneProduct ncbigene:1738 aka OADH ensembl:ENSG00000091140 ncbigene:1738 hgnc.symbol:DLD uniprot:F2Z2E3;uniprot:F8WDM5;uniprot:F8WDY5;uniprot:P09622;uniprot:E9PEX6;uniprot:A0A024R713 MAOA GeneProduct ncbigene:4128 ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 DDC GeneProduct ncbigene:1644 In Agus et al, this protein is called 'AAAD', aka 'aromatic amino acid decarboxylase', which is known in UniProt at DCC; AAAD is an unrelated protein and its addition to Figure 2 of this paper is questionable [PMID:29902437]. Fig. 1 [PMID:31825083] mentions AADC, in peripheral synthesis. ensembl:ENSG00000132437 ncbigene:1644 hgnc.symbol:DDC uniprot:H7BZF7;uniprot:A0A0S2Z3N4;uniprot:C9JMP0;uniprot:P20711;uniprot:F8WER1;uniprot:A0A087WU57;uniprot:A0A087WV24 CAT GeneProduct ncbigene:847 ensembl:ENSG00000121691 ncbigene:847 hgnc.symbol:CAT uniprot:A0A3B3ITJ0;uniprot:P04040;uniprot:A0A384P5Q0 STAT1 GeneProduct ensembl:ENSG00000115415 ensembl:ENSG00000115415 ncbigene:6772 hgnc.symbol:STAT1 uniprot:E9PH66;uniprot:A0A669KBK4;uniprot:E7EPD2;uniprot:J3KPM9;uniprot:Q67C41;uniprot:A0A669KB17;uniprot:A0A669KB56;uniprot:A0A669KB68;uniprot:A0A669KB52;uniprot:A0A669KB53;uniprot:A0A669KB75;uniprot:D2KFR9;uniprot:P42224;uniprot:A0A669KBA4;uniprot:E7ENM1;uniprot:A0A669KBI6 DDC GeneProduct ncbigene:1644 ensembl:ENSG00000132437 ncbigene:1644 hgnc.symbol:DDC uniprot:H7BZF7;uniprot:A0A0S2Z3N4;uniprot:C9JMP0;uniprot:P20711;uniprot:F8WER1;uniprot:A0A087WU57;uniprot:A0A087WV24 DDC GeneProduct ncbigene:1644 Known under two EC numbers: aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28; EC:4.1.1.105] ensembl:ENSG00000132437 ncbigene:1644 hgnc.symbol:DDC uniprot:H7BZF7;uniprot:A0A0S2Z3N4;uniprot:C9JMP0;uniprot:P20711;uniprot:F8WER1;uniprot:A0A087WU57;uniprot:A0A087WV24 MAOA GeneProduct ncbigene:4128 ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 ACAT1 GeneProduct ncbigene:38 ensembl:ENSG00000075239 ncbigene:38 hgnc.symbol:ACAT1 uniprot:E9PRQ6;uniprot:A0A5F9ZHD4;uniprot:A0A5F9ZHJ7;uniprot:H0YEL7;uniprot:A0A140VJX1;uniprot:A0A5F9ZHH9;uniprot:A0A5F9ZI66;uniprot:A0A5F9ZHL1;uniprot:A0A5F9ZHJ0;uniprot:A0A5F9ZHL7;uniprot:P24752 INDO2 GeneProduct ncbigene:3620 ensembl:ENSG00000131203 ncbigene:3620 hgnc.symbol:IDO1 uniprot:A0A348GSI3;uniprot:E5RIX2;uniprot:J3KN03;uniprot:P14902;uniprot:A0A140T9Z2;uniprot:E5RH36 AFMID GeneProduct ncbigene:125061 ensembl:ENSG00000183077 ncbigene:125061 hgnc.symbol:AFMID uniprot:Q63HM1;uniprot:W4VSQ7;uniprot:K7ELV9;uniprot:K7EQK5;uniprot:K7EMI4;uniprot:K7EMM5;uniprot:K7EPF8;uniprot:K7EIX3;uniprot:K7EK09 AANAT GeneProduct ncbigene:15 ensembl:ENSG00000129673 ncbigene:15 hgnc.symbol:AANAT uniprot:Q16613;uniprot:F1T0I5;uniprot:K7ERF6;uniprot:K7ESH7 ALDH8A1 GeneProduct ncbigene:64577 ensembl:ENSG00000118514 ncbigene:64577 hgnc.symbol:ALDH8A1 uniprot:Q9H2A2;uniprot:E9PKV1;uniprot:H0YF40 AOX1 GeneProduct ncbigene:316 ensembl:ENSG00000138356 ncbigene:316 hgnc.symbol:AOX1 uniprot:C9J244;uniprot:Q06278;uniprot:H7BXF7;uniprot:H7C3Q1 AADAT GeneProduct ncbigene:56267 ensembl:ENSG00000137944 ncbigene:56267 hgnc.symbol:KYAT3 uniprot:Q6YP21;uniprot:B4DW13;uniprot:A0A0A0MRN7 ACMSD GeneProduct ncbigene:130013 ensembl:ENSG00000153086 ncbigene:130013 hgnc.symbol:ACMSD uniprot:Q8TDX5;uniprot:A0A0S2Z681 KMO GeneProduct ncbigene:8564 liver PW ensembl:ENSG00000117009 ncbigene:8564 hgnc.symbol:KMO uniprot:H0Y320;uniprot:O15229 KYNU GeneProduct ncbigene:8942 AKA kynureninase ensembl:ENSG00000115919 ncbigene:8942 hgnc.symbol:KYNU uniprot:A0A087WYM2;uniprot:F8WEP1;uniprot:B8ZZA3;uniprot:A0A087WYQ7;uniprot:A0A087X297;uniprot:Q16719 INMT GeneProduct ncbigene:11185 ensembl:ENSG00000241644 ncbigene:11185 hgnc.symbol:INMT uniprot:O95050 HAAO GeneProduct ncbigene:23498 AKA 3-hydroxyanthraniate 3,4-dioxygenase ensembl:ENSG00000162882 ncbigene:23498 hgnc.symbol:HAAO uniprot:C9IY88;uniprot:P46952 AOC1 GeneProduct ncbigene:26 aka ABP1 ensembl:ENSG00000002726 ncbigene:26 hgnc.symbol:AOC1 uniprot:C9J0G8;uniprot:P19801;uniprot:C9J2J4 MAOA GeneProduct ncbigene:4128 AKA Monoamine Ozydase (MAO) ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 IDO1 GeneProduct ensembl:ENSG00000131203 ensembl:ENSG00000131203 ncbigene:3620 hgnc.symbol:IDO1 uniprot:A0A348GSI3;uniprot:E5RIX2;uniprot:J3KN03;uniprot:P14902;uniprot:A0A140T9Z2;uniprot:E5RH36 KYNU GeneProduct ncbigene:8942 ensembl:ENSG00000115919 ncbigene:8942 hgnc.symbol:KYNU uniprot:A0A087WYM2;uniprot:F8WEP1;uniprot:B8ZZA3;uniprot:A0A087WYQ7;uniprot:A0A087X297;uniprot:Q16719 INMT GeneProduct ncbigene:11185 ensembl:ENSG00000241644 ncbigene:11185 hgnc.symbol:INMT uniprot:O95050 ECHS1 GeneProduct ncbigene:1892 ensembl:ENSG00000127884 ncbigene:1892 hgnc.symbol:ECHS1 uniprot:P30084 TDO2 GeneProduct ncbigene:6999 liver PW ensembl:ENSG00000151790 ncbigene:6999 hgnc.symbol:TDO2 uniprot:D6RA50;uniprot:D6RB68;uniprot:P48775 TPH2 GeneProduct ncbigene:121278 produced in the brain; central synthesis ensembl:ENSG00000139287 ncbigene:121278 hgnc.symbol:TPH2 uniprot:Q8IWU9 ASMT GeneProduct ncbigene:438 ensembl:ENSG00000196433 ncbigene:438 hgnc.symbol:ASMT uniprot:X5D784;uniprot:I7HFW6;uniprot:X5D2A4;uniprot:A0A024RBT9;uniprot:P46597 IDO2 GeneProduct ncbigene:169355 brain, liver and gut PW ensembl:ENSG00000188676 ncbigene:169355 hgnc.symbol:IDO2 uniprot:A0A0N4SWI6;uniprot:Q6ZQW0 AFMID GeneProduct ncbigene:125061 ensembl:ENSG00000183077 ncbigene:125061 hgnc.symbol:AFMID uniprot:Q63HM1;uniprot:W4VSQ7;uniprot:K7ELV9;uniprot:K7EQK5;uniprot:K7EMI4;uniprot:K7EMM5;uniprot:K7EPF8;uniprot:K7EIX3;uniprot:K7EK09 KYNU GeneProduct ncbigene:8942 ensembl:ENSG00000115919 ncbigene:8942 hgnc.symbol:KYNU uniprot:A0A087WYM2;uniprot:F8WEP1;uniprot:B8ZZA3;uniprot:A0A087WYQ7;uniprot:A0A087X297;uniprot:Q16719 IDO2 GeneProduct ncbigene:169355 ensembl:ENSG00000188676 ncbigene:169355 hgnc.symbol:IDO2 uniprot:A0A0N4SWI6;uniprot:Q6ZQW0 ALDH2 Protein uniprot:P05091 ensembl:ENSG00000111275 ncbigene:217 hgnc.symbol:ALDH2 uniprot:A0A384NPN7;uniprot:P05091;uniprot:S4R3S4;uniprot:F8VSB0 IDO1 Protein uniprot:P14902 AKA indoleamine 2,3-dioxygenase, in both immune and epithelial cells [PMID: 22688187] ensembl:ENSG00000131203 ncbigene:3620 hgnc.symbol:IDO1 uniprot:A0A348GSI3;uniprot:E5RIX2;uniprot:J3KN03;uniprot:P14902;uniprot:A0A140T9Z2;uniprot:E5RH36 TpH1 Protein uniprot:P17752 AKA Trp hydroxylase 1, produced in intestinal epithelial cells; peripheral synthesis ensembl:ENSG00000129167 ncbigene:7166 hgnc.symbol:TPH1 uniprot:E9PR49;uniprot:E7EMX4;uniprot:P17752 HDAC Protein interpro:IPR000286 Family of proteins MAOA Protein ncbigene:4128 ensembl:ENSG00000189221 ncbigene:4128 hgnc.symbol:MAOA uniprot:Q53YE7;uniprot:P21397 AHR Protein hgnc.symbol:AHR ensembl:ENSG00000106546 ncbigene:196 hgnc.symbol:AHR uniprot:A0A2R8Y7G1;uniprot:P35869;uniprot:A0A024R9Z8 IL4I1 Protein uniprot:Q96RQ9 ensembl:ENSG00000104951 ncbigene:259307 hgnc.symbol:IL4I1 uniprot:Q96RQ9;uniprot:M0R1L1;uniprot:M0QXY7;uniprot:M0QYH9;uniprot:M0QYW8;uniprot:M0R2S9 fldH Protein uniprot:G9EZR6 AKA phenyllactate dehydrogenase or indolelactic acid dehydrogenase (ILDH); species: Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) ArAT Protein eccode:2.6.1.57 AKA Aromatic amino acid aminotransferase, group of proteins KYAT1 Protein uniprot:Q16773 KAT I/glutamine transaminase K/cysteine conjugate beta-lyase 1 ensembl:ENSG00000171097 ncbigene:883 hgnc.symbol:KYAT1 uniprot:A8K563;uniprot:Q16773;uniprot:Q5T277;uniprot:Q5T276;uniprot:B7Z4W5;uniprot:Q5T278 TMO Protein uniprot:P48775 AKA Tryptophan 2,3-dioxygenase; abbreviation TMO is not know in UniProt (TDO2 is the gene name). ensembl:ENSG00000151790 ncbigene:6999 hgnc.symbol:TDO2 uniprot:D6RA50;uniprot:D6RB68;uniprot:P48775 TNA Protein uniprot:P31015 AKA Tryptophanase (2); Species: Symbiobacterium thermophilum (strain T / IAM 14863) HADH Protein uniprot:Q16836 ensembl:ENSG00000138796 ncbigene:3033 hgnc.symbol:HADH uniprot:A0A1W2PP40;uniprot:A0A0D9SFP2;uniprot:Q16836;uniprot:A0A0A0MSE2;uniprot:E9PF18;uniprot:A0A1W2PQC2;uniprot:A0A1W2PRM6;uniprot:J3KR89;uniprot:A0A140VK76;uniprot:A0A1W2PQV5;uniprot:A0A1W2PRT2;uniprot:A0A1W2PNM1;uniprot:A0A1W2PQ78;uniprot:A0A1W2PQ55 porB Protein uniprot:Q9ZKA3 AKA pyruvate : ferrodoxin oxidoreductase B; Species: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) acdA Protein uniprot:P45867 AKA acyl-CoA dehydrogenase; Species: Bacillus subtilis (strain 168) fldH Protein uniprot:J7SHB8 AKA phenyllactate dehydrogenase or indolelactic acid dehydrogenase (ILDH); species: Clostridium sporogenes (strain ATCC 15579) fldB Protein uniprot:Q93AL9 AKA phenyllactate dehydratase; fldBC is know as two entries in UniProt (fldB and fldC); Species: Clostridium sporogenes fldC Protein uniprot:Q93AL8 AKA phenyllactate dehydratase; fldBC is know as two entries in UniProt (fldB and fldC); Species: Clostridium sporogenes acdA Protein uniprot:J7TF92 AKA acyl-CoA dehydrogenase; Species: Clostridium sporogenes (strain ATCC 15579) TNA Protein uniprot:P31014 AKA Tryptophanase (1); Species: Symbiobacterium thermophilum (strain T / IAM 14863) TNA Protein uniprot:Q9ZNA8 AKA Tryptophanase; Species: Proteus inconstans TNA Protein uniprot:O07674 AKA Tryptophanase; Species: Haemophilus influenzae KYAT2 Protein uniprot:Q8N5Z0 KAT II/aminoadipate aminotransferase ensembl:ENSG00000109576 ncbigene:51166 hgnc.symbol:AADAT uniprot:D6REB9;uniprot:Q8N5Z0;uniprot:D6RC56;uniprot:D6RFY7;uniprot:Q4W5N8 KYAT3 Protein uniprot:Q6YP21 KAT III/cysteine conjugate beta-lyase 2 ensembl:ENSG00000137944 ncbigene:56267 hgnc.symbol:KYAT3 uniprot:Q6YP21;uniprot:B4DW13;uniprot:A0A0A0MRN7 KYAT4 Protein uniprot:P00505 KAT IV/glutamic-oxaloacetic transaminase 2/mitochondrial aspartate aminotransferase ensembl:ENSG00000125166 ncbigene:2806 hgnc.symbol:GOT2 uniprot:H3BRE7;uniprot:P00505 AHR Protein hgnc.symbol:AHR ensembl:ENSG00000106546 ncbigene:196 hgnc.symbol:AHR uniprot:A0A2R8Y7G1;uniprot:P35869;uniprot:A0A024R9Z8 AHR Protein hgnc.symbol:AHR ensembl:ENSG00000106546 ncbigene:196 hgnc.symbol:AHR uniprot:A0A2R8Y7G1;uniprot:P35869;uniprot:A0A024R9Z8 AHR Protein hgnc.symbol:AHR ensembl:ENSG00000106546 ncbigene:196 hgnc.symbol:AHR uniprot:A0A2R8Y7G1;uniprot:P35869;uniprot:A0A024R9Z8 IDO1 Protein uniprot:P14902 AKA indoleamine 2,3-dioxygenase, in both immune and epithelial cells [PMID: 22688187] ensembl:ENSG00000131203 ncbigene:3620 hgnc.symbol:IDO1 uniprot:A0A348GSI3;uniprot:E5RIX2;uniprot:J3KN03;uniprot:P14902;uniprot:A0A140T9Z2;uniprot:E5RH36 IDO2 Protein uniprot:Q6ZQW0 brain, liver and gut PW ensembl:ENSG00000188676 ncbigene:169355 hgnc.symbol:IDO2 uniprot:A0A0N4SWI6;uniprot:Q6ZQW0 STAT1 Protein uniprot:P42224 ensembl:ENSG00000115415 ncbigene:6772 hgnc.symbol:STAT1 uniprot:E9PH66;uniprot:A0A669KBK4;uniprot:E7EPD2;uniprot:J3KPM9;uniprot:Q67C41;uniprot:A0A669KB17;uniprot:A0A669KB56;uniprot:A0A669KB68;uniprot:A0A669KB52;uniprot:A0A669KB53;uniprot:A0A669KB75;uniprot:D2KFR9;uniprot:P42224;uniprot:A0A669KBA4;uniprot:E7ENM1;uniprot:A0A669KBI6 STAT1 Protein uniprot:P42224 FN-gamma–dependent phosphorylation of STAT1 ensembl:ENSG00000115415 ncbigene:6772 hgnc.symbol:STAT1 uniprot:E9PH66;uniprot:A0A669KBK4;uniprot:E7EPD2;uniprot:J3KPM9;uniprot:Q67C41;uniprot:A0A669KB17;uniprot:A0A669KB56;uniprot:A0A669KB68;uniprot:A0A669KB52;uniprot:A0A669KB53;uniprot:A0A669KB75;uniprot:D2KFR9;uniprot:P42224;uniprot:A0A669KBA4;uniprot:E7ENM1;uniprot:A0A669KBI6